Results 91 to 100 of about 9,712 (187)

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients – PART 1: Risk Factors, Clinical Impact and Immune Response

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan, Emily Blyth, Gaurav Sutrave, Michelle K. Yong, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Lauren Stern   +7 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Activation of PPARγ Specifies a Dendritic Cell Subtype Capable of Enhanced Induction of iNKT Cell Expansion

, 2004
Little is known of the transcriptional events controlling the differentiation and function of dendritic cells (DC). We found that the ligand-activated transcription factor Peroxisome Proliferator Activated Receptor γ (PPARγ) is immediately upregulated ...
Jin Seol Im, Istvan Szatmari, Balazs Dezso, Im, Jin Seol, Gogolak, Peter, Peter Gogolak, Dezso, Balazs, Rajnavolgyi, Eva, Nagy, Laszlo, Szatmari, Istvan, Eva Rajnavolgyi, Laszlo Nagy   +11 more
core   +1 more source

Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.

PLoS ONE, 2014
Invariant NKT cells are innate lymphocytes with a broad tissue distribution. Here we demonstrate that iNKT cells reside in the central nervous system (CNS) in the absence of inflammation.
Lennart T Mars, Magali Mas, Lucie Beaudoin, Jan Bauer, Maria Leite-de-Moraes, Agnès Lehuen, Jean-Francois Bureau, Roland S Liblau   +7 more
doaj   +1 more source

Mixed Signals: T Cells as Architects of IgE Immunity

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney, Wallace P. Bezerra, Stephanie C. Eisenbarth, Adam Williams   +3 more
wiley   +1 more source

miR-17-92 family clusters control iNKT cell ontogenesis via modulation of TGF-β signaling [PDF]

, 2016
Invariant natural killer T cells (iNKT) cells are T lymphocytes displaying innate effector functions, acquired through a distinct thymic developmental program regulated by microRNAs (miRNAs).
Cittaro, Davide, E. Stupka, L. Tian, P. Provero, Provero, Paolo, Abrignani, Sergio, Tian, Lei, Stupka, Elia, J. M. G. Manteiga, G. Casorati, M. Fedeli, C. Xiao, D. Cittaro, Liston, Adrian, Rossetti, Grazisa, A. Liston, Xiao, Changchun, Casorati, Giulia, P. Dellabona, Riba, Michela, Fedeli, Maya, Pagani, Massimiliano, Garcia Manteiga, Jose Manuel, V. Viganò, Viganò, Valentina, M. Pagani, G. Rossetti, Dellabona, Paolo, S. Abrignani, M. Riba   +29 more
core   +1 more source

Functions of CD1d-Restricted Invariant Natural Killer T Cells in Antimicrobial Immunity and Potential Applications for Infection Control

Frontiers in Immunology, 2018
CD1d-restricted invariant natural killer T (iNKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans.
Yuki Kinjo, Shogo Takatsuka, Naoki Kitano, Shun Kawakubo, Masahiro Abe, Keigo Ueno, Yoshitsugu Miyazaki   +6 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

MiR150 over-expression impairs iNKT cell development, maturation, and function

, 2017
CD1d-restricted invariant natural killer T (iNKT) cells play an important role in the regulation of diverse immune responses. MicroRNAs have been shown to be critically involved in iNKT cell development, maturation, and function, but the roles of ...
Zhou, Li, Wu, Xiaojun, Mi, Qing-Sheng, Wang, Jie   +3 more
core  

Chronic alcohol consumption enhances iNKT cell maturation and activation

, 2015
Alcohol consumption exhibits diverse effects on different types of immune cells. NKT cells are a unique T cell population and play important immunoregulatory roles in different types of immune responses.
Zhang, Faya, Faya Zhang, Zhaohui Zhu, Luong, Dung, Dung Luong, Zhu, Zhaohui, Zhang, Hui, Meadows, Gary G, Hui Zhang, Gary G. Meadows   +9 more
core   +1 more source