Invariant Natural Killer T Cells [PDF]
Antibodies, 2013 Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 ...
Antonella Cianferoni
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Immunometabolic Activation of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
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Antitumor Responses of Invariant Natural Killer T Cells [PDF]
Journal of Immunology Research, 2015 Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function.
Jennie B. Altman +3 more
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Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity [PDF]
Frontiers in Immunology, 2018 Tolerance against self-antigens is regulated by a variety of cell types with immunoregulatory properties, such as CD1d-restricted invariant natural killer T (iNKT) cells.
Luc Van Kaer, Lan Wu
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Insights Into Mucosal-Associated Invariant T Cell Biology From Studies of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner +3 more
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Single-cell transcriptomics reveal different maturation stages and sublineage commitment of human thymic invariant natural killer T cells. [PDF]
J Leukoc Biol, 2023 Invariant natural killer T cells are a rare, heterogeneous T-cell subset with cytotoxic and immunomodulatory properties. During thymic development, murine invariant natural killer T cells go through different maturation stages differentiating into ...
Maas-Bauer K +15 more
europepmc +3 more sources
Invariant natural killer T cells and immunotherapy of cancer [PDF]
Clinical Immunology, 2008 Invariant CD1d restricted natural killer T (iNKT) cells are regulatory cells that express a canonical TCR-Valpha-chain (Valpha24.Jalpha18 in humans and Valpha14.Jalpha18 in mice) which recognizes glycolipid antigens presented by the monomorphic CD1d molecule.
Molling, J.W. +6 more
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Reciprocal Crosstalk between Dendritic Cells and Natural Killer T Cells: Mechanisms and Therapeutic Potential [PDF]
Frontiers in Immunology, 2017 Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor (TCR) [invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes that recognize glycolipids presented by CD1d molecules.
Christian W. Keller +3 more
doaj +4 more sources
Antigen specificity of invariant natural killer T-cells [PDF]
Biomedical Journal, 2015 Natural killer T-cells, with an invariant T-cell antigen receptor α-chain (iNKT cells), are unique and conserved subset of lymphocytes capable of altering the immune system through their rapid and potent cytokine responses.
Alysia M. Birkholz, Mitchell Kronenberg
doaj +4 more sources
Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients [PDF]
Frontiers in Immunology, 2018 Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi +4 more
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