Results 11 to 20 of about 9,712 (187)
Traversing the bench to bedside journey for iNKT cell therapies [PDF]
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are immune cells that harness properties of both the innate and adaptive immune system and exert multiple functions critical for the control of various diseases.
Julie O’Neal +6 more
doaj +5 more sources
The Role of Autophagy in iNKT Cell Development. [PDF]
Front Immunol, 2018 CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses.
Yang G, Driver JP, Van Kaer L.
europepmc +6 more sources
The Lysine Acetyltransferase GCN5 Is Required for iNKT Cell Development through EGR2 Acetylation
Cell Reports, 2017 The development of CD1d-restricted invariant natural killer T (iNKT) cells, a population that is critical for both innate and adaptive immunity, is regulated by multiple transcription factors, but the molecular mechanisms underlying how the ...
Yajun Wang +13 more
doaj +4 more sources
iNKT and MAIT Cell Alterations in Diabetes [PDF]
Frontiers in Immunology, 2015 Type 1 diabetes (T1D) and type 2 diabetes (T2D) are multifactorial diseases with different etiologies in which chronic inflammation takes place. Defects in invariant natural killer T (iNKT) cell populations have been reported in both T1D and T2D patients, mouse models and our recent study revealed mucosal-associated invariant T (MAIT) cell defects in ...
Magalhaes, Isabelle +2 more
openaire +6 more sources
iNKT cell production of GM-CSF controls Mycobacterium tuberculosis. [PDF]
PLoS Pathogens, 2014 Invariant natural killer T (iNKT) cells are activated during infection, but how they limit microbial growth is unknown in most cases. We investigated how iNKT cells suppress intracellular Mycobacterium tuberculosis (Mtb) replication.
Alissa C Rothchild +3 more
doaj +3 more sources
Cell Discovery, 2022 Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang +9 more
doaj +2 more sources
Generation of Human iNKT Cell Lines
BIO-PROTOCOL, 2013 Natural killer T (NKT) cells comprise an important immunoregulatory T cell subset and express cell surface proteins characteristic of both natural killer cells and T cells. Invariant NKT (iNKT) cells are activated by lipid antigen presented in the context of CD1d molecules, in contrast to classic T cell subsets, which recognize peptide antigens ...
Xiangming Li +3 more
openaire +4 more sources
Generation of Mouse iNKT Cell Lines
BIO-PROTOCOL, 2013 Natural killer T (NKT) cells bridge the innate and adaptive arms of the immune system, and manipulating their effector functions can have therapeutic significances in the treatment of autoimmunity, transplant biology, infectious disease and cancer. This important lymphocyte subset regulates the immune system through their potent cytokine production ...
Xiangming Li +3 more
openaire +4 more sources
Frontiers in Immunology, 2019 The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao +8 more
doaj +3 more sources
Cell Reports, 2019 Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park +4 more
doaj +2 more sources