Results 21 to 30 of about 16,069 (248)

Thymic iNKT cell differentiation at single-cell resolution. [PDF]

Cell Mol Immunol, 2021
Wang K, Zhao W, Jin R, Ge Q.
europepmc   +3 more sources

Challenges of iNKT cell-based antitumor immunotherapies. [PDF]

Cell Mol Immunol, 2021
Zhang H, Bai L.
europepmc   +3 more sources

Kidins220 and Aiolos promote thymic iNKT cell development by reducing TCR signals [PDF]

Sci Adv
Laurenz A. Herr, Gina J. Fiala, Sagar, Anna-Maria Schaffer, Jonas F. Hummel, Marina Zintchenko, Katrin Raute, Rubí M.-H. Velasco Cárdenas, Beate Heizmann, Karolina Ebert, Kerstin Fehrenbach, Iga Janowska, Susan Chan, Yakup Tanriver, Susana Minguet, Wolfgang W. Schamel   +15 more
openalex   +2 more sources

INKT CELLS IN DISLIPIDEMIA.

, 2014
Natural killer T cells (NKT) are T lymphocytes with a reactivity directed against glycolipid antigens presented by MHC-like CD1d molecules expressed by antigen presenting cells (APC). A large proportion of these cells (invariant NKT cells (iNKT)) possess strong immunomodulatory properties which impose a profound impact on the development and course of ...
Sergey N. Bondarenko
openalex   +3 more sources

Engineered Stem Cells Provide Cancer-Killing iNKT Cells [PDF]

Cell Stem Cell, 2019
Invariant natural killer T (iNKT) cells have been tested for their potential use in cancer immune therapy, but their low frequency has limited their use. In this issue, Zhu and colleagues propose to overcome this by engineering hematopoietic stem cells (HSCs) to provide a continual source of iNKT cells. (Zhu et al., 2019).
M. Murray, Mitchell Kronenberg
openalex   +4 more sources

CD8+ T-cell immunity orchestrated by iNKT cells

Frontiers in Immunology, 2023
CD8+ T cells belonging to the adaptive immune system play key roles in defending against viral infections and cancers. The current CD8+ T cell-based immunotherapy has emerged as a superior therapeutic avenue for the eradication of tumor cells and long-term prevention of their recurrence in hematologic malignancies.
Yingyu Qin, Xueyang Bao, Mingzhu Zheng
openaire   +3 more sources

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Cell Discovery, 2022
Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi   +9 more
doaj   +1 more source

TET proteins regulate T cell and iNKT cell lineage specification in a TET2 catalytic dependent manner [PDF]

Front Immunol, 2022
Tarmo Äijö, Dimitris Theofilatos, Meng Cheng, Matthew D. Smith, Yue Xiong, Albert S. Baldwin, Ageliki Tsagaratou   +6 more
openalex   +2 more sources

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Stem Cell Research & Therapy, 2022
Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang   +11 more
doaj   +1 more source