Results 111 to 120 of about 75,921 (210)

Generation of Human iNKT Cell Lines

Bio-Protocol, 2013
Natural killer T (NKT) cells comprise an important immunoregulatory T cell subset and express cell surface proteins characteristic of both natural killer cells and T cells.
Xiangming Li, Moriya Tsuji, Jonathan Schneck, Tonya Webb   +3 more
doaj   +1 more source

Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]

, 2015
We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F, Rossi, A G, Saunders, Philippa, Norman, J E   +3 more
core   +3 more sources

Breakthrough for Anticancer Immunotherapy: Current Advances in Manufacturing Protocols of Chimeric Antigen Receptor-Based Therapies

Antibodies
Chimeric antigen receptor (CAR)-based immunotherapy has emerged as a transformative strategy in anticancer treatment, driven by advances in CAR construct design, manufacturing platforms, and expansion to diverse immune cell types. The landmark success of
Yuxin Qian, Weiwei Ma, Xiao-Ning Xu
doaj   +1 more source

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells : implications for adoptive immunotherapy after allogeneic stem cell transplantation [PDF]

, 2010
Background: Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Kuçi, Selim, Rettinger, Eva, Voß, Bernhard, Weber, Gerrit, Stais, Miriam, Kreyenberg, Hermann, Willasch, Andre Manfred, Kuçi, Zyrafete, Koscielniak, Ewa, Klöß, Stephan, Laer, Dorothee von, Klingebiel, Thomas, Bader, Peter   +12 more
core   +1 more source

TCR signal strength controls thymic differentiation of iNKT cell subsets

Nature Communications, 2018
Invariant natural killer T (iNKT) cells can be subsetted by their cytokine profiles, but how they develop in the thymus is unclear. Here the authors show, by analysing mice carrying mutant Zap70 genes, that T cell receptor signaling strength induces ...
Kathryn D. Tuttle, S. Harsha Krovi, Jingjing Zhang, Romain Bedel, Laura Harmacek, Lisa K. Peterson, Leonard L. Dragone, Adam Lefferts, Catherine Halluszczak, Kent Riemondy, Jay R. Hesselberth, Anjana Rao, Brian P. O’Connor, Philippa Marrack, James Scott-Browne, Laurent Gapin   +15 more
doaj   +1 more source

Increased expression of two alternative spliced variants of CD1d molecule in human gastric cancer [PDF]

, 2015
Background: CD1d presents glycolipid antigens to invariant natural killer T (iNKT) cells. The role of CD1d in the development of peptic ulcer and gastric cancer has not been revealed, yet.
Ajami, A., Alizadeh-Navaei, R., Farazmandfar, T., Hafezi, N., Hosseini, V., Tehrani, M.   +5 more
core  

How Lipid-Specific T Cells Become Effectors: The Differentiation of iNKT Subsets

Frontiers in Immunology, 2018
In contrast to peptide-recognizing T cells, invariant natural killer T (iNKT) cells express a semi-invariant T cell receptor that specifically recognizes self- or foreign-lipids presented by CD1d molecules.
Haiguang Wang, Kristin A. Hogquist
doaj   +1 more source

High Activation of γδ T Cells and the γδ2pos T-Cell Subset Is Associated With the Onset of Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome, ANRS 12153 CAPRI NK

Frontiers in Immunology, 2019
Background: Human Immunodeficiency Virus 1 (HIV-1) and Mycobacterium Tuberculosis (Mtb) co-infected patients are commonly at risk of immune reconstitution inflammatory syndrome (IRIS) when initiating antiretroviral treatment (ART).
Polidy Pean, Janin Nouhin, Meng Ratana, Yoann Madec, Laurence Borand, Olivier Marcy, Didier Laureillard, Marcelo Fernandez, Françoise Barré-Sinoussi, Laurence Weiss, Laurence Weiss, Daniel Scott-Algara   +11 more
doaj   +1 more source

Latent Mycobacterium tuberculosis Infection Is Associated With a Higher Frequency of Mucosal-Associated Invariant T and Invariant Natural Killer T Cells

Frontiers in Immunology, 2018
Increasing drug resistance and the lack of an effective vaccine are the main factors contributing to Mycobacterium tuberculosis (Mtb) being a major cause of death globally.
Dominic Paquin-Proulx, P. R. Costa, Cassia G. Terrassani Silveira, M. Marmorato, Natalia B. Cerqueira, Matthew S. Sutton, Shelby L. O’Connor, K. Carvalho, D. Nixon, E. Kallas   +9 more
semanticscholar   +1 more source

Type 1 invariant natural killer T cells in chronic inflammation and tissue fibrosis. [PDF]

Front Immunol, 2023
Kumar V, Hertz M, Agro A, Byrne AJ.
europepmc   +1 more source