Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy [PDF]
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
doaj +6 more sources
Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes [PDF]
Frontiers in Immunology, 2023 Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look +7 more
doaj +7 more sources
Recent advances in iNKT cell development [version 1; peer review: 3 approved] [PDF]
F1000Research, 2020 Recent studies suggest that murine invariant natural killer T (iNKT) cell development culminates in three terminally differentiated iNKT cell subsets denoted as NKT1, 2, and 17 cells.
Kristin Hogquist, Hristo Georgiev
doaj +5 more sources
Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy [PDF]
Inflammation and Regeneration, 2023 Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d.
Takahiro Aoki +2 more
doaj +3 more sources
Regulated expression of miR-155 is required for iNKT cell development
Frontiers in Immunology, 2015 Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi +7 more
doaj +4 more sources
The iNKT Cell-Macrophage Axis in Homeostasis and Disease. [PDF]
Int J Mol Sci, 2022 Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit preponderant immunomodulatory properties. The ultimate protective or deleterious functions displayed by iNKT cells in tissues are known to be partially shaped by the interactions they establish with other immune cells.
Cruz MS +3 more
europepmc +5 more sources
Porphyromonas gingivalis fuels colorectal cancer through CHI3L1-mediated iNKT cell-driven immune evasion [PDF]
Gut MicrobesThe interaction between the gut microbiota and invariant Natural Killer T (iNKT) cells plays a pivotal role in colorectal cancer (CRC). The pathobiont Fusobacterium nucleatum influences the anti-tumor functions of CRC-infiltrating iNKT cells.
Angélica Díaz-Basabe +16 more
doaj +4 more sources
Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment [PDF]
Cell Discovery, 2023 Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus.
Jie Wang +12 more
doaj +2 more sources
The RNA- and DNA-Binding Protein Y-Box Binding Protein 1 (YB-1) Regulates iNKT Cell Development. [PDF]
Eur J ImmunolYB‐1 is essential for invariant NKT cell development, integrating TCR, co‐stimulatory, and IL‐15 signaling to control maturation, subset differentiation, and survival. Its loss at the double‐positive thymocyte stage causes ∼80% iNKT cell depletion, maturation arrest, impaired cytokine production, and increased apoptosis.
Schulze S +7 more
europepmc +2 more sources
RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development [PDF]
Frontiers in Immunology, 2023 Receptor Interacting Protein Kinase 1 (RIPK1) and caspase-8 (Casp8) jointly orchestrate apoptosis, a key mechanism for eliminating developing T cells which have autoreactive or improperly arranged T cell receptors.
Thomas Hägglöf +6 more
doaj +2 more sources