Differing roles of CD1d2 and CD1d1 proteins in type I natural killer T cell development and function [PDF]
, 2018 MHC class I-like CD1 molecules have evolved to present lipid-based antigens to T cells. Differences in the antigen-binding clefts of the CD1 family members determine the conformation and size of the lipids that are presented, although the factors that ...
Bradbury +22 more
core +4 more sources
Development of Unconventional T Cells Controlled by MicroRNA
Frontiers in Immunology, 2019 Post-transcriptional gene regulation through microRNA (miRNA) has emerged as a major control mechanism of multiple biological processes, including development and function of T cells. T cells are vital components of the immune system, with conventional T
Samantha J. Winter, Andreas Krueger
doaj +1 more source
Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells
Frontiers in Immunology, 2020 Neuroblastoma (NB) is the most common extracranial solid tumor in children and, in the high-risk group, has a 5-year mortality rate of ~50%. The high mortality rate and significant treatment-related morbidities associated with current standard of care ...
Kevin O. McNerney +4 more
doaj +1 more source
α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding. [PDF]
, 2019 Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Chang, Ya-Jen +7 more
core
Invariant NKT Cell Response to Dengue Virus Infection in Human [PDF]
, 2014 BACKGROUND:Dengue viral infection is a global health threat without vaccine or specific treatment. The clinical outcome varies from asymptomatic, mild dengue fever (DF) to severe dengue hemorrhagic fever (DHF).
Chan-in, W +10 more
core +4 more sources
PLoS ONE, 2013 Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet.
M. Dunne +6 more
semanticscholar +1 more source
Activation and Regulation of B Cell Responses by Invariant Natural Killer T Cells
Frontiers in Immunology, 2018 CD1d-restricted invariant natural killer T (iNKT) cells play central roles in the activation and regulation of innate and adaptive immunity. Cytokine-mediated and CD1d-dependent interactions between iNKT cells and myeloid and lymphoid cells enable iNKT ...
D. Doherty +3 more
semanticscholar +1 more source
Differentiation of IL-17-Producing Invariant Natural Killer T Cells Requires Expression of the Transcription Factor c-Maf [PDF]
, 2017 journal ...
HAMADA Michito +5 more
core +1 more source
Role of CD1d- and MR1-Restricted T Cells in Asthma
Frontiers in Immunology, 2018 Innate T lymphocytes are a group of relatively recently identified T cells that are not involved in either innate or adaptive immunity. Unlike conventional T cells, most innate T lymphocytes express invariant T cell receptor to recognize exogenous non ...
Chiaki Iwamura, Toshinori Nakayama
doaj +1 more source
Genetic Regulation of NKT Cell Function [PDF]
, 2017 NKT cells are specialized T cells that play important roles in the host immune response to bacteria and viruses. NKT cells produce a wide variety of cytokines and chemokines after being activated by glycolipids such as α-galactosylceramide (αGalCer ...
Malagic, Murisa
core +1 more source