Results 21 to 30 of about 9,712 (187)

Targeting iNKT cells for the treatment of sickle cell disease [PDF]

Clinical Immunology, 2011
Sickle cell disease (SCD) causes widely disseminated vaso-occlusive episodes. Building on evidence implicating invariant NKT (iNKT) cells in the pathogenesis of ischemia/reperfusion injury, recent studies demonstrate that blockade of iNKT cell activation in mice with SCD reduces pulmonary inflammation and injury.
Joshua J Field, Joel Linden
exaly   +3 more sources

Mouse Invariant Monoclonal Antibody NKT14: A Novel Tool to Manipulate iNKT Cell Function In Vivo. [PDF]

PLoS ONE, 2015
Invariant Natural Killer T (iNKT) cells are a T cell subset expressing an invariant T Cell Receptor (TCR) that recognizes glycolipid antigens rather than peptides.
Felix Scheuplein, Deanna J Lamont, Matthew E Poynter, Jonathan E Boyson, David Serreze, Lennart K A Lundblad, Robert Mashal, Robert Schaub   +7 more
doaj   +2 more sources

Eed-dependent histone modification orchestrates the iNKT cell developmental program alleviating liver injury [PDF]

Frontiers in Immunology
Polycomb repressive complex 2 (PRC2) is an evolutionarily conserved epigenetic modifier responsible for tri-methylation of lysine 27 on histone H3 (H3K27me3).
Yun Guo, Shun Ohki, Yohei Kawano, Weng Sheng Kong, Yoshinori Ohno, Hiroaki Honda, Masamoto Kanno, Masamoto Kanno, Masamoto Kanno, Tomoharu Yasuda   +9 more
doaj   +2 more sources

ScRNA-Seq Analyses Define the Role of GATA3 in iNKT Cell Effector Lineage Differentiation [PDF]

Cells
While the transcription factor GATA-3 is well-established for its crucial role in T cell development, its specific influence on invariant natural killer T (iNKT) cells remains relatively unexplored.
Tzong-Shyuan Tai, Huang-Yu Yang, Wan-Chu Chuang, Yu-Wen Huang, I-Cheng Ho, Ching-Chung Tsai, Ya-Ting Chuang   +6 more
doaj   +2 more sources

Melanoma Cells Inhibit iNKT Cell Functions via PGE2 and IDO1. [PDF]

Cancers (Basel), 2023
Simple Summary The unique properties of invariant natural killer T (iNKT) cells make them an attractive candidate for cancer-adoptive immunotherapy. However, despite their potential, clinical studies have not consistently shown successful outcomes.
Torre E, Pinton G, Lombardi G, Fallarini S.   +3 more
europepmc   +3 more sources

Clinical Application of iNKT Cell-mediated Anti-tumor Activity Against Lung Cancer and Head and Neck Cancer

Frontiers in Immunology, 2018
Invariant natural killer T (iNKT) cells produce copious amounts of cytokines in response to T-cell receptor (TCR) stimulation by recognizing antigens such as α-galactosylceramide (α-GalCer) presented on CD1d; thus, orchestrating other immune cells to ...
Mariko Takami, Fumie Ihara, Fumie Ihara, Shinichiro Motohashi   +3 more
doaj   +3 more sources

SLAM-ing the brakes on iNKT cell selection. [PDF]

Nat Immunol, 2019
Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity of SAP–Fyn and SHP-1, respectively.
Iyer SS, Huang YH, Blumberg RS.
europepmc   +4 more sources

Thymic iNKT cell differentiation at single-cell resolution. [PDF]

Cell Mol Immunol, 2021
Wang K, Zhao W, Jin R, Ge Q.
europepmc   +3 more sources

Challenges of iNKT cell-based antitumor immunotherapies. [PDF]

Cell Mol Immunol, 2021
Zhang H, Bai L.
europepmc   +3 more sources

Distinct iNKT Cell Populations Use IFNγ or ER Stress-Induced IL-10 to Control Adipose Tissue Homeostasis. [PDF]

Cell Metab, 2020
LaMarche NM, Kane H, Kohlgruber AC, Dong H, Lynch L, Brenner MB.   +5 more
europepmc   +2 more sources