Results 81 to 90 of about 9,712 (187)

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, Volume 2, Issue 2, Page 280-308, June 2026.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

The My(c)stery of iNKT cell ontogeny [PDF]

Cell Cycle, 2009
Invariant V alpha 14 bearing natural killer T cells (iNKT) cells constitute a subset of lymphocytes that recognize lipid-based ligands presented by the non-classical MHC class I-like molecule CD1d and responds with rapid cytokine production. Despite their multiple implications in regulating immune responses, pertaining to cancer and auto-immunity, the ...
Marei, Dose, Fotini, Gounari
openaire   +2 more sources

Cytokine secretion by iNKT cell subsets.

, 2013
Highly-purified populations of CD4+, DN and CD8α+ iNKT cells were cultured in medium alone, with iDC or HeLa-CD1d cells in the absence or presence of 100 ng/ml α-GalCer, or with PMA and ionomycin for 24 hours. Levels of IFN-γ, TNFα, IL-1β, IL-2, IL-4, IL-
Vincent O'Reilly (215467), Shijuan G. Zeng (337651), Gabriel Bricard (234970), John Jackson (377041), Conleth Feighery (337653), Andrew E. Hogan (337652), Steven A. Porcelli (47915), Ann Atzberger (219124), Derek G. Doherty (337654)   +8 more
core   +1 more source

Nanotechnology Meets Immunotherapy: Crosstalks Against Cancer

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Background The convergence of nanotechnology and immunotherapy has ushered in a transformative era in cancer treatment, offering new strategies to overcome pharmacokinetic limitations and immune evasion associated with conventional therapies. While immunotherapy, spanning checkpoint inhibitors, adoptive cell transfer, and cancer vaccines, has ...
Nima Javanmehr, Asal Moazzami Ashtyani, Robabehbeygom Ghafelehbashi, Fateme Mousavi, Hossein Teimouri   +4 more
wiley   +1 more source

Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model [PDF]

Scientific Reports, 2018
AbstractGraphene oxide (GO) modulates the functions of antigen-presenting cells including dendritic cells (DCs). Although carbon nanotubes affect expression of the MHC class I-like CD1d molecule, whether GO can influence immune responses of CD1d-dependent invariant natural killer T (iNKT) cells remains unclear. Here, we investigated the impact of GO on
Lee, Sung Won, Park, Hyun Jung, Van Kaer, Luc, Hong, Suklyun, Hong, Seokmann   +4 more
openaire   +2 more sources

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells

eLife, 2019
Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells.
Rebeca Jimeno, Marta Lebrusant-Fernandez, Christian Margreitter, Beth Lucas, Natacha Veerapen, Gavin Kelly, Gurdyal S Besra, Franca Fraternali, Jo Spencer, Graham Anderson, Patricia Barral   +10 more
doaj   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease

, 2017
Invariant NKT (iNKT) cells can be activated to stimulate a broad inflammatory response. In murine models of sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from vaso-occlusion.
Ataga, Kenneth I, Majerus, Elaine, Elaine Majerus (3713170), Field, Joshua J., Field, Joshua J, Robert Mashal, Schaub, Robert, Joshua J Field, Kenneth I. Ataga (335509), Vichinsky, Elliot, Nathan, David G., Nathan, David, Kenneth I Ataga, Robert Schaub (464072), Robert Mashal (464071), Ataga, Kenneth I., Robert Schaub, Elliot P. Vichinsky (3713173), Elliot P Vichinsky, Field, Joshua, David G Nathan, Vichinsky, Elliot P., Elaine Majerus, Ataga, Kenneth, David G. Nathan (466972), Joshua J. Field (176969), Nathan, David G, Vichinsky, Elliot P, Mashal, Robert   +28 more
core   +1 more source

Innate-like control of human iNKT cell autoreactivity via the hypervariable CDR3beta loop [PDF]

, 2010
Invariant Natural Killer T cells (iNKT) are a versatile lymphocyte subset with important roles in both host defense and immunological tolerance. They express a highly conserved TCR which mediates recognition of the non-polymorphic, lipid-binding molecule
Asparuhova, Maria B., Joseph P Sanderson, Richard R. Schmidt, Sanderson Joseph P., Peter M. Villiger, Richard R Schmidt, Gadola, Stephan D., Daniel Schümperli, Joseph P. Sanderson, Lissin, Nikolai M., Nikolai M Lissin, Gopal R Bommineni, Schmidt, Richard R., Jakobsen, Bent K., Schmidt, Richard R, Maria B. Asparuhova, Matulis Gediminas, Stephan D Gadola, Schmidt Richard R., Villiger Peter M., Asparuhova, Maria B, Schümperli Daniel, Matulis, Gediminas, Lissin Nikolai M., Gediminas Matulis, Sanderson, Joseph P., Jakobsen Bent K., Stephan D. Gadola, Sanderson, Joseph P, Asparuhova Maria B., Bommineni, Gopal R, Maria B Asparuhova, Gopal R. Bommineni, Schumperli, Daniel, Jakobsen, Bent K, Lissin, Nikolai M, Bommineni, Gopal R., Villiger, Peter M, Peter M Villiger, Gadola Stephan D., Gadola, Stephan D, Bent K. Jakobsen, Villiger, Peter M., Bent K Jakobsen, Bommineni Gopal R., Nikolai M. Lissin   +45 more
core   +1 more source

Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

Communications Biology
Invariant NKT (iNKT) cells have a T-cell receptor that is common to all individuals and are activated by recognizing glycolipids on MHC class I-like CD1d molecules.
Sara Shiina, Tatsuki Ueda, Shoichi Iriguchi, Yasushi Uemura, Shin Kaneko   +4 more
doaj   +1 more source