Results 21 to 30 of about 8,083 (126)
eLife, 2022 Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane +9 more
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Aberrant Presentation of Self-Lipids by Autoimmune B Cells Depletes Peripheral iNKT Cells
Cell Reports, 2014 Summary: Invariant natural killer T (iNKT) cells provide cognate help via CD1d to lipid antigen-presenting B cells for antibody production, but whether B cells reciprocally regulate iNKT cells remains largely unexplored.
Andy Hee-Meng Tan +5 more
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Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo. [PDF]
PLoS ONE, 2015 Invariant Natural Killer T (iNKT) cells are a T cell subset expressing an invariant T Cell Receptor (TCR) that recognizes glycolipid antigens rather than peptides.
Felix Scheuplein +7 more
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Invariant natural killer T cells minimally influence gut microbiota composition in mice
Gut Microbes, 2022 Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin +10 more
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Molecular Oncology, 2021 Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor immunity.
Angélica Díaz‐Basabe +7 more
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Frontiers in Immunology, 2019 The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao +8 more
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Frontiers in Cell and Developmental Biology, 2021 The development of invariant natural killer T (iNKT) cells requires a well-attuned set of transcription factors, but how these factors are regulated and coordinated remains poorly understood. MicroRNA-155 (miR-155) is a key regulator of numerous cellular
Jie Wang +16 more
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A humanized mouse model for in vivo evaluation of invariant Natural Killer T cell responses
Frontiers in Immunology, 2022 Invariant natural killer T (iNKT) cells mediate immune responses when stimulated by glycolipid agonists presented by CD1d. In extensive studies of synthetic analogues of α-galactosyl ceramides, we identified numerous examples of significant differences ...
Noemi Alejandra Saavedra-Avila +7 more
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Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers.
Pui Yeng Lam +2 more
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The Transcriptional Repressor Gfi1 Plays a Critical Role in the Development of NKT1- and NKT2-Type iNKT Cells. [PDF]
PLoS ONE, 2016 Gfi1 plays an important role in the development and maintenance of many hematopoietic linage cells. However, the impact of Gfi1-deficiency on the iNKT cell differentiation remains unclear.
Toshiaki Yasuoka +7 more
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