Results 41 to 50 of about 8,083 (126)

Specific deletion of LDL receptor-related protein on macrophages has skewed in vivo effects on cytokine production by invariant natural killer T cells. [PDF]

PLoS ONE, 2014
Expression of molecules involved in lipid homeostasis such as the low density lipoprotein receptor (LDLr) on antigen presenting cells (APCs) has been shown to enhance invariant natural killer T (iNKT) cell function. However, the contribution to iNKT cell
Roman Covarrubias, Ashley J Wilhelm, Amy S Major   +2 more
doaj   +1 more source

Discovery of Avian TCRVβ2+ T Cells Recognizing the Endogenous Ganglioside via a chCD1.1‐Dependent Pathway

European Journal of Immunology, Volume 56, Issue 10, October 2026.
We present the first report of chicken lipid‐reactive, NKT‐like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen‐presenting cells. This activation induces a rapid cytokine response from avian lipid‐reactive T cells, offering a universal target for lipid‐adjuvanted poultry vaccines.
Nitin Kamble, Faisal R Anjum, Shahriar Behboudi   +2 more
wiley   +1 more source

Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells

Communications Biology, 2023
After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been elucidated.
Tomonori Iyoda, Kanako Shimizu, Takaho Endo, Takashi Watanabe, Ichiro Taniuchi, Honoka Aoshima, Mikiko Satoh, Hiroshi Nakazato, Satoru Yamasaki, Shin-ichiro Fujii   +9 more
doaj   +1 more source

Mucosal‐Associated Invariant T Cells in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
The roles of MAIT cells in health and disease and their therapeutic applications. In healthy individuals, riboflavin metabolites secreted by commensal bacteria at mucosal sites are presented by MR1, leading to the activation of MAIT cells. Activated MAIT cells can maintain the barrier integrity of mucosal tissues in a steady state or migrate to the ...
Yu Zhao, Feng‐Mi Ou, Dan Liang, Yang Gao, Qing‐Qing Li, Yi‐Qun Kuang   +5 more
wiley   +1 more source

Immune‐Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy

MedComm, Volume 7, Issue 10, October 2026.
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Pin Guo, Yizhao Xie, Rui Song, Mengdi Yang, Zhen Lin, Chao Guan, Zechen Wang, Jin Wen, Guang‐Liang Chen   +8 more
wiley   +1 more source

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation

Cell Reports, 2016
iNKT cells are a subset of innate T cells that recognize glycolipids presented on CD1d molecules and protect against bacterial infections, including S. pneumoniae.
Ajitha Thanabalasuriar, Arpan S. Neupane, Jing Wang, Matthew F. Krummel, Paul Kubes   +4 more
doaj   +1 more source

A Chemically Defined Four‐Component Self‐Adjuvanting Tn Vaccine Activating Mincle, FcγR, and CD206 for Enhanced Antitumor Immunity

Advanced Science, Volume 13, Issue 52, 18 September 2026.
A fully synthetic four‐component vaccine has been developed combining Tn antigen, vizantin (Mincle agonist), rhamnose (antibody recruitment), and mannose (CD206 targeting). By synergistically activating Mincle, FcγR, and CD206 pathways, it elicits strong IgG switching and cytotoxic T‐cells, significantly inhibiting tumors in mice.
Wenbo Ming, Renyu Zhang, Xiaohui Li, Guiqi Li, Yu Niu, Deying Yang, Xiang Luo, Jun Liao, Zhongqiu Liu, Guochao Liao   +9 more
wiley   +1 more source

CXCL10/SLC11A1 Axis Exacerbates Septic Liver Injury by Regulating Neutrophil Extracellular Traps Formation to Drive Macrophage Pro‑Inflammatory Polarization

Advanced Science, Volume 13, Issue 54, 28 September 2026.
In sepsis‐induced liver injury, marked neutrophil infiltration correlates with disease severity. Neutrophil SLC11A1 drives intracellular Fe2+ and ROS via the Fenton reaction, promoting NETs formation. Hepatocyte‐derived CXCL10 recruits neutrophils and activates the JAK/STAT1/SLC11A1 axis, enhancing NETs‐mediated inflammation.
Haiping Lin, Shicong Zheng, Pei Song, Jie Chang, Zewei Chen, Cang Li, Min Yu, Lude Wang, Shian Yu   +8 more
wiley   +1 more source

Analysis of the Role of N‐Linked Glycans on Human CD1d Molecules

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Syamdas Bandyopadhyay, Sayantan Pradhan
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, Volume 2, Issue 3, September 2026.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source