Results 91 to 100 of about 15,268 (219)
Immune evasion of the CD1d/NKT cell axis [PDF]
, 2018 Many reviews on the CD1d/NKT cell axis focus on the ability of CD1d-restricted NKT cells to serve as effector cells in a variety of disorders, be they infectious diseases, cancer or autoimmunity.
Brutkiewicz, Randy R. +2 more
core +1 more source
ChemBioChem, Volume 27, Issue 5, 13 March 2026.The glycolipid‐peptide antigen complexes for self‐adjuvanting conjugates were successfully synthesized, and, with the HLA‐transgenic mice, the antigen‐specific CD8+ T cell expansion was exhibited. The results provide useful insights for the design and synthesis of vaccine conjugates using glycolipid antigen as an adjuvant.
Shunya Kikuchi +4 more
wiley +1 more source
The My(c)stery of iNKT cell ontogeny [PDF]
Cell Cycle, 2009 Invariant V alpha 14 bearing natural killer T cells (iNKT) cells constitute a subset of lymphocytes that recognize lipid-based ligands presented by the non-classical MHC class I-like molecule CD1d and responds with rapid cytokine production. Despite their multiple implications in regulating immune responses, pertaining to cancer and auto-immunity, the ...
Marei, Dose, Fotini, Gounari
openaire +2 more sources
Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
eLife, 2019 Tissue homeostasis is critically dependent on the function of tissue-resident lymphocytes, including lipid-reactive invariant natural killer T (iNKT) cells.
Rebeca Jimeno +10 more
doaj +1 more source
Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice. [PDF]
, 2016 Invariant Natural Killer T (iNKT) cells are a unique subset of T lymphocytes that have been implicated in both promoting and suppressing a multitude of immune responses. In mice, iNKT cells express T cell antigen receptors (TCRs) comprising a unique TCRα
Bedel, R. +7 more
core +1 more source
Advanced Science, Volume 13, Issue 18, 27 March 2026.T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu +14 more
wiley +1 more source
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a unique innate T lymphocyte population that possess cytolytic properties and profound immunoregulatory activities. iNKT cells play an important role in the immune surveillance of blood cancers.
Pui Yeng Lam +2 more
doaj +1 more source
Developmental dynamics of post-selection thymic DN iNKT. [PDF]
PLoS ONE, 2012 Invariant natural killer T (iNKT) cells develop in the thymus and branch off from the maturation pathway of conventional T cell at the DP stage. While different stages of iNKT cellular development have been defined, the actual time that iNKT cell ...
Maryam Yassai, Brian Cooley, Jack Gorski
doaj +1 more source
The Evolving Pharmacotherapeutic Landscape for the Treatment of Sickle Cell Disease. [PDF]
, 2020 Sickle cell disease (SCD) is an extremely heterogeneous disease that has been associated with global morbidity and early mortality. More effective and inexpensive therapies are needed.
Ballas, Samir K
core +1 more source
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems [PDF]
, 2011 BACKGROUND: Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin.
Daniela Pende +5 more
core +3 more sources