Results 11 to 20 of about 10,168 (211)
Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy [PDF]
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
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Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells
Cell Reports, 2014 Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan +5 more
doaj +2 more sources
, 2014 Natural killer T cells (NKT) are T lymphocytes with a reactivity directed against glycolipid antigens presented by MHC-like CD1d molecules expressed by antigen presenting cells (APC). A large proportion of these cells (invariant NKT cells (iNKT)) possess strong immunomodulatory properties which impose a profound impact on the development and course of ...
S. Bondarenko
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Generation of Human iNKT Cell Lines
Bio-Protocol, 2013 Natural killer T (NKT) cells comprise an important immunoregulatory T cell subset and express cell surface proteins characteristic of both natural killer cells and T cells.
Xiangming Li +3 more
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Cell Discovery, 2022 Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang +9 more
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Human iNKT Cells Modulate Macrophage Survival and Phenotype. [PDF]
Biomedicines, 2022 CD1d-restricted invariant Natural Killer T (iNKT) cells are unconventional innate-like T cells whose functions highly depend on the interactions they establish with other immune cells.
Loureiro JP +4 more
europepmc +2 more sources
CD8+ T-cell immunity orchestrated by iNKT cells. [PDF]
Front Immunol, 2022 CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long-term prevention of their recurrence in hematologic malignancies.
Qin Y, Bao X, Zheng M.
europepmc +4 more sources
Innate iNKT cells: from biological insight to clinical impact. [PDF]
Front ImmunolOver the past 30 years, work of immunologists worldwide has phenotypically and functionally defined “Natural Killer T cells” (NKT) and their subsets, including “invariant Natural Killer T cells” (iNKT). NKT cells make up a substantial fraction of T cells
Rotolo A, Mason NJ, Exley MA.
europepmc +3 more sources
CAR-iNKT cells: redefining the frontiers of cellular immunotherapy. [PDF]
Front ImmunolDespite significant advances in cancer therapies, many malignancies remain resistant to current treatments due to complex immunosuppressive mechanisms, limited neoantigen expression, and dynamic tumor adaptations, underscoring the need for innovative ...
Niedzielska M +10 more
europepmc +2 more sources
The transcriptional programs of iNKT cells [PDF]
Seminars in Immunology, 2015 Invariant natural killer T (iNKT) cells are innate T cells that express a semi-invariant T cell receptor (TCR) and recognize lipid antigens presented by CD1d molecules. As part of innate immunity, iNKT cells rapidly produce large amounts of cytokines after activation and regulate the function of innate and adaptive immune cells in antimicrobial ...
Edy Y, Kim +4 more
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