Results 71 to 80 of about 15,268 (219)

Tissue-specific metabolic profile drives iNKT cell function during obesity and liver injury

Cell Reports, 2023
Summary: Invariant natural killer T (iNKT) cells are a distinct population of lymphocytes characterized by their reactivity to glycolipids presented by CD1d.
Cristhiane Favero Aguiar, Felipe Corrêa-da-Silva, Michelangelo Bauwelz Gonzatti, Monara Kaelle Angelim, Marco Antonio Pretti, Gustavo Gastão Davanzo, Bianca Gazieri Castelucci, Lauar Brito Monteiro, Gisele Castro, João Victor Virgilio-da-Silva, Guilherme Ribeiro, Vitor Jaccomo, Mirella C. Pereira Andrade, Webster Leonardo Costa, Victor Gambarini, Fernanda Fernandes Terra, José Carlos Alves-Filho, Niels Olsen Saraiva Câmara, Mariana Boroni, Alexandre Castro Keller, Pedro M. Moraes-Vieira   +20 more
doaj   +1 more source

Activation of iNKT Cells Prevents Salmonella-Enterocolitis and Salmonella-Induced Reactive Arthritis by Downregulating IL-17-Producing γδT Cells [PDF]

, 2017
Reactive arthritis (ReA) is an inflammatory condition of the joints that arises following an infection. Salmonella enterocolitis is one of the most common infections leading to ReA.
Aya Castañeda, Maria del Rosario, Blanco, Guillermo Armando C., Cerquetti, Maria Cristina, Giacomodonato, Mónica Nancy, Morales, Andrea Lorena, Noto Llana, Mariangeles, Sarnacki, Sebastian Hernan   +6 more
core   +1 more source

Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy

MedComm, Volume 7, Issue 5, May 2026.
Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley   +1 more source

Distinct Bioenergetic Features of Human Invariant Natural Killer T Cells Enable Retained Functions in Nutrient-Deprived States

Frontiers in Immunology, 2021
Invariant natural killer T (iNKT) cells comprise a unique subset of lymphocytes that are primed for activation and possess innate NK-like functional features. Currently, iNKT cell-based immunotherapies remain in early clinical stages, and little is known
Priya Khurana, Priya Khurana, Chakkapong Burudpakdee, Stephan A. Grupp, Stephan A. Grupp, Ulf H. Beier, Ulf H. Beier, Ulf H. Beier, David M. Barrett, Hamid Bassiri, Hamid Bassiri   +10 more
doaj   +1 more source

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia [PDF]

, 2014
SignificanceInvariant natural killer T cells (iNKT) have been found primarily patrolling inside blood vessels in the liver, where they respond to bacterial glycolipids presented by CD1d on liver macrophages. We show joint iNKT cells are localized outside
A. Marques, A. Salman-Dilgimen, Ajuebor, Auffray, Baba, Barbour, Bendelac, C. H. Mody, C. H. Y. Wong, Faunce, G. Chaconas, Geissmann, Hickey, Katagiri, Kawabata, Kawano, Kobayashi, Kronenberg, Kuylenstierna, Lee, M.-J. Sanz, Ma, Mattner, Moriarty, Norman, Oosting, P. Kubes, P.-O. Hardy, R. Krawetz, Steere, STEERE, T. J. Moriarty, van Gisbergen, W.-Y. Lee   +33 more
core   +1 more source

Human Cytomegalovirus Infection in Haematopoietic Stem Cell Transplant Recipients and CAR T Cell Recipients – PART 1: Risk Factors, Clinical Impact and Immune Response

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan, Emily Blyth, Gaurav Sutrave, Michelle K. Yong, David J. Gottlieb, Allison Abendroth, Barry Slobedman, Lauren Stern   +7 more
wiley   +1 more source

iNKT cells ameliorate human autoimmunity: Lessons from alopecia areata

Journal of Autoimmunity, 2018
Alopecia areata (AA) is understood to be a CD8+/NKG2D+ T cell-dependent autoimmune disease. Here, we demonstrate that human AA pathogenesis of is also affected by iNKT10 cells, an unconventional T cell subtype whose number is significantly increased in AA compared to healthy human skin.
Amal Ghraieb, Aviad Keren, Alex Ginzburg, Yehuda Ullmann, Adam G. Schrum, Ralf Paus, Amos Gilhar   +6 more
openaire   +4 more sources

Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients

Frontiers in Cell and Developmental Biology, 2022
Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T ...
Yifan Hu, Yifan Hu, Yifan Hu, Youdong Chen, Youdong Chen, Zeyu Chen, Zeyu Chen, Xilin Zhang, Xilin Zhang, ChunYuan Guo, ChunYuan Guo, ZengYang Yu, ZengYang Yu, Peng Xu, Peng Xu, Lei Sun, Lei Sun, Xue Zhou, Xue Zhou, Yu Gong, Yu Gong, Qian Yu, Qian Yu, Yuling Shi, Yuling Shi, Yuling Shi   +25 more
doaj   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors.

PLoS ONE, 2013
Reperfusion injury following tissue ischemia occurs as a consequence of vaso-occlusion that is initiated by activation of invariant natural killer T (iNKT) cells.
Gene Lin, Joshua J Field, Jennifer C Yu, Ruey Ken, Donna Neuberg, David G Nathan, Joel Linden   +6 more
doaj   +1 more source