Efficacy of Invariant Natural Killer T Cell Infusion Plus Transarterial Embolization vs Transarterial Embolization Alone for Hepatocellular Carcinoma Patients: A Phase 2 Randomized Clinical Trial. [PDF]
J Hepatocell Carcinoma, 2023 Jia Guo,1 Xuli Bao,1 Fuquan Liu,2 Jiang Guo,3 Yifan Wu,2 Fang Xiong,1 Jun Lu1 1Hepatology and Cancer Biotherapy Ward, Beijing YouAn Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Interventional Therapy, Beijing ...
Guo J +6 more
europepmc +2 more sources
Invariant Natural Killer T Cell Subsets-More Than Just Developmental Intermediates. [PDF]
Front Immunol, 2018 Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines.
Krovi SH, Gapin L.
europepmc +2 more sources
Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice. [PDF]
Nat Commun, 2023 Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Han SM +15 more
europepmc +2 more sources
invariant Natural Killer T cell therapy as a novel therapeutic approach in hematological malignancies. [PDF]
Front TransplantInvariant Natural Killer T cell therapy is an emerging platform of immunotherapy for cancer treatment. This unique cell population is a promising candidate for cell therapy for cancer treatment because of its inherent cytotoxicity against CD1d positive ...
Boonchalermvichian C +5 more
europepmc +2 more sources
CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond. [PDF]
Front Immunol, 2018 CD1d-restricted invariant natural killer T (iNKT) cells are considered an attractive target for cancer immunotherapy. Upon their activation by glycolipid antigen and/or cytokines, iNKT cells can induce direct lysis of tumor cells but can also induce an ...
King LA +3 more
europepmc +2 more sources
Mixed Signals: Co-Stimulation in Invariant Natural Killer T Cell-Mediated Cancer Immunotherapy. [PDF]
Front Immunol, 2017 Invariant natural killer T (iNKT) cells are an integral component of the immune system and play an important role in antitumor immunity. Upon activation, iNKT cells can directly kill malignant cells as well as rapidly produce cytokines that stimulate ...
Shissler SC, Lee MS, Webb TJ.
europepmc +2 more sources
Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection. [PDF]
Front Immunol, 2018 A family of transcription factors known as E proteins, and their antagonists, Id proteins, regulate T cell differentiation at critical developmental checkpoints.
Roy S +8 more
europepmc +2 more sources
Peripheral Dopamine Controlled by Gut Microbes Inhibits Invariant Natural Killer T Cell-Mediated Hepatitis. [PDF]
Front Immunol, 2018 Neurotransmitters have been shown to regulate immune responses, and thereby are critically related to autoimmune diseases. Here we showed that depletion of dopaminergic neurons significantly promoted activation of hepatic iNKT cells and augmented ...
Xue R +8 more
europepmc +2 more sources
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer. [PDF]
Cell Stem Cell, 2019 Zhu Y +43 more
europepmc +2 more sources
Primary Mouse Invariant Natural Killer T (iNKT) Cell Purification and Transduction
Bio-Protocol, 2023 Invariant natural killer T (iNKT) cells are a non-conventional T-cell population expressing a conserved semi-invariant T-cell receptor (TCR) that reacts to lipid antigens, such as α-galactosyl ceramide (α-GalCer), presented by the monomorphic molecule ...
Gloria Delfanti +2 more
doaj +1 more source