Results 11 to 20 of about 8,233 (133)

Analysis of the Role of N-Linked Glycans on Human CD1d Molecules. [PDF]

Cell Biochem Funct
ABSTRACT CD1d is a cell‐surface expressed glycoprotein that presents a variety of lipid and glycolipid antigens to invariant natural killer T‐cells (iNKT). We have examined the role of the N‐linked glycans on the human CD1d (hCD1d) in modulating the responses of iNKT cells using a combination of cell‐free, cell‐based assays and in silico analyses ...
Bandyopadhyay S, Pradhan S.
europepmc   +2 more sources

Immune-Cell Dynamics in the Tumor Microenvironment: Implications for Cancer Therapy. [PDF]

MedComm (2020)
Immune‐cell dynamics in the tumor microenvironment converge on four major barriers to effective therapy: failed immune access, defective antigen visibility and priming, loss of effector maintenance, and suppressive tissue remodeling. These barriers emerge from local hypoxic, cytokine, metabolic, and stromal signals.
Guo P, Xie Y, Song R, Yang M, Lin Z, Guan C, Wang Z, Wen J, Chen GL.   +8 more
europepmc   +2 more sources

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Cell Discovery, 2022
Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi   +9 more
doaj   +1 more source

Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]

PLoS ONE, 2012
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li, Patricia Polacino, Raquel Garcia-Navarro, Shiu-Lok Hu, Moriya Tsuji   +4 more
doaj   +1 more source

Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]

PLoS ONE, 2013
Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu, Shudan Shen, Jialong Yang, Zhenwei Xia, Xiao-Ping Zhong   +4 more
doaj   +1 more source

Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells

Cell Reports, 2014
Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan, William Pooi-Kat Chong, Sze-Wai Ng, Nurhidayah Basri, Shengli Xu, Kong-Peng Lam   +5 more
doaj   +1 more source

Vam6 reduces iNKT cell function in tumor via modulating AMPK/mTOR pathways

Frontiers in Immunology, 2023
Activation of mTORC1 is essential for anti-tumor function of iNKT cells. The mechanisms underlying impaired mTORC1 activation in intratumoral iNKT cells remain unclear.
Shiyu Bai, Shiyu Bai, Qielan Wu, Qielan Wu, Shasha Zhu, Yuwei Zhang, Yuwei Zhang, Xuran Chen, Xuran Chen, Miya Su, Miya Su, Jun Pan, Jun Pan, Shuhang Li, Shuhang Li, Ting Yue, Linfeng Xu, Di Xie, Di Xie, Chenxi Tian, Chenxi Tian, Dan Zhao, Xiang Li, Xiang Li, Junjie Hou, Lu Wang, Sicheng Fu, Sicheng Fu, Yanhong Xue, Amin Jiang, Dong Li, Tao Xu, Zhigang Tian, Zhigang Tian, Zhigang Tian, Rongbin Zhou, Rongbin Zhou, Rongbin Zhou, Huimin Zhang, Huimin Zhang, Li Bai, Li Bai, Li Bai, Li Bai, Li Bai   +44 more
doaj   +1 more source

Distinct and overlapping effector functions of expanded human CD4+, CD8α+ and CD4-CD8α- invariant natural killer T cells. [PDF]

PLoS ONE, 2011
CD1d-restricted invariant natural killer T (iNKT) cells have diverse immune stimulatory/regulatory activities through their ability to release cytokines and to kill or transactivate other cells.
Vincent O'Reilly, Shijuan G Zeng, Gabriel Bricard, Ann Atzberger, Andrew E Hogan, John Jackson, Conleth Feighery, Steven A Porcelli, Derek G Doherty   +8 more
doaj   +1 more source

Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy

Frontiers in Immunology, 2018
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens presented by CD1d molecules.
Benjamin J. Wolf, Jiyoung Elizabeth Choi, Jiyoung Elizabeth Choi, Mark A. Exley, Mark A. Exley, Mark A. Exley   +5 more
doaj   +1 more source

Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-γ production in mice. [PDF]

PLoS ONE, 2012
During interaction with APCs, invariant (i) NKT cells are thought to be indirectly activated by TLR4-dependently activated APCs. However, whether TLR4 directly activates iNKT cells is unknown.
Ji Hyung Kim, Hye Sung Kim, Hye Young Kim, Sae Jin Oh, Doo Hyun Chung   +4 more
doaj   +1 more source