Increased expression of two alternative spliced variants of CD1d molecule in human gastric cancer [PDF]
, 2015 Background: CD1d presents glycolipid antigens to invariant natural killer T (iNKT) cells. The role of CD1d in the development of peptic ulcer and gastric cancer has not been revealed, yet.
Ajami, A. +5 more
core
CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells [PDF]
, 2018 Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear.
Bosma, A +6 more
core +2 more sources
Mixed Signals: T Cells as Architects of IgE Immunity
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Food allergen‐specific IgE can cause significant pathology, yet the pathways that generate pathogenic, high‐affinity IgE remain incompletely understood. Increasing evidence suggests that IgE responses arise from the integration of multiple, and sometimes opposing, T cell–derived cues.
Abigail L. Tierney +3 more
wiley +1 more source
Traversing the bench to bedside journey for iNKT cell therapies
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are immune cells that harness properties of both the innate and adaptive immune system and exert multiple functions critical for the control of various diseases.
Julie O’Neal +6 more
doaj +1 more source
Frontiers in Immunology, 2021 Invariant Natural Killer T (iNKT) cells are a small and distinct population of T cells crucial in immunomodulation. After activation by alpha-GalactosylCeramide (αGC), an exogenic glycolipid antigen, iNKT cells can rapidly release cytokines to enhance ...
Ching-Lien Wu +10 more
doaj +1 more source
A computational high-throughput screening approach of iNKT-agonists: a novel tool to find optimized iNKT cell ligands [PDF]
, 2013 Depending on the environment and the activating glycolipids, iNKT cells are known to induce T-helper 1 and/or T-helper 2 cytokines. This highly versatile nature makes these innate-like cells very interesting targets for immunomodulation.
ASPESLAGH, SANDRINE +8 more
core
Invariant NKT Cell Response to Dengue Virus Infection in Human [PDF]
, 2014 BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF).
Chan-in, W +10 more
core +4 more sources
Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis
Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz +24 more
wiley +1 more source
A Fungal Glycosphingolipid Directly Activates Natural Killer T Cells and Rapidly Induces Airways Disease [PDF]
, 2014 Aspergillus fumigatusis a saprophytic fungus that is ubiquitous in the environment and commonly associated with allergic sensitization and severe asthma in humans. Although A.
Albacker, Lee A. +8 more
core +1 more source
The Histone‐Lysine N‐Methyltransferase (KMT2) Family in Health and Disease
MedComm, Volume 7, Issue 4, April 2026.This graphical abstract clarifies KMT2 family dysregulation and disease associations: its member mutations cause epigenetic imbalance and abnormal cell development; Menin/WDR5 inhibitors and other targeted therapies block aberrant epigenetic transcriptional programs, and combined synergistic therapies boost therapeutic efficacy.
Qiu Wang +8 more
wiley +1 more source