Results 71 to 80 of about 10,168 (211)
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
eLife, 2019 Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells.
Rebeca Jimeno +10 more
doaj +1 more source
Homeostatic regulation of marginal zone B cells by invariant natural killer T cells. [PDF]
PLoS ONE, 2011 Marginal zone B cells (MZB) mount a rapid antibody response, potently activate naïve T cells, and are enriched in autoreactive B cells. MZBs express high levels of CD1d, the restriction element for invariant natural killer T cells (iNKT).
Xiangshu Wen +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance ...
Ching-Lien Wu +10 more
doaj +1 more source
MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation
Allergy, EarlyView.In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata +6 more
wiley +1 more source
iNKT cells at the interface between innate and adaptive immunity.
, 2013 iNKT cells recognize lipids presented by CD1d molecules. Upon activation, iNKT cells modulate the function of CD1d-expressing cells, such as APCs and B cells.
Mariolina Salio (70402) +1 more
core +1 more source
Traversing the bench to bedside journey for iNKT cell therapies
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are immune cells that harness properties of both the innate and adaptive immune system and exert multiple functions critical for the control of various diseases.
Julie O’Neal +6 more
doaj +1 more source
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers.
Pui Yeng Lam +2 more
doaj +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source
Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury
Cell Reports, 2023 Summary: Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d.
Cristhiane Favero Aguiar +20 more
doaj +1 more source
Professional Differences in Antigen Presentation to iNKT Cells [PDF]
Immunity, 2014 Invariant natural killer T cells are preactivated lymphocytes that react upon recognition of CD1d-antigen complexes. Accordingly, any type of CD1d-positive cell could behave as antigen-presenting cell (APC). In this issue of Immunity, Arora et al. (2014), report that professional APCs still make the difference.
De Libero, Gennaro, Mori, Lucia
openaire +4 more sources