Results 21 to 30 of about 15,268 (219)

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

eLife, 2022
Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch   +9 more
doaj   +1 more source

Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]

PLoS ONE, 2012
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li, Patricia Polacino, Raquel Garcia-Navarro, Shiu-Lok Hu, Moriya Tsuji   +4 more
doaj   +1 more source

Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells

Cell Reports, 2014
Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan, William Pooi-Kat Chong, Sze-Wai Ng, Nurhidayah Basri, Shengli Xu, Kong-Peng Lam   +5 more
doaj   +1 more source

IL-7 During Antigenic Stimulation Using Allogeneic Dendritic Cells Promotes Expansion of CD45RA-CD62L+CD4+ Invariant NKT Cells With Th-2 Biased Cytokine Production Profile

Frontiers in Immunology, 2020
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes cells that recognize glycolipid antigens associated with CD1d, non-classical antigen presenting proteins.
Abel Trujillo-Ocampo, Hyun-Woo Cho, Michael Clowers, Sumedha Pareek, Wilfredo Ruiz-Vazquez, Sung-Eun Lee, Sung-Eun Lee, Jin S. Im, Jin S. Im   +8 more
doaj   +1 more source

Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways

Frontiers in Immunology, 2023
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear.
Shiyu Bai, Shiyu Bai, Qielan Wu, Qielan Wu, Shasha Zhu, Yuwei Zhang, Yuwei Zhang, Xuran Chen, Xuran Chen, Miya Su, Miya Su, Jun Pan, Jun Pan, Shuhang Li, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Di Xie, Chenxi Tian, Chenxi Tian, Dan Zhao, Xiang Li, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Zhigang Tian, Zhigang Tian, Rongbin Zhou, Rongbin Zhou, Rongbin Zhou, Huimin Zhang, Huimin Zhang, Li Bai, Li Bai, Li Bai, Li Bai, Li Bai   +44 more
doaj   +1 more source

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
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Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy

Frontiers in Immunology, 2018
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens presented by CD1d molecules.
Benjamin J. Wolf, Jiyoung Elizabeth Choi, Jiyoung Elizabeth Choi, Mark A. Exley, Mark A. Exley, Mark A. Exley   +5 more
doaj   +1 more source

An optimized method for isolating and expanding invariant natural killer T cells from mouse spleen [PDF]

, 2015
The ability to rapidly secrete cytokines upon stimulation is a functional characteristic of the invariant natural killer T (iNKT) cell lineage. iNKT cells are therefore characterized as an innate T cell population capable of activating and steering ...
Drennan, Michael, Elewaut, Dirk, Govindarajan, Srinath   +2 more
core   +1 more source

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Stem Cell Research & Therapy, 2022
Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang   +11 more
doaj   +1 more source

Invariant natural killer T cells minimally influence gut microbiota composition in mice

Gut Microbes, 2022
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey   +10 more
doaj   +1 more source