Results 51 to 60 of about 8,083 (126)

Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation

Cell Reports, 2019
Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park, Devon T. DiPalma, Juntae Kwon, Juliet Fink, Jung-Hyun Park   +4 more
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, Volume 2, Issue 3, September 2026.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances

MedComm, Volume 7, Issue 9, September 2026.
Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait, Anna Cargnoni, Franco Scaldaferri, Loris Lopetuso, Antonietta Rosa Silini, Ornella Parolini   +5 more
wiley   +1 more source

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

Nature Communications
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for ...
Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai   +19 more
doaj   +1 more source

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

eLife, 2019
Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells.
Rebeca Jimeno, Marta Lebrusant-Fernandez, Christian Margreitter, Beth Lucas, Natacha Veerapen, Gavin Kelly, Gurdyal S Besra, Franca Fraternali, Jo Spencer, Graham Anderson, Patricia Barral   +10 more
doaj   +1 more source

iNKT cells suppress the CD8+ T cell response to a murine Burkitt's-like B cell lymphoma. [PDF]

PLoS ONE, 2012
The T cell response to B cell lymphomas differs from the majority of solid tumors in that the malignant cells themselves are derived from B lymphocytes, key players in immune response.
Ryan L Bjordahl, Laurent Gapin, Philippa Marrack, Yosef Refaeli   +3 more
doaj   +1 more source

Immunomodulatory Effects of Tokishakuyakusan on Progesterone Withdrawal–Induced Uterine Inflammation in Pregnant Mice

American Journal of Reproductive Immunology, Volume 96, Issue 3, September 2026.
ABSTRACT Problem Tokishakuyakusan (TSS) is a traditional Japanese Kampo medicine widely used to support pregnancy; however, its molecular mechanisms remain poorly understood. This study aimed to elucidate the progesterone‐related immunomodulatory mechanisms underlying the pregnancy‐supportive effects of TSS using a mouse model of progesterone ...
Takeshi Nagamatsu, Manami Yanagisawa, Yohei Tokita, Keisuke Nakajima, Tomohiro Otani, Ayumi Taguchi, Mari Ichinose, Keiich Kumasawa, Takayuki Iriyama   +8 more
wiley   +1 more source

Clinical Application of iNKT Cell-mediated Anti-tumor Activity Against Lung Cancer and Head and Neck Cancer

Frontiers in Immunology, 2018
Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to ...
Mariko Takami, Fumie Ihara, Fumie Ihara, Shinichiro Motohashi   +3 more
doaj   +1 more source

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, Volume 81, Issue 9, Page 3236-3249, September 2026.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source