Results 91 to 100 of about 10,168 (211)
SLAM-ing the brakes on iNKT cell selection [PDF]
Nature Immunology, 2019 Members of the SLAM family of receptors promote the progression of invariant natural killer T cells through the thymic maturation process and facilitate proper host responses to exogenous lipid antigen through the recruitment and activity of SAP–Fyn and SHP-1, respectively.
Shankar S, Iyer +2 more
openaire +2 more sources
iNKT Cells and Their potential Lipid Ligands during Viral Infection
, 2015 Invariant natural killer T (iNKT) cells are a unique population of lipid reactive CD1d restricted innate-like T lymphocytes. Despite being a minor population, they serve as an early source of cytokines and promote immunological crosstalk thus bridging ...
Ponpan eMatangkasombut +1 more
core +1 more source
Immunometabolic Activation of Invariant Natural Killer T Cells
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +1 more source
Nonclassical MHC‐I Molecules: Emerging Therapeutic Targets in Next‐Generation Immunotherapy
MedComm, Volume 7, Issue 5, May 2026.Immunotherapies dependent on classical MHC‐I molecules face significant challenges, including extreme polymorphism and frequent downregulation in pathological conditions. This review discusses how nonclassical MHC‐I molecules (HLA‐E, HLA‐F, HLA‐G, CD1, MR1) may potentially circumvent these limitations through restricted genetic diversity, stable ...
Wanlin He, Andrew J. McMichael
wiley +1 more source
Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model [PDF]
Scientific Reports, 2018 AbstractGraphene oxide (GO) modulates the functions of antigen-presenting cells including dendritic cells (DCs). Although carbon nanotubes affect expression of the MHC class I-like CD1d molecule, whether GO can influence immune responses of CD1d-dependent invariant natural killer T (iNKT) cells remains unclear. Here, we investigated the impact of GO on
Lee, Sung Won +4 more
openaire +2 more sources
Reviews in Medical Virology, Volume 36, Issue 3, May 2026.ABSTRACT Human cytomegalovirus (HCMV) is one of the most important opportunistic pathogens in immunocompromised individuals, including allogeneic haematopoietic stem cell transplant (allo‐HSCT) recipients. In allo‐HSCT, HCMV seropositivity of the recipient and donor is associated with inferior survival outcomes, and post‐transplant HCMV reactivation is
Danya Kaplan +7 more
wiley +1 more source
Development of TCR-engineered iNKT cells for Cancer Immunotherapy
, 2018 Invariant Natural Killer T (iNKT) cells are innate T cells that respond to lipid antigens presented by the molecule CD1d. Activated iNKT cells rapidly produce copious amounts of cytokines, activate/recruit other immune cells and have been implicated in ...
Umana, Juan Mauricio
core +1 more source
From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki +2 more
wiley +1 more source
iNKT cells are activated by Mtb-infected mϕ.
, 2014 (A) iNKT cells were cultured either alone, with uninfected thioglycollate-elicited peritoneal mϕ, or H37Rv-infected mϕ for 24 hours. Cells were stained for CD69 and CD25 and mϕ were distinguished from iNKT cells by F4/80 staining. (B) Fold change in CD69
Cláudio Nunes-Alves (505137) +3 more
core +1 more source
Mixed Signals: T Cells as Architects of IgE Immunity
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney +3 more
wiley +1 more source