Results 21 to 30 of about 8,233 (133)

The response of CD1d-restricted invariant NKT cells to microbial pathogens and their products

Frontiers in Immunology, 2015
Invariant natural killer T (iNKT) cells become activated during a wide variety of infections. This includes organisms lacking cognate CD1d-binding glycolipid antigens recognized by the semi-invariant T cell receptor of iNKT cells. Additional studies have
Luc eVan Kaer, Vrajesh eParekh, Lan eWu
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Invariant natural killer T cells minimally influence gut microbiota composition in mice

Gut Microbes, 2022
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey   +10 more
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Regulated expression of miR-155 is required for iNKT cell development

Frontiers in Immunology, 2015
Invariant Natural Killer T cells (iNKT cells) are CD1d-restricted, lipid antigen–reactive T lymphocytes with immunoregulatory functions. iNKT cell development in the thymus proceeds through subsequent stages, defined by the expression of CD44 and NK1.1 ...
Alessia eBurocchi, Paola ePittoni, Esmerina eTili, Esmerina eTili, Alice eRigoni, Stefan eCostinean, Carlo Maria Croce, MARIO Paolo COLOMBO   +7 more
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Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation

Cell Reports, 2019
Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park, Devon T. DiPalma, Juntae Kwon, Juliet Fink, Jung-Hyun Park   +4 more
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Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC

Frontiers in Immunology, 2021
Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance ...
Ching-Lien Wu, Ching-Lien Wu, Ching-Lien Wu, Julien Caumartin, Giada Amodio, François Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult, Joel LeMaoult   +10 more
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Porcine Invariant Natural Killer T Cells: Functional Profiling and Dynamics in Steady State and Viral Infections

Frontiers in Immunology, 2019
Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model ...
Alexander Schäfer, Jane Hühr, Theresa Schwaiger, Anca Dorhoi, Thomas C. Mettenleiter, Sandra Blome, Charlotte Schröder, Ulrike Blohm   +7 more
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Identification of distinct human invariant natural killer T-cell response phenotypes to alpha-galactosylceramide

BMC Immunology, 2008
Background Human CD1d-restricted, invariant natural killer T cells (iNKT) are a unique class of T lymphocytes that recognise glycolipid antigens such as α-galactosylceramide (αGalCer) and upon T cell receptor (TCR) activation produce both Th1 and Th2 ...
Besra Gurdyal S, Illarionov Petr A, Willcox Carrie R, Mura Manuela, Curbishley Stuart M, Croudace Joanne E, Adams David H, Lammas David A   +7 more
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Comparative assessment of autologous and allogeneic iNKT cell transfer in iNKT cell-based immunotherapy

Frontiers in Immunology
Invariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
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Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

eLife, 2022
Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch   +9 more
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Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets

Frontiers in Immunology, 2020
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes. They quickly respond to antigenic stimulation by producing copious amounts of cytokines and chemokines.
Nathan G. F. Leborgne, Nathan G. F. Leborgne, Nathan G. F. Leborgne, Adriano Taddeo, Adriano Taddeo, Stefan Freigang, Charaf Benarafa, Charaf Benarafa   +7 more
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