Results 61 to 70 of about 10,168 (211)

Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States

Frontiers in Immunology, 2021
Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for activation and possess innate NK-like functional features. Currently, iNKT cell-based immunotherapies remain in early clinical stages, and little is known
Priya Khurana, Priya Khurana, Chakkapong Burudpakdee, Stephan A. Grupp, Stephan A. Grupp, Ulf H. Beier, Ulf H. Beier, Ulf H. Beier, David M. Barrett, Hamid Bassiri, Hamid Bassiri   +10 more
doaj   +1 more source

T cells, the Next Big Target in Axial Spondyloarthritis?

Arthritis &Rheumatology, EarlyView.
Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley   +1 more source

iNKT cells are reduced in CVID.

, 2013
(A) Representative staining illustrating the gating strategy used. (B) Comparison between the frequency of iNKT cells in healthy control subjects and CVID patients before IVIg (left panel), and in CVID patients before and after IVIg (right panel).
Jorge Kalil (52916), Markus Moll (109640), Cristina M. Kokron (468576), Dominic Paquin-Proulx (468572), Bianca A. N. Santos (468573), Karina I. Carvalho (244966), Ana Karolina Barreto de Oliveira (468575), Johan K. Sandberg (353026), Myrthes Toledo-Barros (468574), Esper G. Kallas (36139)   +9 more
core   +1 more source

Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients

Frontiers in Cell and Developmental Biology, 2022
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T ...
Yifan Hu, Yifan Hu, Yifan Hu, Youdong Chen, Youdong Chen, Zeyu Chen, Zeyu Chen, Xilin Zhang, Xilin Zhang, ChunYuan Guo, ChunYuan Guo, ZengYang Yu, ZengYang Yu, Peng Xu, Peng Xu, Lei Sun, Lei Sun, Xue Zhou, Xue Zhou, Yu Gong, Yu Gong, Qian Yu, Qian Yu, Yuling Shi, Yuling Shi, Yuling Shi   +25 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Differential Activation of Unconventional T Cells, Including iNKT Cells, in Alcohol‐Related Liver Disease [PDF]

, 2020
BACKGROUND: Liver is enriched in several innate-like unconventional T cells, but their role in alcohol-related liver disease (ALD) is not fully understood. Studies in several acute alcohol feeding models but not in chronic alcoholic steatohepatitis (ASH)
Maricic, Igor, Vipin Kumar, Timothy R. Morgan, Liu, Zhang‐Xu, Zhang‐Xu Liu, Marrero, Idania, Igor Maricic, Schnabl, Bernd, Hidekazu Tsukamoto, Idania Marrero, Andrew A. Stolz, Tsukamoto, Hidekazu, Morgan, Timothy R, Bernd Schnabl, Stolz, Andrew A, Kumar, Vipin   +15 more
core   +1 more source

iNKT Cells Suppress Pathogenic NK1.1+CD8+ T Cells in DSS-Induced Colitis [PDF]

, 2018
T cells producing IFNγ play a pathogenic role in the development of inflammatory bowel disease (IBD). To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated ...
천재희
core   +2 more sources

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

TCR-engineered iNKT cells induce robust antitumor response by dual targeting cancer and suppressive myeloid cells

, 2022
Adoptive immunotherapy with T cells engineered with tumor-specific T cell receptors (TCRs) holds promise for cancer treatment. However, suppressive cues generated in the tumor microenvironment (TME) can hinder the efficacy of these therapies, prompting ...
Perini, Alessandra, Garavaglia, Claudio, Consonni, Michela, de Lalla, Claudia, Fedeli, Maya, Antonini, Gaia, Squadrito, Mario L., Azzimonti, Laura, Re, Francesca, Shen, Haifa, Dellabona, Paolo, Sesana, Silvia, Casorati, Giulia, Delfanti, Gloria, Cortesi, Filippo   +14 more
core   +1 more source