Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia [PDF]
, 2014 SignificanceInvariant natural killer T cells (iNKT) have been found primarily patrolling inside blood vessels in the liver, where they respond to bacterial glycolipids presented by CD1d on liver macrophages. We show joint iNKT cells are localized outside
A. Marques +33 more
core +1 more source
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Invariant NKT cells regulate the CD8 T cell response during Theiler's virus infection.
PLoS ONE, 2014 Invariant NKT cells are innate lymphocytes with a broad tissue distribution. Here we demonstrate that iNKT cells reside in the central nervous system (CNS) in the absence of inflammation.
Lennart T Mars +7 more
doaj +1 more source
An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
core +1 more source
Diverse immunological roles of liver‐resident immune cells in liver diseases
Precision Medical Sciences, Volume 15, Issue 1, Page 4-17, March 2026.Based on their origin and functional characteristics, LRICs can be classified into four categories. These cells differ in the focus of their immune functions in liver diseases, yet all exhibit the characteristic of functional bidirectionality.
Zhengyi Fan +4 more
wiley +1 more source
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems [PDF]
, 2011 BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin.
Daniela Pende +5 more
core +3 more sources
Andrology, Volume 14, Issue 3, Page 822-832, March 2026.ABSTRACT Background Lichen sclerosus is a chronic, inflammatory, scarring disease of the skin that manifests mostly in the genital region. Objective We studied the histomorphological characteristics, grade, and pattern of inflammation in male pediatric patients with lichen sclerosus.
Valerie Flammang +10 more
wiley +1 more source
Frontiers in Immunology, 2018 CD1d-restricted invariant natural killer T (iNKT) cells are innate-type lymphocytes that express a T-cell receptor (TCR) containing an invariant α chain encoded by the Vα14 gene in mice and Vα24 gene in humans.
Yuki Kinjo +6 more
doaj +1 more source
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]
, 2019 Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie +27 more
core +3 more sources
Role of innate T cells in anti-bacterial immunity [PDF]
, 2015 Innate T cells are a heterogeneous group of αβ and γδ T cells that respond rapidly (
Aggarwal +100 more
core +1 more source