Results 1 to 10 of about 8,801 (173)
Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes [PDF]
Frontiers in Immunology, 2023 Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look +7 more
doaj +4 more sources
An in silico approach for modelling T-helper polarizing iNKT cell agonists. [PDF]
PLoS ONE, 2014 Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
Anton De Spiegeleer +9 more
doaj +10 more sources
CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells [PDF]
, 2018 Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear.
Bosma, A +6 more
core +4 more sources
α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding [PDF]
Frontiers in Chemistry, 2019 Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Alan Chuan-Ying Lai +7 more
doaj +3 more sources
Regulated expression of miR-155 is required for iNKT cell development
Frontiers in Immunology, 2015 Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi +7 more
doaj +3 more sources
Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells [PDF]
, 2017 Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Aya Castañeda, Maria del Rosario +6 more
core +3 more sources
Frontiers in Immunology, 2019 The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao +8 more
doaj +3 more sources
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to ...
Mariko Takami +3 more
doaj +3 more sources
The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation
Cell Reports, 2017 The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the ...
Yajun Wang +13 more
doaj +3 more sources
Gut MicrobesThe interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells.
Angélica Díaz-Basabe +16 more
doaj +3 more sources