Results 61 to 70 of about 75,921 (210)

CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells [PDF]

, 2018
Regulatory B cells (Breg) express high levels of CD1d that presents lipid antigens to invariant natural killer T (iNKT) cells. The function of CD1d in Breg biology and iNKT cell activity during inflammation remains unclear.
Bosma, A, Drozdov, I, Matei, DE, Mauri, C, Nistala, K, Oleinika, K, Rosser, EC   +6 more
core   +2 more sources

Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression [PDF]

Bone Marrow Transplantation, 2016
Invariant natural killer T cells (iNKTs) are innate-like lipid-reactive T lymphocytes that express an invariant T-cell receptor (TCR). Following engagement of the iTCR, iNKTs rapidly secrete copious amounts of Th1 and Th2 cytokines and promote the functions of several immune cells including NK, T, B and dendritic cells.
P Guan, H Bassiri, N P Patel, K E Nichols, R Das   +4 more
openaire   +2 more sources

Invariant natural killer T cells are natural regulators of murine spondylarthritis [PDF]

Arthritis & Rheumatism, 2010
AbstractObjectiveTo investigate the role of invariant natural killer T (iNKT) cells in TNFΔARE/+ mice, an animal model of spondylarthritis (SpA) with both gut and joint inflammation.MethodsThe frequency and activation of iNKT cells were analyzed on mononuclear cells from the lymph nodes and livers of mice, using flow cytometry with α‐galactosylceramide/
Peggy, Jacques, Koen, Venken, Katrien, Van Beneden, Hamida, Hammad, Sylvie, Seeuws, Michael B, Drennan, Dieter, Deforce, Gust, Verbruggen, Maria, Apostolaki, George, Kollias, Bart N, Lambrecht, Martine, De Vos, Dirk, Elewaut   +12 more
openaire   +2 more sources

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis

Diabetologia, 2011
Aims/hypothesisThe innate immune cells, invariant natural killer T cells (iNKT cells), are implicated in the pathogenesis of psoriasis, an inflammatory condition associated with obesity and other metabolic diseases, such as diabetes and dyslipidaemia. We
A. Hogan, A. Tobin, T. Ahern, M. Corrigan, Gadintshware Gaoatswe, R. Jackson, Vincent P. O’Reilly, L. Lynch, D. Doherty, P. Moynagh, B. Kirby, J. O’Connell, Donal O’Shea, Donal O’Shea   +13 more
semanticscholar   +1 more source

Conventional, regulatory, and unconventional T cells in the immunologic response to helicobacter pylori [PDF]

, 2008
Infection by the gastroduodenal pathogen Helicobacter pylori elicits a complex immunologic response in the mucosa involving neutrophils, plasma cells, eosinophils, and lymphocytes, of which T cells are the principal orchestrators of immunity.
Moran, Anthony P., O'Keeffe, Joan
core   +1 more source

Invariant natural killer T cells in children with eosinophilic esophagitis [PDF]

Clinical & Experimental Allergy, 2014
SummaryBackgroundEosinophilic esophagitis (EoE) is an atopic disease characterized by eosinophilic inflammation in which dietary antigens (in particular, milk) play a major role. EoE is most likely a mixed IgE and non‐IgE food‐mediated reaction in which overexpression of Th2 cytokines, particularly IL‐13, play a major role; however, the cells ...
S. Jyonouchi, C. Smith, F. Saretta, Valsamma Abraham, K. Ruymann, Prasanna Modayur-Chandramouleeswaran, Mei-Lun Wang, J. Spergel, A. Cianferoni   +8 more
semanticscholar   +3 more sources

Stabilization of cytokine mRNAs in iNKT cells requires the serine-threonine kinase IRE1alpha [PDF]

, 2018
Activated invariant natural killer T (iNKT) cells rapidly produce large amounts of cytokines, but how cytokine mRNAs are induced, stabilized and mobilized following iNKT activation is still unclear.
Bloch, Yehudi, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Iwawaki, Takao, Janssens, Sophie, Lambrecht, Bart, Saeys, Yvan, Savvides, Savvas, Tavernier, Simon, Van der Cruyssen, Renée, Van Gassen, Sofie, Verheugen, Eveline   +13 more
core   +6 more sources

Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential

Frontiers in Immunology, 2017
Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor (TCR) [invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes that recognize glycolipids presented by CD1d molecules.
Christian W. Keller, Stefan Freigang, Jan D. Lünemann, Jan D. Lünemann   +3 more
doaj   +1 more source

Novel in vitro invariant natural killer T cell functional assays

Journal of Immunological Methods, 2021
Invariant Natural Killer T (iNKT) cells are innate lymphocytes bridging the innate and adaptive immune systems and are critical first responders against cancer and infectious diseases. iNKT cell phenotype and functionality are studied using in vitro stimulation assays assessing cytokine response and proliferation capabilities. The most common stimulant
Allison, Balasko, Colin, Graydon, Keith R, Fowke   +2 more
openaire   +2 more sources

The Roles of Liver-Resident Lymphocytes in Liver Diseases

Frontiers in Immunology, 2019
Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and adaptive immunity. In recent years, many studies have shown that multiple types of lymphocytes are resident in the liver, including memory CD8+ T (TRM) cells ...
Yanan Wang, Cai Zhang
doaj   +1 more source