Results 51 to 60 of about 15,268 (219)

Invariant NKT cells: regulation and function during viral infection.

PLoS Pathogens, 2012
Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), express a highly restricted T cell receptor (TCR) and respond to CD1d ...
Jennifer A Juno, Yoav Keynan, Keith R Fowke   +2 more
doaj   +1 more source

Generation of Mouse iNKT Cell Lines

BIO-PROTOCOL, 2013
Natural killer T (NKT) cells bridge the innate and adaptive arms of the immune system, and manipulating their effector functions can have therapeutic significances in the treatment of autoimmunity, transplant biology, infectious disease and cancer. This important lymphocyte subset regulates the immune system through their potent cytokine production ...
Xiangming Li, Moriya Tsuji, Jonathan Schneck, Tonya Webb   +3 more
openaire   +3 more sources

The histone demethylase UTX regulates the lineage-specific epigenetic program of invariant natural killer T cells [PDF]

, 2018
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development.
Barnitz, R Anthony, Beyaz, Semir, Das, Partha P, Dogum, Rizkullah, Haining, W Nicholas, Herault, Aurelie, Hu, Yu,M.C.P.Massachusetts Institute of Technology., Huang, Jialiang, Kerenyi, Marc A, Kim, Ji Hyung, Orkin, Stuart H, Passegue, Emmanuelle, Pinello, Luca, Winau, Florian, Xifaras, Michael, Yilmaz, Omer, Yuan, Guo-Cheng   +16 more
core   +1 more source

Untangling iNKT Cell Function in Adipose Tissue Homeostasis [PDF]

Cell Metabolism, 2020
iNKT cells are important regulatory cells in metabolic health and disease. In this issue of Cell Metabolism, LaMarche et al. (2020) clarify the origin and heterogeneity of these unconventional T cells and identify the specific signals in adipose tissues that direct their function.
Ruth A, Franklin, Ruslan, Medzhitov
openaire   +2 more sources

iNKT Cells and Their Potential Lipid Ligands during Viral Infection [PDF]

, 2015
Invariant natural killer T (iNKT) cells are a unique population of lipid-reactive CD1d-restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Anunya Opasawatchai, Ponpan Matangkasombut   +1 more
core   +1 more source

Quantitative Difference in PLZF Protein Expression Determines iNKT Lineage Fate and Controls Innate CD8 T Cell Generation

Cell Reports, 2019
Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park, Devon T. DiPalma, Juntae Kwon, Juliet Fink, Jung-Hyun Park   +4 more
doaj   +1 more source

Single-cell analysis reveals differences among iNKT cells colonizing peripheral organs and identifies Klf2 as a key gene for iNKT emigration

Cell Discovery, 2022
Invariant natural killer T cell (iNKT) subsets are differentially distributed in various immune organs. However, it remains unclear whether iNKT cells exhibit phenotypical and functional differences in different peripheral organs and how thymic iNKT ...
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi   +9 more
doaj   +1 more source

Type 2 and Type 17 Invariant Natural Killer T Cells Contribute to Local Eosinophilic and Neutrophilic Inflammation and Their Function Is Regulated by Mucosal Microenvironment in Nasal Polyps

Frontiers in Immunology, 2022
Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by heterogeneous inflammatory endotypes of unknown etiology. Invariant natural killer T (iNKT) cells are multifunctional innate T cells that exhibit Th1-, Th2-, and Th17-like ...
Xiaoyan Ye, Qing Bao, Qing Bao, Hexin Chen, Qingxiang Meng, Qianying Li, Lin Sun, Jian Li, Wenbin Lei, Weiping Wen, Wenjing He, Linyi Jiao, Bixing Fang, Yifang Gao, Chunwei Li   +14 more
doaj   +1 more source

T cells, the next big target in axSpA?

Arthritis &Rheumatology, Accepted Article.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells.
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources