Results 1 to 10 of about 8,214 (116)

Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers [PDF]

Nature Communications
iNKT cells are emerging as a highly promising immunotherapy platform for the treatment of cancer. To maximise the anti-cancer activity of CAR-iNKT against the blood cancer multiple myeloma we investigated optimal CAR designs and their combination with ...
Kanagaraju Ponnusamy, Klesti Karaxhuku, Yuchao Jiang, Lyra Randzavola, Hongwei Ren, Ilia Leontari, Bryan Lye, Mehmood Zaidi, Edward J. Bartlett, Edward W. Tate, Vasileios Pardalis, Dimitrios Leonardos, Reza Nadafi, Irene Sarkar, Rogier M. Reijmers, Marco Bua, Maria Atta, Alexia Katsarou, Irene AG Roberts, Aristeidis Chaidos, Anastasios Karadimitris   +20 more
doaj   +2 more sources

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Cell Reports, 2018
Summary: Heterotypic cellular and molecular interactions in the tumor microenvironment (TME) control cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells control prostate cancer (PCa) progression by sculpting the ...
Andrea Salonia, Ferdinando Pucci, Paolo Dellabona   +2 more
exaly   +3 more sources

Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells [PDF]

Stem Cell Research & Therapy
Invariant natural killer T (iNKT) cells, upon activation, exhibit antitumor roles by bridging innate and acquired immunity. To overcome the challenges in producing iNKT cells from patients with cancer, we previously developed allogeneic human induced ...
Takahiro Aoki, Midori Kobayashi, Momoko Okoshi, Munechika Yamaguchi, Hiroko Okura, Satoko Sasaki, Yoshie Sasako, Sachiko Kira, Yun-Hsuan Chang, Nayuta Yakushiji-Kaminatsui, Jafar Sharif, Masashi Matsuda, Masahiro Kiuchi, Kiyoshi Hirahara, Motoko Y. Kimura, Shinichiro Motohashi, Haruhiko Koseki   +16 more
doaj   +2 more sources

Melanoma causes phenotypic modulations and metabolic switches of iNKT cells influencing clinical outcomes [PDF]

Frontiers in Immunology
IntroductionInvariant NKT (iNKT) cells are crucial effectors in cancer immunosurveillance, due to their immunomodulatory potential through a broad range of effector and regulatory functions.
Emmanuelle Degeorges, Emmanuelle Degeorges, Stéphane Mouret, Pauline Girard, Pauline Girard, Camille Niveau, Camille Niveau, Mélanie Cettour-Cave, Mélanie Cettour-Cave, Eleonora Sosa Cuevas, Eleonora Sosa Cuevas, Florence De Fraipont, Julie Charles, Philippe Saas, Philippe Saas, Caroline Aspord, Caroline Aspord   +16 more
doaj   +2 more sources

Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy

Inflammation and Regeneration, 2023
Invariant natural killer T (iNKT) cells are a subset of innate-like T cells restricted by a major histocompatibility complex (MHC) class I-like molecule, CD1d.
Takahiro Aoki, Shinichiro Motohashi, Haruhiko Koseki   +2 more
doaj   +1 more source

Integrative scATAC-seq and scRNA-seq analyses map thymic iNKT cell development and identify Cbfβ for its commitment

Cell Discovery, 2023
Unlike conventional αβT cells, invariant natural killer T (iNKT) cells complete their terminal differentiation to functional iNKT1/2/17 cells in the thymus.
Jie Wang, Indra Adrianto, Kalpana Subedi, Tingting Liu, Xiaojun Wu, Qijun Yi, Ian Loveless, Congcong Yin, Indrani Datta, Derek B. Sant’Angelo, Mitchell Kronenberg, Li Zhou, Qing-Sheng Mi   +12 more
doaj   +1 more source

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes

Frontiers in Immunology, 2023
Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look, Daniel Burns, Ivo Tews, Ivo Tews, Ali Roghanian, Ali Roghanian, Salah Mansour, Salah Mansour   +7 more
doaj   +1 more source

Expansion of invariant natural killer T cells from systemic lupus erythematosus patients by alpha-Galactosylceramide and IL-15.

PLoS ONE, 2021
CD1d-restricted invariant natural killer T cells (iNKT cells) may play an important role in the pathogenesis of systemic lupus erythematosus (SLE). Interleukin (IL)-15 is a pro-inflammatory cytokine which is over-expressed in SLE patients. In the present
Chien-Ya Hsu, Yu-Shan Chueh, Ming-Ling Kuo, Pei-Tzu Lee, Hsiu-Shan Hsiao, Jing-Long Huang, Syh-Jae Lin   +6 more
doaj   +1 more source

Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor

Frontiers in Immunology, 2019
The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao, Huishan Tao, Lei Li, Lei Li, Ying Gao, Zehua Wang, Xiao-Ping Zhong, Xiao-Ping Zhong, Xiao-Ping Zhong   +8 more
doaj   +1 more source