Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes [PDF]
Frontiers in Immunology, 2023 Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look +7 more
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Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment [PDF]
Cell Discovery, 2023 Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus.
Jie Wang +12 more
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Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy [PDF]
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
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Recent advances in iNKT cell development [version 1; peer review: 3 approved] [PDF]
F1000Research, 2020 Recent studies suggest that murine invariant natural killer T (iNKT) cell development culminates in three terminally differentiated iNKT cell subsets denoted as NKT1, 2, and 17 cells.
Kristin Hogquist, Hristo Georgiev
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Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy [PDF]
Inflammation and Regeneration, 2023 Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d.
Takahiro Aoki +2 more
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RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development [PDF]
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
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Traversing the bench to bedside journey for iNKT cell therapies [PDF]
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are immune cells that harness properties of both the innate and adaptive immune system and exert multiple functions critical for the control of various diseases.
Julie O’Neal +6 more
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ScRNA-Seq Analyses Define the Role of GATA3 in iNKT Cell Effector Lineage Differentiation [PDF]
CellsWhile the transcription factor GATA-3 is well-established for its crucial role in T cell development, its specific influence on invariant natural killer T (iNKT) cells remains relatively unexplored.
Tzong-Shyuan Tai +6 more
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Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury [PDF]
Frontiers in ImmunologyPolycomb repressive complex 2 (PRC2) is an evolutionarily conserved epigenetic modifier responsible for tri-methylation of lysine 27 on histone H3 (H3K27me3).
Yun Guo +9 more
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Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion [PDF]
Gut MicrobesThe interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells.
Angélica Díaz-Basabe +16 more
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