Results 21 to 30 of about 10,168 (211)
iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
openaire +4 more sources
PLoS ONE, 2021 CD1d-restricted invariant natural killer T cells (iNKT cells) may play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Interleukin (IL)-15 is a pro-inflammatory cytokine which is over-expressed in SLE patients. In the present
Chien-Ya Hsu +6 more
doaj +1 more source
Recent advances in iNKT cell development [PDF]
F1000Research, 2020 Recent studies suggest that murine invariant natural killer T (iNKT) cell development culminates in three terminally differentiated iNKT cell subsets denoted as NKT1, 2, and 17 cells. Although these studies corroborate the significance of the subset division model, less is known about the factors driving subset commitment in iNKT cell progenitors.
Kristin Hogquist, Hristo Georgiev
openaire +2 more sources
Cell Discovery, 2023 Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus.
Jie Wang +12 more
doaj +1 more source
Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways
Frontiers in Immunology, 2023 Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear.
Shiyu Bai +44 more
doaj +1 more source
Ex Vivo Expansion of Th2-Polarizing Immunotherapeutic iNKT Cells from Human Peripheral Blood
, 2021 iNKT cells, classified as innate lymphocytes with invariant TCRs, have been highlighted as a putative, “off-the-shelf” cellular immunotherapeutic strategy for the treatment of malignant and nonmalignant diseases.
Kelly J. Andrews +5 more
core +1 more source
Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1 [PDF]
, 2023 Simple Summary The unique properties of invariant natural killer T (iNKT) cells make them an attractive candidate for cancer-adoptive immunotherapy. However, despite their potential, clinical studies have not consistently shown successful outcomes.
Lombardi G. +3 more
core +2 more sources
Frontiers in Immunology, 2020 Invariant natural killer T (iNKT) cells are innate-like T lymphocytes cells that recognize glycolipid antigens associated with CD1d, non-classical antigen presenting proteins.
Abel Trujillo-Ocampo +8 more
doaj +1 more source
Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-γ production in mice. [PDF]
PLoS ONE, 2012 During interaction with APCs, invariant (i) NKT cells are thought to be indirectly activated by TLR4-dependently activated APCs. However, whether TLR4 directly activates iNKT cells is unknown.
Ji Hyung Kim +4 more
doaj +1 more source
eLife, 2022 Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane +9 more
doaj +1 more source