Results 101 to 110 of about 15,268 (219)
Advanced Science, Volume 13, Issue 16, 18 March 2026.Radiotherapy induces tumor cells to release microparticles (RT‐MPs) into the circulation. The mitochondrial DNA carried by these RT‐MPs activates the STING/NLRP3/GSDMD axis in splenic neutrophils, triggering IL‐1β secretion. This, in turn, enhances dendritic cell function and facilitates the formation of cytotoxic T lymphocytes, thereby promoting ...
Yan Hu +18 more
wiley +1 more source
, 2014 Natural killer T cells (NKT) are T lymphocytes with a reactivity directed against glycolipid antigens presented by MHC-like CD1d molecules expressed by antigen presenting cells (APC). A large proportion of these cells (invariant NKT cells (iNKT)) possess strong immunomodulatory properties which impose a profound impact on the development and course of ...
openaire +1 more source
Alpha-Galactosylceramide/CD1d-Antibody Fusion Proteins Redirect Invariant Natural Killer T Cell Immunity to Solid Tumors and Promote Prolonged Therapeutic Responses. [PDF]
, 2017 Major progress in cancer immunotherapies have been obtained by the use of tumor targeting strategies, in particular with the development of bi-functional fusion proteins such as ImmTacs or BiTes, which engage effector T cells for targeted elimination of ...
Donda, A., Zhang, L.
core +1 more source
Advanced Science, Volume 13, Issue 14, 9 March 2026.Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang +7 more
wiley +1 more source
Kinetics and cellular site of glycolipid loading control [PDF]
, 2009 CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja +10 more
core
Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]
, 2015 We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F +3 more
core +3 more sources
European Journal of Immunology, Volume 56, Issue 3, March 2026.This is an update to the Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (Third Edition), Chapter 12C, by Cossarizza et al. A 38‐marker full‐spectrum flow cytometry panel enabling high‐resolution profiling of human γδ T cells across blood and lymphoid tissues, including robust identification of rare, tissue‐adapted ...
Mohamed Hamed +8 more
wiley +1 more source
Immunometabolic Activation of Invariant Natural Killer T Cells
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +1 more source
Significance of frequencies, compositions and/or antileukemic activity of (DC-stimulated) invariant NKT, NK and CIK cells on the outcome of patients with AML, ALL and CLL [PDF]
, 2018 Invariant natural killer cells (iNKT cells), natural killer cells (NKT cells) and cytokine induced killer cells (CIK cells) and their subsets are important for immune-surveillance.
Böck, Corinna Lesley
core
Alcohol Abstinence Does Not Fully Reverse Abnormalities of Mucosal-Associated Invariant T Cells in the Blood of Patients With Alcoholic Hepatitis [PDF]
, 2019 OBJECTIVES: Alcoholic hepatitis (AH) develops in approximately 30% of chronic heavy drinkers. The immune system of patients with AH is hyperactivated, yet ineffective against infectious diseases.
Bolte +48 more
core +1 more source