Results 61 to 70 of about 16,069 (248)
Frontiers in Immunology, 2019 Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model ...
Alexander Schäfer +7 more
doaj +1 more source
Untangling iNKT Cell Function in Adipose Tissue Homeostasis [PDF]
Cell Metabolism, 2020 iNKT cells are important regulatory cells in metabolic health and disease. In this issue of Cell Metabolism, LaMarche et al. (2020) clarify the origin and heterogeneity of these unconventional T cells and identify the specific signals in adipose tissues that direct their function.
Ruth A, Franklin, Ruslan, Medzhitov
openaire +2 more sources
Frontiers in Immunology, 2020 Invariant natural killer T (iNKT) cells are innate-like T lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines.
Nathan G. F. Leborgne +7 more
doaj +1 more source
A humanized monoclonal antibody specific for invariant Natural Killer T (iNKT) cells for in vivo depletion. [PDF]
PLoS ONE, 2013 Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain (Vα24-Jα18) paired with a specific beta chain, Vβ11.
Felix Scheuplein +5 more
doaj +1 more source
Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]
, 2018 Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S. +8 more
core +5 more sources
Zeb2 regulates differentiation of long-lived effector of invariant natural killer T cells
Communications Biology, 2023 After activation, some invariant natural killer T (iNKT) cells are differentiated into Klrg1+ long-lived effector NKT1 cells. However, the regulation from the effector phase to the memory phase has not been elucidated.
Tomonori Iyoda +9 more
doaj +1 more source
Galactosylsphingamides : new α-GalCer analogues to probe the F’-pocket of CD1d [PDF]
, 2017 Invariant Natural Killer T-cells (iNKT-cells) are an attractive target for immune response modulation, as upon CD1d-mediated stimulation with KRN7000, a synthetic alpha-galactosylceramide, they produce a vast amount of cytokines.
Decruy, Tine +9 more
core +1 more source
T cells, the next big target in axSpA?
Arthritis &Rheumatology, Accepted Article.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
iNKT Cells and Their Potential Lipid Ligands during Viral Infection [PDF]
, 2015 Invariant natural killer T (iNKT) cells are a unique population of lipid-reactive CD1d-restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya Opasawatchai +1 more
core +1 more source
iNew Medicine, EarlyView.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source