Results 121 to 130 of about 15,268 (219)

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]

, 2019
Dysregulated IL-23/IL-17 responses have been linked to psoriatic arthritis and other forms of spondyloarthritides (SpA). ROR gamma t, the key Thelperl7 (Th17) cell transcriptional regulator, is also expressed by subsets of innate-like T cells, including ...
Coudenys, Julie, Cypers, Heleen, Decruy, Tine, Elewaut, Dirk, Gyselbrecht, Lieve, Harcken, Christian, Hoyt, Kathleen, Hughes, Robert, Jacques, Peggy, Labadia, Mark E., Martens, Liesbet, Mortier, Céline, Nabozny, Gerald, Piette, Yves, Saeys, Yvan, Schryvers, Nadia, Smith, Dustin, Turner, Michael, Van Calenbergh, Serge, Van den Bosch, Filip, Van Gassen, Sofie, Varkas, Gaëlle, Venken, Koen, Verheugen, Eveline, Wahle, Joseph, Wang, Chao-Ting, Wayne, Anita L., Wittoek, Ruth   +27 more
core   +3 more sources

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

Nature Communications
Dysfunction of invariant natural killer T (iNKT) cells contributes to immune resistance of tumors. Most mechanistic studies focus on their static functional status before or after activation, not considering motility as an important characteristic for ...
Chenxi Tian, Yu Wang, Miya Su, Yuanyuan Huang, Yuwei Zhang, Jiaxiang Dou, Changfeng Zhao, Yuting Cai, Jun Pan, Shiyu Bai, Qielan Wu, Sanwei Chen, Shuhang Li, Di Xie, Rong Lv, Yusheng Chen, Yucai Wang, Sicheng Fu, Huimin Zhang, Li Bai   +19 more
doaj   +1 more source

An expanding range of targets for kynurenine metabolites of tryptophan [PDF]

, 2013
The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail, Stone, Trevor W., Stoy, Nicholas   +2 more
core   +1 more source

The Role of Invariant NKT in Autoimmune Liver Disease: Can Vitamin D Act as an Immunomodulator?

Canadian Journal of Gastroenterology and Hepatology, 2018
Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety of glycolipid antigens ...
Daniel S. Smyk, Athanasios Mavropoulos, Giorgina Mieli-Vergani, Diego Vergani, Marco Lenzi, Dimitrios P. Bogdanos   +5 more
doaj   +1 more source

Effects of Invariant NKT Cells on Parasite Infections and Hygiene Hypothesis

Journal of Immunology Research, 2016
Invariant natural killer T (iNKT) cells are unique subset of innate-like T cells recognizing glycolipids. iNKT cells can rapidly produce copious amounts of cytokines upon antigen stimulation and exert potent immunomodulatory activities for a wide variety
Jun-Qi Yang, Yonghua Zhou, Ram Raj Singh
doaj   +1 more source

Rat iNKT Cells: Phenotype and Function [PDF]

, 2010
iNKT Zellen sind eine Population von T Zellen mit einigen Besonderheiten. Anders als die meisten αβ T Zellen, deren T Zell Rezeptoren (TZRs) für von hochpolymorphen MHC Molekülen präsentierte Peptide spezifisch sind, erkennen iNKT Zellen Glycolipide die von CD1d, einem nicht polymorphem MHC-I artigen Moleküle, präsentiert werden.
openaire   +1 more source

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Genetic Regulation of NKT Cell Function [PDF]

, 2017
NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core   +1 more source

Limiting iNKT cells [PDF]

Nature Immunology, 2014
openaire   +1 more source

Invariant NKT cells are expanded in peripheral blood but are undetectable in salivary glands of patients with primary Sj\uf6gren's syndrome. [PDF]

, 2016
OBJECTIVES: Invariant NKT (iNKT) cells play a role in regulating the function of autoreactive B cells before their entry into germinal centres. Absence and/or reduction of iNKT cells have been demonstrated in patients with systemic lupus erythematosus ...
Alessandro R, Ciccia F, Dieli F, Giardina G, Guggino G, Raimondo S, Sireci G, Triolo G   +7 more
core