Results 51 to 60 of about 9,712 (187)
, 2021 Innate-like T cell populations expressing conserved TCRs play critical roles in immunity through diverse developmentally acquired effector functions.
Colomé-Tatché, M. +16 more
core +2 more sources
Immunoregulation by iNKT Cells
YAKUGAKU ZASSHI, 2009 NKT cells are defined as cells co-expressing of the natural killer receptors such as NK1.1 or NKR-P1A (CD161) and a T cell receptor (TCR). Although NK1.1(+) TCR(+) lymphocytes are heterogeneous, we focus on two distinct T cell subsets express invariant T cell receptor alpha chains, Valpha14-Jalpha18(Valpha14i) and Valpha19-Jalpha33(Valpha19i ...
openaire +3 more sources
Frontiers in Immunology, 2019 Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model ...
Alexander Schäfer +7 more
doaj +1 more source
Cytokine dependent and independent iNKT cell activation [PDF]
Cytokine, 2010 Invariant NKT (iNKT) cells have been extensively studied throughout the last decade due to their ability to polarize and amplify the downstream immune response. Only recently however, have the various mechanisms underlying NKT cell activation begun to unfold.
Emma C, Reilly +2 more
openaire +2 more sources
A humanized monoclonal antibody specific for invariant Natural Killer T (iNKT) cells for in vivo depletion. [PDF]
PLoS ONE, 2013 Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain (Vα24-Jα18) paired with a specific beta chain, Vβ11.
Felix Scheuplein +5 more
doaj +1 more source
Frontiers in Immunology, 2020 Invariant natural killer T (iNKT) cells are innate-like T lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines.
Nathan G. F. Leborgne +7 more
doaj +1 more source
iNKT regulation of NK, T cell, and B cell activation.
, 2013 Presentation of lipid antigen to iNKT cells by DCs leads to iNKT activation and upregulation of CD40L. CD40–CD40L interactions and iNKT cytokine secretion promotes DC activation and maturation, which in turn leads to antigen cross-presentation and ...
Yoav Keynan (187593) +2 more
core +1 more source
Using agonists for iNKT cells in cancer therapy
Molecular Immunology, 2021 The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice through the specific stimulation of type I NKT (iNKT) cells has prompted extensive investigation to translate this finding to the clinic. However, low frequencies of iNKT cells in cancer patients and their hypo-responsiveness to repeated stimulation have been seen as
Gavin F. Painter +2 more
openaire +2 more sources
Surface phenotypes of expanded iNKT cell subsets.
, 2013 A, Percentage expression of CD56, CD161, NKG2D and CD25 by electronically-gated CD4+, CD8α+ and DN cells within expanded iNKT cell lines. Horizontal lines show means; p values in shaded boxes show multiple comparisons of cell frequencies using the ...
Vincent O'Reilly (215467) +8 more
core +1 more source
Frontiers in Chemistry, 2019 Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Alan Chuan-Ying Lai +7 more
doaj +1 more source