Results 31 to 40 of about 10,168 (211)

The Role of Autophagy in iNKT Cell Development [PDF]

Frontiers in Immunology, 2018
CD1d-restricted invariant natural killer T (iNKT) cells are innate-like T cells that express an invariant T cell receptor (TCR) α-chain and recognize self and foreign glycolipid antigens. They can rapidly respond to agonist activation and stimulate an extensive array of immune responses.
Guan Yang, John P. Driver, Luc Van Kaer
openaire   +3 more sources

Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]

PLoS ONE, 2012
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li, Patricia Polacino, Raquel Garcia-Navarro, Shiu-Lok Hu, Moriya Tsuji   +4 more
doaj   +1 more source

Novel Approaches to Exploiting Invariant NKT Cells in Cancer Immunotherapy

Frontiers in Immunology, 2018
iNKT cells are a subset of innate-like T cells that utilize an invariant TCR alpha chain complexed with a limited repertoire of TCR beta chains to recognize specific lipid antigens presented by CD1d molecules.
Benjamin J. Wolf, Jiyoung Elizabeth Choi, Jiyoung Elizabeth Choi, Mark A. Exley, Mark A. Exley, Mark A. Exley   +5 more
doaj   +1 more source

Development of off-the-shelf hematopoietic stem cell-engineered invariant natural killer T cells for COVID-19 therapeutic intervention

Stem Cell Research & Therapy, 2022
Background New COVID-19 treatments are desperately needed as case numbers continue to rise and emergent strains threaten vaccine efficacy. Cell therapy has revolutionized cancer treatment and holds much promise in combatting infectious disease, including
Yan-Ruide Li, Zachary Spencer Dunn, Gustavo Garcia, Camille Carmona, Yang Zhou, Derek Lee, Jiaji Yu, Jie Huang, Jocelyn T. Kim, Vaithilingaraja Arumugaswami, Pin Wang, Lili Yang   +11 more
doaj   +1 more source

The iNKT Cell–Macrophage Axis in Homeostasis and Disease [PDF]

International Journal of Molecular Sciences, 2022
Invariant natural killer T (iNKT) cells are CD1d-restricted, lipid-reactive T cells that exhibit preponderant immunomodulatory properties. The ultimate protective or deleterious functions displayed by iNKT cells in tissues are known to be partially shaped by the interactions they establish with other immune cells.
Mariana S. Cruz, José Pedro Loureiro, Maria J. Oliveira, Maria Fatima Macedo   +3 more
openaire   +2 more sources

Invariant natural killer T cells minimally influence gut microbiota composition in mice

Gut Microbes, 2022
Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin, Meggie Kuypers, Zhewei Liu, Julia K Copeland, Donny Chan, Susan J Robertson, Jean Kontogiannis, David S Guttman, E. Kate Banks, Dana J Philpott, Thierry Mallevaey   +10 more
doaj   +1 more source

Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor

Frontiers in Immunology, 2019
The invariant NKT (iNKT) cells recognize glycolipid antigens presented by the non-classical MHC like molecule CD1d. They represent an innate T-cell lineage with the ability to rapidly produce a variety of cytokines in response to agonist stimulation to ...
Huishan Tao, Huishan Tao, Lei Li, Lei Li, Ying Gao, Zehua Wang, Xiao-Ping Zhong, Xiao-Ping Zhong, Xiao-Ping Zhong   +8 more
doaj   +1 more source

De novo fatty-acid synthesis protects invariant NKT cells from cell death, thereby promoting their homeostasis and pathogenic roles in airway hyperresponsiveness

eLife, 2023
Invariant natural-killer T (iNKT) cells play pathogenic roles in allergic asthma in murine models and possibly also humans. While many studies show that the development and functions of innate and adaptive immune cells depend on their metabolic state ...
Jaemoon Koh, Yeon Duk Woo, Hyun Jung Yoo, Jun-Pyo Choi, Sae Hoon Kim, Yoon-Seok Chang, Kyeong Cheon Jung, Ji Hyung Kim, Yoon Kyung Jeon, Hye Young Kim, Doo Hyun Chung   +10 more
doaj   +1 more source

Thymic stromal lymphopoietin production in DN32.D3 invariant natural killer T (iNKT) cell line and primary mouse liver iNKT cells

, 2021
Background: invariant natural killer T (iNKT) cells are known as the fast responder in allergic inflammation and the source of interleukin (IL)-4, IL-13, and interferon-gamma.
Choi, Jun-Pyo, Losol, Purevsuren, Chang, Yoon-Seok, Woo, Yeon Duk, Kim, Sae-Hoon   +4 more
core   +1 more source

Synthesis of Cyclopropene‐Modified Fatty Acids Allows Single‐Cell Quantification of Uptake by Immune Cells

Angewandte Chemie, EarlyView.
Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda, Graham A. Heieis, Laura Bogue Edgerton, Kristine Bertheussen, Diana Torres‐García, Marouane el Boujadayni, Kas Steuten, Jeroen M. Punt, Wouter P. F. Driever, Connor Corrigan, Xinyuan Wang, Bart Everts, David Finlay, Mario van der Stelt, Sander I. van Kasteren   +14 more
wiley   +2 more sources