Results 11 to 20 of about 8,218 (178)
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
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Generation of Human iNKT Cell Lines
Bio-Protocol, 2013 Natural killer T (NKT) cells comprise an important immunoregulatory T cell subset and express cell surface proteins characteristic of both natural killer cells and T cells.
Xiangming Li +3 more
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CD8+ T-cell immunity orchestrated by iNKT cells. [PDF]
Front Immunol, 2022 CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long-term prevention of their recurrence in hematologic malignancies.
Qin Y, Bao X, Zheng M.
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The transcriptional programs of iNKT cells [PDF]
Seminars in Immunology, 2015 Invariant natural killer T (iNKT) cells are innate T cells that express a semi-invariant T cell receptor (TCR) and recognize lipid antigens presented by CD1d molecules. As part of innate immunity, iNKT cells rapidly produce large amounts of cytokines after activation and regulate the function of innate and adaptive immune cells in antimicrobial ...
Edy Y, Kim +4 more
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iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
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Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]
PLoS ONE, 2012 In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li +4 more
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Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways
Frontiers in Immunology, 2023 Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear.
Shiyu Bai +44 more
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Recent advances in iNKT cell development [PDF]
F1000Research, 2020 Recent studies suggest that murine invariant natural killer T (iNKT) cell development culminates in three terminally differentiated iNKT cell subsets denoted as NKT1, 2, and 17 cells. Although these studies corroborate the significance of the subset division model, less is known about the factors driving subset commitment in iNKT cell progenitors.
Kristin Hogquist, Hristo Georgiev
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Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-γ production in mice. [PDF]
PLoS ONE, 2012 During interaction with APCs, invariant (i) NKT cells are thought to be indirectly activated by TLR4-dependently activated APCs. However, whether TLR4 directly activates iNKT cells is unknown.
Ji Hyung Kim +4 more
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The Role of Autophagy in iNKT Cell Development [PDF]
Frontiers in Immunology, 2018 CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses.
Guan Yang, John P. Driver, Luc Van Kaer
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