Results 31 to 40 of about 9,712 (187)

The transcriptional programs of iNKT cells [PDF]

Seminars in Immunology, 2015
Invariant natural killer T (iNKT) cells are innate T cells that express a semi-invariant T cell receptor (TCR) and recognize lipid antigens presented by CD1d molecules. As part of innate immunity, iNKT cells rapidly produce large amounts of cytokines after activation and regulate the function of innate and adaptive immune cells in antimicrobial ...
Edy Y, Kim, Lydia, Lynch, Patrick J, Brennan, Nadia R, Cohen, Michael B, Brenner   +4 more
openaire   +2 more sources

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

iNKT cell-neutrophil crosstalk promotes colorectal cancer pathogenesis [PDF]

, 2023
: iNKT cells account for a relevant fraction of effector T-cells in the intestine and are considered an attractive platform for cancer immunotherapy. Although iNKT cells are cytotoxic lymphocytes, their functional role in colorectal cancer (CRC) is still
Angélica Díaz-Basabe, Galassi, Barbara, Federica Facciotti, Nicassio, Francesco, Iachini, Luca, Giulia Protti, Facciotti, Federica, Ghidini, Michele, Mazzarella, Luca, Amoroso, Chiara, Perillo, Federica, Maurizio Vecchi, Díaz-Basabe, Angélica, Francesca Granucci, Elena Trombetta, Elisa Cassinotti, Francesco Nicassio, Vecchi, Maurizio, Trombetta, Elena, Ludovica Baldari, Rita Giuffrè, Maria, Michele Ghidini, Strati, Francesco, Gianluca Lopez, Luca Iachini, Porretti, Laura, Laura Porretti, Maria Rita Giuffrè, Giandomenica Iezzi, Messuti, Eleonora, Caprioli, Flavio, Eleonora Messuti, Baldari, Ludovica, Daniele Noviello, Federica Perillo, Lattanzi, Georgia, Georgia Lattanzi, Barbara Galassi, Alberto Baeri, Luca Mazzarella, Cassinotti, Elisa, Lopez, Gianluca, Protti, Giulia, Flavio Caprioli, Baeri, Alberto, Chiara Amoroso, Granucci, Francesca, Francesco Strati, Noviello, Daniele, Iezzi, Giandomenica   +49 more
core   +1 more source

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Stem Cell Research & Therapy, 2022
Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang   +11 more
doaj   +1 more source

Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Frontiers in Immunology, 2021
Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance ...
Ching-Lien Wu, Ching-Lien Wu, Ching-Lien Wu, Julien Caumartin, Giada Amodio, François Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult, Joel LeMaoult   +10 more
doaj   +1 more source

Immunometabolic factors in adolescent chronic disease are associated with Th1 skewing of invariant Natural Killer T cells

Scientific Reports, 2021
Invariant Natural Killer T (iNKT) cells respond to the ligation of lipid antigen-CD1d complexes via their T-cell receptor and are implicated in various immunometabolic diseases.
Francesca A. Ververs, Suzanne E. Engelen, Roos Nuboer, Bas Vastert, Cornelis K. van der Ent, Belinda van’t Land, Johan Garssen, Claudia Monaco, Marianne Boes, Henk S. Schipper   +9 more
doaj   +1 more source

CD8+ T-cell immunity orchestrated by iNKT cells

Frontiers in Immunology, 2023
CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long-term prevention of their recurrence in hematologic malignancies.
Yingyu Qin, Xueyang Bao, Mingzhu Zheng
openaire   +3 more sources

The autophagy machinery restrains iNKT cell activation through CD1D1 internalization [PDF]

, 2017
Invariant natural killer T (iNKT) cells are innate T cells with powerful immune regulatory functions that recognize glycolipid antigens presented by the CD1D protein.
Keller, Christian W, Jan D. Lünemann (3838321), Loi, M., Christian W. Keller, Gennaro De Libero (589502), Isaak Quast (3838312), Loi, Monica, Theiler, Romina, Ewert, Svenja, Münz, Christian, Loi, M, Monica Loi (3838315), Freigang, S., Monique Gannagé, Monique Gannagé (774489), Keller, CW, De Libero, Gennaro, Freigang, Stefan, Keller, C. W., Romina Theiler, Svenja Ewert (3838324), Stefan Freigang, Quast, I, Münz, C, Theiler, R., Christian W. Keller (3838318), Jan D. Lünemann, Svenja Ewert, Christian Münz, Gannagé, M, Munz, C., Monica Loi, Lunemann, J. D., Gannagé, Monique, Isaak Quast, De Libero, G., Romina Theiler (411647), Lünemann, Jan D, Christian Münz (86294), Stefan Freigang (413363), Quast, Isaak, Lünemann, JD, Ewert, S., Quast, I., Gannage, M., Gennaro De Libero   +45 more
core   +1 more source

Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway

Molecular Oncology, 2021
Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor immunity.
Angélica Díaz‐Basabe, Claudia Burrello, Georgia Lattanzi, Fiorenzo Botti, Alberto Carrara, Elisa Cassinotti, Flavio Caprioli, Federica Facciotti   +7 more
doaj   +1 more source

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

eLife, 2022
Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch   +9 more
doaj   +1 more source