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Development of invariant natural killer T cells. [PDF]
Current Opinion in Immunology, 2016 Invariant natural killer T (iNKT) cells develop into functionally distinct subsets. Each subset expresses a unique combination of transcription factors that regulate cytokine gene transcription upon activation. The tissue distribution and localization within tissues also varies between subsets. Importantly, the relative abundance of the various subsets
L. Gapin
semanticscholar +3 more sources
Invariant natural killer T cells balance B cell immunity. [PDF]
Immunol Rev, 2021 AbstractInvariant natural killer T (iNKT) cells mediate rapid immune responses which bridge the gap between innate and adaptive responses to pathogens while also providing key regulation to maintain immune homeostasis. Both types of important iNKT immune responses are mediated through interactions with innate and adaptive B cells.
Leadbetter EA, Karlsson MCI.
europepmc +4 more sources
Metabolism in Invariant Natural Killer T Cells: An Overview. [PDF]
Immunometabolism, 2021 Abstract Cellular metabolism is critical for generating energy and macromolecules for cell growth and survival. In recent years, the importance of metabolism in mediating T cell differentiation, proliferation, and function has been a hot topic of investigation.
Yarosz EL, Chang CH, Kumar A.
europepmc +3 more sources
Activation strategies for invariant natural killer T cells [PDF]
Immunogenetics, 2016 Invariant natural killer T (iNKT) cells are a specialized T cell subset that plays an important role in host defense, orchestrating both innate and adaptive immune effector responses against a variety of microbes. Specific microbial lipids and mammalian self lipids displayed by the antigen-presenting molecule CD1d can activate iNKT cells through their ...
A. Kohlgruber +4 more
semanticscholar +3 more sources
Cancer Research, 2022 CD1d-restricted invariant natural killer T (iNKT) cells actively patrol the liver and possess valuable antitumor potential. However, clinical trials evaluating administration of iNKT cell-specific agonist α-galactosylceramide (α-GalCer) have failed to ...
Xue Cheng +11 more
semanticscholar +1 more source
MAIT cells come to the rescue in cancer immunotherapy? [PDF]
, 2020 Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells.
Elewaut, Dirk +2 more
core +2 more sources
Id2 regulates hyporesponsive invariant natural killer T cells [PDF]
Immunology & Cell Biology, 2016 While the invariant natural killer T (iNKT)‐cell response to primary stimulation with the glycolipid, α‐galactosylceramide (αGalCer), is robust, the secondary response to this stimulus is muted resulting in a hyporesponsive state characterized by anti‐inflammatory interleukin‐10 (IL‐10) production and high expression of programmed cell death 1 (PD1 ...
Martin H, Stradner +4 more
openaire +2 more sources
ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]
, 2020 CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun +12 more
core +2 more sources
Invariant natural killer T cells and immunotherapy of cancer [PDF]
Clinical Immunology, 2008 Invariant CD1d restricted natural killer T (iNKT) cells are regulatory cells that express a canonical TCR-Valpha-chain (Valpha24.Jalpha18 in humans and Valpha14.Jalpha18 in mice) which recognizes glycolipid antigens presented by the monomorphic CD1d molecule.
Molling, J.W. +6 more
openaire +7 more sources