Results 111 to 120 of about 10,168 (211)

Image_6_Hepatic iNKT cells produce type 2 cytokines and restrain antiviral T cells during acute hepacivirus infection.tif

, 2022
Chronic hepatitis C virus (HCV) infection is a curable disease, but the absence of a vaccine remains a major problem in infection prevention. The lack of small animal models and limited access to human liver tissue impede the study of hepatic antiviral ...
Eva Billerbeck (13764670), Svjetlana Raus (13764661), Jarrett Lopez-Scarim (13764664), Joshua Luthy (13764667)   +3 more
core   +1 more source

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

Nature Communications
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for ...
Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai   +19 more
doaj   +1 more source

Lineage differentiation program of iNKT cells

, 2017
iNKT cells develop as memory T cells in the thymus and differentiate into various effector lineages. Recently, we have defined three subsets of iNKT cells (NKT1, NKT2 and NKT17) that produced IFN IL4 and IL17 respectively in the thymus. In the periphery,
LEE, You Jeong
core  

CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells [PDF]

, 2018
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear.
Mauri, C, E. C. Rosser, Rosser, EC, Nistala, K, Drozdov, I, K. Nistala, C. Mauri, Oleinika, K, Matei, DE, D. E. Matei, Bosma, A, A. Bosma, K. Oleinika, I. Drozdov   +13 more
core   +1 more source

Artificial thymic organoid culture generates functional iPSC-derived CD4+ invariant natural killer T cells

Communications Biology
Invariant NKT (iNKT) cells have a T-cell receptor that is common to all individuals and are activated by recognizing glycolipids on MHC class I-like CD1d molecules.
Sara Shiina, Tatsuki Ueda, Shoichi Iriguchi, Yasushi Uemura, Shin Kaneko   +4 more
doaj   +1 more source

An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

, 2010
Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells (iNKT cells).
Strieter, R.M., Chaconas, G., Kubes, P., Woo-Yong Lee, Moriarty, T. J., Hong Zhou, Robert M Strieter, van Rooijen, N., Lee, W. Y., George Chaconas, Zhou, H., Paul Kubes, Lee, W.Y., Wong, C.H.Y., Tara J Moriarty, Wong, C. H., Rooijen, N. van, Moriarty, T.J., Zhou, H, Strieter, R. M., Connie H Y Wong, Nico van Rooijen   +21 more
core   +1 more source

The A2aR adenosine receptor controls cytokine production in iNKT cells

, 2010
The purine nucleoside adenosine is an important anti-inflammatory molecule, inhibiting a variety of immune cells by adenosine receptor-mediated mechanisms.
Mark. A. Exley, Michail Sitkovsky, Exley, Mark A., Lydia Lynch, Simon Yue, Akio Ohta, Michael Nowak, Sitkovsky, Michail, Yue, Simon, Balk, Steven P., Nowak, Michael, Ohta, Akio, Steven P. Balk, Lynch, Lydia   +13 more
core   +1 more source

MAIT and iNKT cells in tissue homeostasis and repair

Immunobiology
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting phenotypes.
Paiva, Rafael Almeida, Salou, Marion
openaire   +3 more sources

Quantification of iNKT cells in HSP2 patients.

, 2013
Flow cytometric quantification of iNKT cells in isolated PBMC from HPS2 patients and two control subjects concomitantly stained. A, The proportion of iNKT cells was calculated on the CD3+ population (at least 250,000 events acquired) contained in the ...
Sylvain Latour (266419), Daniele Moratto (489789), Luisa Lorenzi (489787), Giovanna Tabellini (489788), Genevieve de Saint Basile (489793), Raffaele Badolato (489796), Silvano Sozzani (376589), Silvia Parolini (489797), Lucia D. Notarangelo (489791), Ornella Patrizi (489792), David Pace (489794), Fabio Facchetti (376587), Fulvio Porta (489790), William Vermi (376579), Silvia Lonardi (489795)   +14 more
core   +1 more source

Lipid antigen presentation and thymic selection of iNKT cells [PDF]

, 2009
The previous introductory part has reviewed the current knowledge on CD1 and lipid immunology. Although the last 20 years witnessed a dramatic expansion of the field, many aspects remain elusive and require additional studies.
Facciotti, Federica
core   +1 more source