Results 11 to 20 of about 8,083 (126)

The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation

Cell Reports, 2017
The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the ...
Yajun Wang, Chawon Yun, Beixue Gao, Yuanming Xu, Yana Zhang, Yiming Wang, Qingfei Kong, Fang Zhao, Chyung-Ru Wang, Sharon Y.R. Dent, Jian Wang, Xiangping Xu, Hua-Bin Li, Deyu Fang   +13 more
doaj   +3 more sources

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Cell Discovery, 2022
Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi   +9 more
doaj   +1 more source

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Stem Cell Research & Therapy, 2022
Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang   +11 more
doaj   +1 more source

Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Frontiers in Immunology, 2021
Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance ...
Ching-Lien Wu, Ching-Lien Wu, Ching-Lien Wu, Julien Caumartin, Giada Amodio, François Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult, Joel LeMaoult   +10 more
doaj   +1 more source

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Scientific Reports, 2021
Invariant Natural Killer T (iNKT) cells respond to the ligation of lipid antigen-CD1d complexes via their T-cell receptor and are implicated in various immunometabolic diseases.
Francesca A. Ververs, Suzanne E. Engelen, Roos Nuboer, Bas Vastert, Cornelis K. van der Ent, Belinda van’t Land, Johan Garssen, Claudia Monaco, Marianne Boes, Henk S. Schipper   +9 more
doaj   +1 more source

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. [PDF]

Cell Metab, 2020
LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.   +5 more
europepmc   +2 more sources

Regulated expression of miR-155 is required for iNKT cell development

Frontiers in Immunology, 2015
Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi, Paola ePittoni, Esmerina eTili, Esmerina eTili, Alice eRigoni, Stefan eCostinean, Carlo Maria Croce, MARIO Paolo COLOMBO   +7 more
doaj   +1 more source

iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. [PDF]

PLoS Pathogens, 2014
Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT cells suppress intracellular Mycobacterium tuberculosis (Mtb) replication.
Alissa C Rothchild, Pushpa Jayaraman, Cláudio Nunes-Alves, Samuel M Behar   +3 more
doaj   +1 more source

An in silico approach for modelling T-helper polarizing iNKT cell agonists. [PDF]

PLoS ONE, 2014
Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
Anton De Spiegeleer, Evelien Wynendaele, Matthias Vandekerckhove, Sofie Stalmans, Maxime Boucart, Nele Van Den Noortgate, Koen Venken, Serge Van Calenbergh, Sandrine Aspeslagh, Dirk Elewaut   +9 more
doaj   +1 more source