Results 11 to 20 of about 13,897 (209)

Corrigendum: CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond. [PDF]

Front Immunol, 2018
King LA, Lameris R, de Gruijl TD, van der Vliet HJ.   +3 more
europepmc   +2 more sources

Natural killer T cell and pathophysiology of asthma [PDF]

Korean Journal of Pediatrics, 2010
Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called V?#7284;J?#7288; in mice or Va24 in humans ...
Gwang Cheon Jang
doaj   +1 more source

Invariant natural killer T cells minimally influence gut microbiota composition in mice

Gut Microbes, 2022
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey   +10 more
doaj   +1 more source

Invariant natural killer T cell agonist modulates experimental focal and segmental glomerulosclerosis. [PDF]

PLoS ONE, 2012
A growing body of evidence demonstrates a correlation between Th2 cytokines and the development of focal and segmental glomerulosclerosis (FSGS). Therefore, we hypothesized that GSL-1, a monoglycosylceramide from Sphingomonas ssp.
Rafael L Pereira, Vanessa O Reis, Patricia Semedo, Bruna N Buscariollo, Cassiano Donizetti-Oliveira, Marcos A Cenedeze, Maria Fernanda Soares, Alvaro Pacheco-Silva, Paul B Savage, Niels O S Câmara, Alexandre C Keller   +10 more
doaj   +1 more source

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells

Nature Communications, 2020
Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi, Jingjing Zhang, Mary Jessamine Michaels-Foster, Tonya Brunetti, Liyen Loh, James Scott-Browne, Laurent Gapin   +6 more
doaj   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer

BMC Cancer, 2018
Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama, Yoshitaka Okamoto   +7 more
doaj   +1 more source

Targeting adrenergic receptors to mitigate invariant natural killer T cells-induced acute liver injury

iScience, 2023
Summary: Invariant Natural Killer T (iNKT) cell activation by α-galactosylceramide (αGC) potentiates cytotoxic immune responses against tumors. However, αGC-induced liver injury is a limiting factor for iNKT-based immunotherapy.
Michelangelo Bauwelz Gonzatti, Beatriz Marton Freire, Maísa Mota Antunes, Gustavo Batista de Menezes, Jhimmy Talbot, Jean Pierre Schatzmann Peron, Alexandre Salgado Basso, Alexandre Castro Keller   +7 more
doaj   +1 more source

Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells

Frontiers in Immunology, 2018
Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner, Paul Klenerman, Paul Klenerman, Nicholas M. Provine   +3 more
doaj   +1 more source

Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential

Frontiers in Immunology, 2017
Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor (TCR) [invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes that recognize glycolipids presented by CD1d molecules.
Christian W. Keller, Stefan Freigang, Jan D. Lünemann, Jan D. Lünemann   +3 more
doaj   +1 more source