Results 21 to 30 of about 8,218 (178)
eLife, 2022 Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane +9 more
doaj +1 more source
Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells
Cell Reports, 2014 Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Invariant natural killer T (iNKT) cells are innate-like T lymphocytes cells that recognize glycolipid antigens associated with CD1d, non-classical antigen presenting proteins.
Abel Trujillo-Ocampo +8 more
doaj +1 more source
Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy
Frontiers in Immunology, 2018 iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens presented by CD1d molecules.
Benjamin J. Wolf +5 more
doaj +1 more source
Stem Cell Research & Therapy, 2022 Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li +11 more
doaj +1 more source
eLife, 2023 Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While many studies show that the development and functions of innate and adaptive immune cells depend on their metabolic state ...
Jaemoon Koh +10 more
doaj +1 more source
Frontiers in Immunology, 2019 The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao +8 more
doaj +1 more source
The iNKT Cell–Macrophage Axis in Homeostasis and Disease [PDF]
International Journal of Molecular Sciences, 2022 Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit preponderant immunomodulatory properties. The ultimate protective or deleterious functions displayed by iNKT cells in tissues are known to be partially shaped by the interactions they establish with other immune cells.
Mariana S. Cruz +3 more
openaire +2 more sources
The response of CD1d-restricted invariant NKT cells to microbial pathogens and their products
Frontiers in Immunology, 2015 Invariant natural killer T (iNKT) cells become activated during a wide variety of infections. This includes organisms lacking cognate CD1d-binding glycolipid antigens recognized by the semi-invariant T cell receptor of iNKT cells. Additional studies have
Luc eVan Kaer, Vrajesh eParekh, Lan eWu
doaj +1 more source
Regulated expression of miR-155 is required for iNKT cell development
Frontiers in Immunology, 2015 Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi +7 more
doaj +1 more source