Results 31 to 40 of about 8,233 (133)
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Current Issues in Pharmacy and Medical SciencesVitamin D regulates not only bone metabolism but also many other processes, including the functioning of lymphocytes. Human T cells have a nuclear receptor for vitamin D (VDR).
Karamus Kornelia +5 more
doaj +1 more source
Stem Cell Research & Therapy, 2022 Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li +11 more
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Impact of sleep insufficiency and recovery on cancer development
Sleep Research, EarlyView.Abstract Sleep plays a critical role in overall health, and modern lifestyles, such as shift work and late‐night activities, can significantly impact sleep condition. Insufficient sleep has been associated with various adverse health outcomes, including an increased risk of tumor development.
Xiaxi Li, Chuanyuan Li, Yi Zhang
wiley +1 more source
Frontiers in Immunology, 2020 Invariant natural killer T (iNKT) cells are innate-like T lymphocytes cells that recognize glycolipid antigens associated with CD1d, non-classical antigen presenting proteins.
Abel Trujillo-Ocampo +8 more
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Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury
Cell Reports, 2023 Summary: Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d.
Cristhiane Favero Aguiar +20 more
doaj +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
eLife, 2023 Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While many studies show that the development and functions of innate and adaptive immune cells depend on their metabolic state ...
Jaemoon Koh +10 more
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Synovial Fluid Immune Cell Landscape in Juvenile Idiopathic Arthritis
European Journal of Immunology, Volume 56, Issue 10, October 2026.Synovial fluid immune cells in juvenile idiopathic arthritis were profiled using single‐cell multiomics and flow cytometry. The immune landscape in synovial fluid was markedly distinct from that of blood and was enriched for dendritic cells, CD56hi NK cells, γδ T cells, CD4+ T peripheral helper and regulatory T cells, tissue‐resident memory CD8+ T ...
Viola Pitkänen +10 more
wiley +1 more source
European Journal of Immunology, Volume 56, Issue 10, October 2026.We present the first report of chicken lipid‐reactive, NKT‐like TCRVβ2+ T cells that recognize the endogenous ganglioside GM3 presented by chCD1.1 on live antigen‐presenting cells. This activation induces a rapid cytokine response from avian lipid‐reactive T cells, offering a universal target for lipid‐adjuvanted poultry vaccines.
Nitin Kamble +2 more
wiley +1 more source