Results 41 to 50 of about 10,168 (211)
The response of CD1d-restricted invariant NKT cells to microbial pathogens and their products
Frontiers in Immunology, 2015 Invariant natural killer T (iNKT) cells become activated during a wide variety of infections. This includes organisms lacking cognate CD1d-binding glycolipid antigens recognized by the semi-invariant T cell receptor of iNKT cells. Additional studies have
Luc eVan Kaer, Vrajesh eParekh, Lan eWu
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Targeting iNKT cells for the treatment of sickle cell disease [PDF]
Clinical Immunology, 2011 Sickle cell disease (SCD) causes widely disseminated vaso-occlusive episodes. Building on evidence implicating invariant NKT (iNKT) cells in the pathogenesis of ischemia/reperfusion injury, recent studies demonstrate that blockade of iNKT cell activation in mice with SCD reduces pulmonary inflammation and injury.
Joshua J, Field +2 more
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A circulating subset of iNKT cells mediates antitumor and antiviral immunity [PDF]
, 2022 新規の循環型iNKT細胞を発見 --抗腫瘍・抗ウイルス感染効果の高い免疫細胞療法の開発への貢献に期待--. 京都大学プレスリリース. 2022-10-24.Invariant natural killer T (iNKT) cells are a group of innate-like T lymphocytes that recognize lipid antigens.
Minato, Nagahiro +37 more
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Generation of Mouse iNKT Cell Lines
BIO-PROTOCOL, 2013 Natural killer T (NKT) cells bridge the innate and adaptive arms of the immune system, and manipulating their effector functions can have therapeutic significances in the treatment of autoimmunity, transplant biology, infectious disease and cancer. This important lymphocyte subset regulates the immune system through their potent cytokine production ...
Xiangming Li +3 more
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Redirecting iNKT Cell Antitumor Immunity with α-GalCer/CD1d-scFv Fusion Proteins
, 2021 Invariant natural killer T (iNKT) cells display important properties that could bridge the innate and adaptive immunity, and they have been shown to play key roles in cancer immunotherapy.
Lianjun Zhang +3 more
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Regulated expression of miR-155 is required for iNKT cell development
Frontiers in Immunology, 2015 Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi +7 more
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Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes
Frontiers in Immunology, 2023 Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look +7 more
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Immunoregulation by iNKT Cells
YAKUGAKU ZASSHI, 2009 NKT cells are defined as cells co-expressing of the natural killer receptors such as NK1.1 or NKR-P1A (CD161) and a T cell receptor (TCR). Although NK1.1(+) TCR(+) lymphocytes are heterogeneous, we focus on two distinct T cell subsets express invariant T cell receptor alpha chains, Valpha14-Jalpha18(Valpha14i) and Valpha19-Jalpha33(Valpha19i ...
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Cytokine dependent and independent iNKT cell activation [PDF]
Cytokine, 2010 Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold.
Emma C, Reilly +2 more
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Frontiers in Immunology, 2022 Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by heterogeneous inflammatory endotypes of unknown etiology. Invariant natural killer T (iNKT) cells are multifunctional innate T cells that exhibit Th1-, Th2-, and Th17-like ...
Xiaoyan Ye +14 more
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