Results 31 to 40 of about 8,218 (178)
Cell Discovery, 2022 Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang +9 more
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Invariant natural killer T cells minimally influence gut microbiota composition in mice
Gut Microbes, 2022 Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin +10 more
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Cell Reports, 2019 Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park +4 more
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Frontiers in Immunology, 2022 Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by heterogeneous inflammatory endotypes of unknown etiology. Invariant natural killer T (iNKT) cells are multifunctional innate T cells that exhibit Th1-, Th2-, and Th17-like ...
Xiaoyan Ye +14 more
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Immunoregulation by iNKT Cells
YAKUGAKU ZASSHI, 2009 NKT cells are defined as cells co-expressing of the natural killer receptors such as NK1.1 or NKR-P1A (CD161) and a T cell receptor (TCR). Although NK1.1(+) TCR(+) lymphocytes are heterogeneous, we focus on two distinct T cell subsets express invariant T cell receptor alpha chains, Valpha14-Jalpha18(Valpha14i) and Valpha19-Jalpha33(Valpha19i ...
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Generation of Mouse iNKT Cell Lines
BIO-PROTOCOL, 2013 Natural killer T (NKT) cells bridge the innate and adaptive arms of the immune system, and manipulating their effector functions can have therapeutic significances in the treatment of autoimmunity, transplant biology, infectious disease and cancer. This important lymphocyte subset regulates the immune system through their potent cytokine production ...
Xiangming Li +3 more
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Targeting iNKT cells for the treatment of sickle cell disease [PDF]
Clinical Immunology, 2011 Sickle cell disease (SCD) causes widely disseminated vaso-occlusive episodes. Building on evidence implicating invariant NKT (iNKT) cells in the pathogenesis of ischemia/reperfusion injury, recent studies demonstrate that blockade of iNKT cell activation in mice with SCD reduces pulmonary inflammation and injury.
Joshua J, Field +2 more
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Harnessing invariant natural killer T cells to control pathological inflammation
Frontiers in Immunology, 2022 Invariant natural killer T (iNKT) cells are innate T cells that are recognized for their potent immune modulatory functions. Over the last three decades, research in murine models and human observational studies have revealed that iNKT cells can act to ...
Nikhila S. Bharadwaj, Jenny E. Gumperz
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Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
JCI Insight, 2022 Invariant NK T (iNKT) cells are implicated in viral clearance; however, their role in hepatitis C virus (HCV) infection remains controversial. Here, iNKT cells were studied during different stages of HCV infection. iNKT cells from patients with acute HCV
Tina Senff +11 more
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Towards a better understanding of human iNKT cell subpopulations for improved clinical outcomes
Frontiers in Immunology, 2023 Invariant natural killer T (iNKT) cells are a unique T lymphocyte population expressing semi-invariant T cell receptors (TCRs) that recognise lipid antigens presented by CD1d.
Alex Look +7 more
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