Results 71 to 80 of about 8,218 (178)

Professional Differences in Antigen Presentation to iNKT Cells [PDF]

Immunity, 2014
Invariant natural killer T cells are preactivated lymphocytes that react upon recognition of CD1d-antigen complexes. Accordingly, any type of CD1d-positive cell could behave as antigen-presenting cell (APC). In this issue of Immunity, Arora et al. (2014), report that professional APCs still make the difference.
De Libero, Gennaro, Mori, Lucia
openaire   +4 more sources

MAIT Cells Suppress IgE‐Mediated Asthma via IFNγ‐Dependent B Cell Regulation

Allergy, Volume 81, Issue 9, Page 3236-3249, September 2026.
In this study, we demonstrate that MAIT cell antagonism during sensitization and challenge with HDM worsens the development of airway hyperreactivity without effects on type 2 or 17 associated cytokine production or lung inflammation. Rather, MAIT cells appear to regulate HDM‐induced asthma through direct inhibition of IgE production.
Angela M. Cannata, Jaclyn W. McAlees, Julie M. Hargis, Archana Shankar, Shouxiong Huang, Senad Divanovic, Ian P. Lewkowich   +6 more
wiley   +1 more source

Analysis of Human Thymopoiesis Reveals Rapid Postnatal Remodeling of Thymocytes Within the First 3 Months of Life

European Journal of Immunology, Volume 56, Issue 8, August 2026.
Human thymopoiesis undergoes a dynamic postnatal transition, revealing maximal intrathymic sjTREC production at birth, shifts in thymocyte phenotype and composition, and a transient wave of effector Vδ2+ γδ T cells during early infancy. ABSTRACT The thymus generates a diverse and self‐tolerant T‐cell repertoire.
Camille Kergaravat, Jean‐Marc Doisne, Clarisse Godard, Agata Cieslak, Mourad Amrane, David Vermijlen, Vahid Asnafi, Kamel Benlagha, James P. Di Santo, Emmanuel Clave, Antoine Toubert   +10 more
wiley   +1 more source

Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells

Stem Cell Research & Therapy
Invariant natural killer T (iNKT) cells, upon activation, exhibit antitumor roles by bridging innate and acquired immunity. To overcome the challenges in producing iNKT cells from patients with cancer, we previously developed allogeneic human induced ...
Takahiro Aoki, Midori Kobayashi, Momoko Okoshi, Munechika Yamaguchi, Hiroko Okura, Satoko Sasaki, Yoshie Sasako, Sachiko Kira, Yun-Hsuan Chang, Nayuta Yakushiji-Kaminatsui, Jafar Sharif, Masashi Matsuda, Masahiro Kiuchi, Kiyoshi Hirahara, Motoko Y. Kimura, Shinichiro Motohashi, Haruhiko Koseki   +16 more
doaj   +1 more source

Maternal and infant gut microbiome

iMeta, Volume 5, Issue 4, August 2026.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source

NF-κB is activated in CD4+ iNKT cells by sickle cell disease and mediates rapid induction of adenosine A2A receptors.

PLoS ONE, 2013
Reperfusion injury following tissue ischemia occurs as a consequence of vaso-occlusion that is initiated by activation of invariant natural killer T (iNKT) cells.
Gene Lin, Joshua J Field, Jennifer C Yu, Ruey Ken, Donna Neuberg, David G Nathan, Joel Linden   +6 more
doaj   +1 more source

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

Nature Communications
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for ...
Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai   +19 more
doaj   +1 more source

Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy

Frontiers in Immunology, 2017
Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. Upon activation, iNKT cells are capable of
Melissa Bedard, Mariolina Salio, Vincenzo Cerundolo   +2 more
doaj   +1 more source

Invariant Natural Killer T Cells Ameliorate Monosodium Urate Crystal-Induced Gouty Inflammation in Mice

Frontiers in Immunology, 2017
Gout is an inflammatory arthritis caused by deposition of intra-articular monosodium urate (MSU) crystal. Previous studies have focused on resident macrophage, infiltrating monocyte, and neutrophil responses to MSU crystal; yet the mechanisms of cellular
Jie Wang, Jie Wang, Jie Wang, Qibin Yang, Qibin Yang, Qibin Yang, Quanbo Zhang, Quanbo Zhang, Quanbo Zhang, Congcong Yin, Congcong Yin, Li Zhou, Li Zhou, Li Zhou, Jingguo Zhou, Yangang Wang, Qing-Sheng Mi, Qing-Sheng Mi, Qing-Sheng Mi   +18 more
doaj   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source