Results 21 to 30 of about 13,897 (209)

CD1d expression and invariant NKT cell responses in herpesvirus infections

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor (TCR) and surface markers shared with the natural killer cell lineage.
Rusung eTan
doaj   +1 more source

The Role of Autophagy in iNKT Cell Development

Frontiers in Immunology, 2018
CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens.
Guan Yang, John P. Driver, Luc Van Kaer
doaj   +1 more source

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

Nature Communications, 2020
Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of ...
Beth Lucas, Andrea J. White, Emilie J. Cosway, Sonia M. Parnell, Kieran D. James, Nick D. Jones, Izumi Ohigashi, Yousuke Takahama, William E. Jenkinson, Graham Anderson   +9 more
doaj   +1 more source

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70

Nature Communications, 2018
Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ...
Meng Zhao, Mattias N. D. Svensson, Koen Venken, Ashu Chawla, Shu Liang, Isaac Engel, Piotr Mydel, Jeremy Day, Dirk Elewaut, Nunzio Bottini, Mitchell Kronenberg   +10 more
doaj   +1 more source

Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets

Nature Communications, 2016
A recent advance in invariant natural killer T cell (iNKT) cell biology is their classification into iNKT1, iNKT2 and iNKT17 subsets. Here the authors provide a transcriptomic analysis of these thymic subsets from Balb/c and C57Bl/6 mice that supports ...
Hristo Georgiev, Inga Ravens, Charaf Benarafa, Reinhold Förster, Günter Bernhardt   +4 more
doaj   +1 more source

Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Frontiers in Immunology, 2023
Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of
Andrew Kent, Andrew Kent, Andrew Kent, Lyndsey S. Crump, Eduardo Davila, Eduardo Davila, Eduardo Davila, Eduardo Davila   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

TCR signal strength controls thymic differentiation of iNKT cell subsets

Nature Communications, 2018
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces ...
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin   +15 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets

Frontiers in Immunology, 2018
In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules.
Haiguang Wang, Kristin A. Hogquist
doaj   +1 more source