Results 121 to 130 of about 16,069 (248)

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells [PDF]

, 2013
Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral ...
A Bendelac, A Bendelac, A Reschner, AK Savage, AM Fahrer, B Johnston, BM Sullivan, BN Weber, C Grégoire, C Kuylenstierna, C Paget, D Kovalovsky, DI Godfrey, DI Godfrey, DM Andrews, E Vivier, Gerald F Watts, H Sun, H Watarai, HD Marshall, J Shires, JE Gumperz, JL Matsuda, JL Matsuda, JL Matsuda, JM Coquet, Joonsoo Kang, K Inagaki-Ohara, K Miyazaki, L Gattinoni, L Gattinoni, LE Gordy, LL Lanier, M Brigl, M Brigl, M Brigl, M Maeda, M Salio, MA Cooper, Manfred Brigl, Michael B Brenner, MJ Townsend, MS Vincent, Nadia R Cohen, NC Fernandez, NR Cohen, NY Crowe, P Kastner, Patrick J Brennan, PD Thomas, PJ Brennan, RL O'Brien, S Honma, S Yu, T Kawamura, T Ota, T Walzer, T Willinger, Tal Shay, TSP Heng, V Cerundolo, W Huang da, X Yue, Y Makino   +63 more
core   +3 more sources

Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf [PDF]

, 2017
journal ...
HAMADA Michito, Miaw Shi-Chuen, Ohtsuka Shigeo, TAKAHASHI Satoru, Yoh Keigyou, Yu Jhang-Sian   +5 more
core   +1 more source

Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function [PDF]

, 2018
MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that ...
Bradbury, Brossay, Chen, Crosby, Deng, Gurdyal S. Besra, Hughes, Ichimiya, Jamie Rossjohn, Jennifer L. Matsuda, Jingjing Zhang, Jérôme Le Nours, Kathryn D. Tuttle, Laurent Gapin, Natacha Veerapen, Park, Romain Bedel, S. Harsha Krovi, Srinivasan Sundararaj, T. Praveena, Yogesh Khandokar, Zajonc, Zhang   +22 more
core   +4 more sources

A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands [PDF]

, 2013
Depending on the environment and the activating glycolipids, iNKT cells are known to induce T-helper 1 and/or T-helper 2 cytokines. This highly versatile nature makes these innate-like cells very interesting targets for immunomodulation.
ASPESLAGH, SANDRINE, De Spiegeleer, Anton, Elewaut, Dirk, Stalmans, Sofie, Van Calenbergh, Serge, Van Den Noortgate, Nele, Vandekerckhove, Matthias, Venken, Koen, Wynendaele, Evelien   +8 more
core  

Invariant NKT Cell Response to Dengue Virus Infection in Human [PDF]

, 2014
BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF).
Chan-in, W, Duangchinda, T, Limpitikul, W, Malasit, P, Matangkasombut, P, Mongkolsapaya, J, Opasawaschai, A, Pongchaikul, P, Screaton, G, Tangthawornchaikul, N, Vasanawathana, S   +10 more
core   +4 more sources

The Role of Invariant Natural Killer T Cells in Dendritic Cell Licensing, Cross-Priming, and Memory CD8+ T Cell Generation [PDF]

, 2015
New vaccination strategies focus on achieving CD8+ T cell (CTL) immunity rather than on induction of protective antibody responses. While the requirement of CD4+ T (Th) cell help in dendritic cell (DC) activation and licensing, and in CTL memory ...
Catherine Gottschalk, Christian Kurts, Elisabeth Mettke   +2 more
core   +2 more sources

Hiding Lipid Presentation: Viral Interference with CD1d-Restricted Invariant Natural Killer T (iNKT) Cell Activation

Viruses, 2012
The immune system plays a major role in protecting the host against viral infection. Rapid initial protection is conveyed by innate immune cells, while adaptive immunity (including T lymphocytes) requires several days to develop, yet provides high ...
Maaike E. Ressing, Anna M. Gram, Ruben J. Geerdink, Daniëlle Horst, Arie J. Stoppelenburg   +4 more
doaj   +1 more source

Genetic Regulation of NKT Cell Function [PDF]

, 2017
NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core   +1 more source

Supplementary Table S1 from Safety and clinical response to combined immunotherapy with autologous iNKT cells and PD-1+CD8+ T cells in patients failing first-line chemotherapy in stage IV pancreatic cancer

, 2023
Jing Wang, Xiaobo Cheng, Yanling Jin, Bili Xia, Ran Qin, Wei Zhang, Huiliang Hu, Xiaoting Mao, Liting Zhou, Yan Jia, Xiaoyan Zhang, Jianqing Xu   +11 more
openalex   +1 more source

Rat iNKT Cells: Phenotype and Function [PDF]

, 2010
iNKT Zellen sind eine Population von T Zellen mit einigen Besonderheiten. Anders als die meisten αβ T Zellen, deren T Zell Rezeptoren (TZRs) für von hochpolymorphen MHC Molekülen präsentierte Peptide spezifisch sind, erkennen iNKT Zellen Glycolipide die von CD1d, einem nicht polymorphem MHC-I artigen Moleküle, präsentiert werden.
openaire   +1 more source