Results 41 to 50 of about 15,268 (219)

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome [PDF]

, 2019
Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology.
Barbera L. L., Ciccia F., Guggino G., Pizzo M. L., Rizzo C., Sireci G.   +5 more
core   +1 more source

Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes

Frontiers in Immunology, 2023
Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look, Daniel Burns, Ivo Tews, Ivo Tews, Ali Roghanian, Ali Roghanian, Salah Mansour, Salah Mansour   +7 more
doaj   +1 more source

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources

Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]

, 2017
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong, Hung, Jung-Tung, Yu, Alice L   +2 more
core   +2 more sources

Cytokine dependent and independent iNKT cell activation [PDF]

Cytokine, 2010
Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold.
Emma C, Reilly, Jack R, Wands, Laurent, Brossay   +2 more
openaire   +2 more sources

Reading the room: iNKT cells influence B cell responses

Molecular Immunology, 2021
Rapid immune responses regulated by invariant Natural Killer T (iNKT) cells bridge the gap between innate and adaptive responses to pathogens, while also providing key regulation to maintain immune homeostasis. iNKT immune protection and immune regulation are both mediated through interactions with innate and adaptive B cell populations that express ...
Elizabeth A. Leadbetter, Mikael C.I. Karlsson   +1 more
openaire   +3 more sources

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells [PDF]

, 2013
Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral ...
A Bendelac, A Bendelac, A Reschner, AK Savage, AM Fahrer, B Johnston, BM Sullivan, BN Weber, C Grégoire, C Kuylenstierna, C Paget, D Kovalovsky, DI Godfrey, DI Godfrey, DM Andrews, E Vivier, Gerald F Watts, H Sun, H Watarai, HD Marshall, J Shires, JE Gumperz, JL Matsuda, JL Matsuda, JL Matsuda, JM Coquet, Joonsoo Kang, K Inagaki-Ohara, K Miyazaki, L Gattinoni, L Gattinoni, LE Gordy, LL Lanier, M Brigl, M Brigl, M Brigl, M Maeda, M Salio, MA Cooper, Manfred Brigl, Michael B Brenner, MJ Townsend, MS Vincent, Nadia R Cohen, NC Fernandez, NR Cohen, NY Crowe, P Kastner, Patrick J Brennan, PD Thomas, PJ Brennan, RL O'Brien, S Honma, S Yu, T Kawamura, T Ota, T Walzer, T Willinger, Tal Shay, TSP Heng, V Cerundolo, W Huang da, X Yue, Y Makino   +63 more
core   +5 more sources

Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]

, 2017
Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine, Elewaut, Dirk, Froeyen, Mathy, Guillaume, Joren, Janssens, Jonas, Remesh, Soumya G, Risseeuw, Martijn, Van Calenbergh, Serge, Wang, Jing, Zajonc, Dirk M   +9 more
core   +1 more source

Regulated expression of miR-155 is required for iNKT cell development

Frontiers in Immunology, 2015
Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi, Paola ePittoni, Esmerina eTili, Esmerina eTili, Alice eRigoni, Stefan eCostinean, Carlo Maria Croce, MARIO Paolo COLOMBO   +7 more
doaj   +1 more source

Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]

PLoS ONE, 2013
Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu, Shudan Shen, Jialong Yang, Zhenwei Xia, Xiao-Ping Zhong   +4 more
doaj   +1 more source