Results 101 to 110 of about 10,168 (211)

iNKT cells are activated in the OVA-induced asthma model.

, 2015
A. The percentage of iNKT cells (PBS-57/CD1d+ TCR-β+) in lung MNCs. The gating used for iNKT cells (gate D) and the corresponding percentages are shown in each dot plot. B. Percentage of iNKT cells in lung MNCs from OVA-induced asthmatic mice and WT mice.
Qiaoyu Yang (715852), Jiong Yang (82529), Guqin Zhang (715853), Min Liu (45756), Hanxiang Nie (715851), Xuhong Ding (715855), Suping Hu (715857), Ailing Wang (715854), Yi Huang (112882), Qing He (351975), Hongying Yu (715856), Ping Li (31981)   +11 more
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Preclinical efficacy of combination therapy with allogeneic induced pluripotent stem cell-derived invariant natural killer T and α-galactosylceramide-pulsed antigen-presenting cells

Stem Cell Research & Therapy
Invariant natural killer T (iNKT) cells, upon activation, exhibit antitumor roles by bridging innate and acquired immunity. To overcome the challenges in producing iNKT cells from patients with cancer, we previously developed allogeneic human induced ...
Takahiro Aoki, Midori Kobayashi, Momoko Okoshi, Munechika Yamaguchi, Hiroko Okura, Satoko Sasaki, Yoshie Sasako, Sachiko Kira, Yun-Hsuan Chang, Nayuta Yakushiji-Kaminatsui, Jafar Sharif, Masashi Matsuda, Masahiro Kiuchi, Kiyoshi Hirahara, Motoko Y. Kimura, Shinichiro Motohashi, Haruhiko Koseki   +16 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells [PDF]

, 2020
The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood.
Ohigashi, Izumi, Jenkinson, William E., Lucas, Beth, White, Andrea J., Parnell, Sonia M., Anderson, Graham, Jones, Nick D., Takahama, Yousuke, Cosway, Emilie J., James, Kieran D.   +9 more
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Porcine Invariant Natural Killer T Cells: Functional Profiling and Dynamics in Steady State and Viral Infections

Frontiers in Immunology, 2019
Pigs are important livestock and comprehensive understanding of their immune responses in infections is critical to improve vaccines and therapies. Moreover, similarities between human and swine physiology suggest that pigs are a superior animal model ...
Alexander Schäfer, Jane Hühr, Theresa Schwaiger, Anca Dorhoi, Thomas C. Mettenleiter, Sandra Blome, Charlotte Schröder, Ulrike Blohm   +7 more
doaj   +1 more source

The Histone‐Lysine N‐Methyltransferase (KMT2) Family in Health and Disease

MedComm, Volume 7, Issue 4, April 2026.
This graphical abstract clarifies KMT2 family dysregulation and disease associations: its member mutations cause epigenetic imbalance and abnormal cell development; Menin/WDR5 inhibitors and other targeted therapies block aberrant epigenetic transcriptional programs, and combined synergistic therapies boost therapeutic efficacy.
Qiu Wang, Zunjie Bo, Ya Zhang, Yun Chen, Zhiyu Wang, Shuangmei Tong, Ajing Xu, Jian Zhang, Yan Liu   +8 more
wiley   +1 more source

Characterization of the developmental landscape of murine RORγt+ iNKT cells

, 2019
International audienceInvariant natural killer T (iNKT) cells expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice.
Toubert, Antoine, Brunet, Stéphane, Amable, Ludivine, Lucas, Bruno, Delord, Marc, Marie, Julien,, Eberl, Gérard, Parietti, Véronique, Li, Shamin, Klibi, Jihène, Benlagha, Kamel, Joseph, Claudine, Jaubert, Jean, Marie, Julien, C., Karray, Saoussen   +14 more
core   +1 more source

The autophagy machinery restrains iNKT cell activation through CD1D1 internalization [PDF]

, 2017
Invariant natural killer T (iNKT) cells are innate T cells with powerful immune regulatory functions that recognize glycolipid antigens presented by the CD1D protein.
Keller, Christian W, Jan D. Lünemann (3838321), Loi, M., Christian W. Keller, Gennaro De Libero (589502), Isaak Quast (3838312), Loi, Monica, Theiler, Romina, Ewert, Svenja, Münz, Christian, Loi, M, Monica Loi (3838315), Freigang, S., Monique Gannagé, Monique Gannagé (774489), Keller, CW, De Libero, Gennaro, Freigang, Stefan, Keller, C. W., Romina Theiler, Svenja Ewert (3838324), Stefan Freigang, Quast, I, Münz, C, Theiler, R., Christian W. Keller (3838318), Jan D. Lünemann, Svenja Ewert, Christian Münz, Gannagé, M, Munz, C., Monica Loi, Lunemann, J. D., Gannagé, Monique, Isaak Quast, De Libero, G., Romina Theiler (411647), Lünemann, Jan D, Christian Münz (86294), Stefan Freigang (413363), Quast, Isaak, Lünemann, JD, Ewert, S., Quast, I., Gannage, M., Gennaro De Libero   +45 more
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Image_3_Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection.tif

, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Eva Billerbeck (13764670), Svjetlana Raus (13764661), Jarrett Lopez-Scarim (13764664), Joshua Luthy (13764667)   +3 more
core   +1 more source

Exploiting the potential of iNKT cells to improve vaccination [PDF]

, 2022
Invariant (i)NKT cells are a subset of innate-like T cells that recognize glycolipids (such as α-galactosylceramide; α-GalCer) presented by the non-polymorphic MHC I-like molecule CD1d.
Alwethaynani, Maher
core