Results 51 to 60 of about 10,168 (211)
Evaluation of iNKT cells in patients with endometriosis
, 2018 Introdução: A endometriose é uma doença com características inflamatórias que atinge as mulheres em idade reprodutiva. A patogênese da endometriose não está esclarecida.
Correa, Frederico José Silva
core +1 more source
iNKT cells possess and mobilize pCD40L.
, 2012 A, A fraction of the DN thymocyte population mobilizes pCD40L upon stimulation with PMA plus ionomycin. B, pCD40L positive DN thymocytes are iNKT cells. C, iNKT deficient β2m−/− mice lack the pCD40L positive DN thymocyte population.
David B. Jacoby (182049) +7 more
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Peripheral blood iNKT cell activation correlates with liver damage during acute hepatitis C
JCI Insight, 2022 Invariant NK T (iNKT) cells are implicated in viral clearance; however, their role in hepatitis C virus (HCV) infection remains controversial. Here, iNKT cells were studied during different stages of HCV infection. iNKT cells from patients with acute HCV
Tina Senff +11 more
doaj +1 more source
Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. [PDF]
PLoS ONE, 2013 Invariant natural killer T (iNKT) cells play important roles in bridging innate and adaptive immunity via rapidly producing a variety of cytokines. A small subset of iNKT cells produces IL-17 and is generated in the thymus during iNKT-cell ontogeny.
Jinhong Wu +4 more
doaj +1 more source
Invariant NKT cells: regulation and function during viral infection.
PLoS Pathogens, 2012 Natural killer T cells (NKT cells) represent a subset of T lymphocytes that express natural killer (NK) cell surface markers. A subset of NKT cells, termed invariant NKT cells (iNKT), express a highly restricted T cell receptor (TCR) and respond to CD1d ...
Jennifer A Juno +2 more
doaj +1 more source
Using agonists for iNKT cells in cancer therapy
Molecular Immunology, 2021 The capacity of α-galactosylceramide (α-GalCer) to act as an anti-cancer agent in mice through the specific stimulation of type I NKT (iNKT) cells has prompted extensive investigation to translate this finding to the clinic. However, low frequencies of iNKT cells in cancer patients and their hypo-responsiveness to repeated stimulation have been seen as
Gavin F. Painter +2 more
openaire +2 more sources
Cell Reports, 2019 Summary: Zbtb16 encodes the zinc-finger protein PLZF, which is often used as a lineage marker for innate-like T cells and is specifically required for the generation of invariant natural killer T (iNKT) cells in the thymus.
Joo-Young Park +4 more
doaj +1 more source
Harnessing invariant natural killer T cells to control pathological inflammation
Frontiers in Immunology, 2022 Invariant natural killer T (iNKT) cells are innate T cells that are recognized for their potent immune modulatory functions. Over the last three decades, research in murine models and human observational studies have revealed that iNKT cells can act to ...
Nikhila S. Bharadwaj, Jenny E. Gumperz
doaj +1 more source
Arthritis &Rheumatology, EarlyView.Objective We aimed to characterize CD4+ T cell plasticity in human systemic lupus erythematosus (SLE) by leveraging T cell receptor (TCR) repertoire features as markers of prior lineage states, integrating TCR and transcriptomic profiling to delineate plasticity patterns and evaluate their association with clinical disease activity. Methods We used TCR
Yasuo Nagafuchi +11 more
wiley +1 more source
Induction of antiinflammatory purinergic signaling in activated human iNKT cells. [PDF]
, 2018 Invariant natural killer T (iNKT) cells are activated at sites of local tissue injury, or globally during vaso-occlusive episodes of sickle cell disease (SCD). Tissue damage stimulates production of CD1d-restricted lipid antigens that activate iNKT cells
Field, Joshua +3 more
core +1 more source