Results 31 to 40 of about 15,260 (267)

Activation strategies for invariant natural killer T cells [PDF]

Immunogenetics, 2016
Invariant natural killer T (iNKT) cells are a specialized T cell subset that plays an important role in host defense, orchestrating both innate and adaptive immune effector responses against a variety of microbes. Specific microbial lipids and mammalian self lipids displayed by the antigen-presenting molecule CD1d can activate iNKT cells through their ...
Ayano C, Kohlgruber, Carlos A, Donado, Nelson M, LaMarche, Michael B, Brenner, Patrick J, Brennan   +4 more
openaire   +2 more sources

Peripheral blood invariant natural killer T cells of pig-tailed macaques. [PDF]

PLoS ONE, 2012
In humans, invariant natural killer T (iNKT) cells represent a small but significant population of peripheral blood mononuclear cells (PBMCs) with a high degree of variability.
Xiangming Li, Patricia Polacino, Raquel Garcia-Navarro, Shiu-Lok Hu, Moriya Tsuji   +4 more
doaj   +1 more source

Adipose invariant natural killer T cells [PDF]

Immunology, 2014
SummaryAdipose tissue is a dynamic organ that makes up a substantial proportion of the body; in severe obesity it can account for 50% of body mass. Details of the unique immune system resident in human and murine adipose tissue are only recently emerging, and so it has remained a largely unexplored and unappreciated immune site until now.
openaire   +2 more sources

Cord blood Vα24-Vβ11 natural killer T cells display a Th2-chemokine receptor profile and cytokine responses [PDF]

, 2011
Background: The fetal immune system is characterized by a Th2 bias but it is unclear how the Th2 predominance is established. Natural killer T (NKT) cells are a rare subset of T cells with immune regulatory functions and are already activated in utero ...
Elfriede Noessner, Krauss-Etschmann, S., Faber Fabienne L., Harner, Susanne, Harner, S., Nadas, Korinna, Leumann-Runge Anke, Leumann-Runge, A., Leumann-Runge, Anke, Susanne Harner, Korinna Nadas, Nadas, K., Joachim Heinrich, Heinrich, Joachim, Fabienne L Faber, Nadas Korinna, Heinrich, J., Noessner Elfriede, Noessner, Elfriede, Anke Leumann-Runge, Schiemann, Matthias, Susanne Krauss-Etschmann, Krauss-Etschmann Susanne, Fabienne L. Faber, Schiemann Matthias, Nößner, E., Faber, Fabienne L., Krauss-Etschmann, Susanne, Schiemann, M., Faber, F.L., Heinrich Joachim, Harner Susanne, Matthias Schiemann   +32 more
core   +1 more source

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Development of invariant natural killer T cells [PDF]

Current Opinion in Immunology, 2016
Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets
openaire   +2 more sources

Redirecting iNKT Cell Antitumor Immunity with α-GalCer/CD1d-scFv Fusion Proteins

, 2021
Invariant natural killer T (iNKT) cells display important properties that could bridge the innate and adaptive immunity, and they have been shown to play key roles in cancer immunotherapy.
Lianjun Zhang, Alena Donda, Zhang, L., Donda, A.   +3 more
core   +1 more source

Intestinal microbes affect phenotypes and functions of invariant natural killer T cells in mice [PDF]

, 2012
Invariant natural killer T (iNKT) cells undergo canonical, Vα14-Jα18 rearrangement of the T-cell receptor (TCR) in mice; this form of the TCR recognizes glycolipids presented by CD1d. iNKT cells mediate many different immune reactions. Their constitutive
McBride, Sarah, Mazmanian, Sarkis K., Mazmanian, Sarkis K, Kronenberg, Mitchell, Krebs, Philippe, Lin, Lin, Stepniak, Dariusz, Wingender, Gerhard, McBride, Sara, Braun, Jonathan, Wei, Bo   +10 more
core   +1 more source

Invariant natural killer T cells are natural regulators of murine spondylarthritis [PDF]

Arthritis & Rheumatism, 2010
AbstractObjectiveTo investigate the role of invariant natural killer T (iNKT) cells in TNFΔARE/+ mice, an animal model of spondylarthritis (SpA) with both gut and joint inflammation.MethodsThe frequency and activation of iNKT cells were analyzed on mononuclear cells from the lymph nodes and livers of mice, using flow cytometry with α‐galactosylceramide/
Peggy, Jacques, Koen, Venken, Katrien, Van Beneden, Hamida, Hammad, Sylvie, Seeuws, Michael B, Drennan, Dieter, Deforce, Gust, Verbruggen, Maria, Apostolaki, George, Kollias, Bart N, Lambrecht, Martine, De Vos, Dirk, Elewaut   +12 more
openaire   +2 more sources

Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer

BMC Cancer, 2018
Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama, Yoshitaka Okamoto   +7 more
doaj   +1 more source