Results 51 to 60 of about 8,233 (133)
iNew Medicine, Volume 2, Issue 3, September 2026.ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little +12 more
wiley +1 more source
Inflammatory Bowel Disease: Mechanisms and Therapeutic Advances
MedComm, Volume 7, Issue 9, September 2026.Inflammatory bowel disease (IBD), encompassing ulcerative colitis and Crohn's disease, is a rising, multifactorial chronic disorder driven by dysregulated mucosal immunity in genetically susceptible individuals and influenced by environmental and microbial factors.
Andrea Papait +5 more
wiley +1 more source
Small, Volume 22, Issue 49, 1 September 2026.Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley +1 more source
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
eLife, 2019 Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells.
Rebeca Jimeno +10 more
doaj +1 more source
Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
JCI Insight, 2022 Invariant NK T (iNKT) cells are implicated in viral clearance; however, their role in hepatitis C virus (HCV) infection remains controversial. Here, iNKT cells were studied during different stages of HCV infection. iNKT cells from patients with acute HCV
Tina Senff +11 more
doaj +1 more source
American Journal of Reproductive Immunology, Volume 96, Issue 3, September 2026.ABSTRACT Problem Tokishakuyakusan (TSS) is a traditional Japanese Kampo medicine widely used to support pregnancy; however, its molecular mechanisms remain poorly understood. This study aimed to elucidate the progesterone‐related immunomodulatory mechanisms underlying the pregnancy‐supportive effects of TSS using a mouse model of progesterone ...
Takeshi Nagamatsu +8 more
wiley +1 more source
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers.
Pui Yeng Lam +2 more
doaj +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, Volume 81, Issue 9, Page 3236-3249, September 2026.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
European Journal of Immunology, Volume 56, Issue 8, August 2026.Human thymopoiesis undergoes a dynamic postnatal transition, revealing maximal intrathymic sjTREC production at birth, shifts in thymocyte phenotype and composition, and a transient wave of effector Vδ2+ γδ T cells during early infancy. ABSTRACT The thymus generates a diverse and self‐tolerant T‐cell repertoire.
Camille Kergaravat +10 more
wiley +1 more source
Immunometabolic Activation of Invariant Natural Killer T Cells
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +1 more source