Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity [PDF]
Frontiers in Immunology, 2018 Tolerance against self-antigens is regulated by a variety of cell types with immunoregulatory properties, such as CD1d-restricted invariant natural killer T (iNKT) cells.
Luc Van Kaer, Lan Wu
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Tissue-specific functions of invariant natural killer T cells [PDF]
Nature Reviews Immunology, 2018 Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses.
C. Crosby, M. Kronenberg
semanticscholar +5 more sources
Lineage Differentiation Program of Invariant Natural Killer T Cells [PDF]
Immune Network, 2017 Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages.
Dong-il Kwon, You Jeong Lee
core +5 more sources
Immunometabolic Activation of Invariant Natural Killer T Cells [PDF]
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +4 more sources
Antitumor Responses of Invariant Natural Killer T Cells [PDF]
Journal of Immunology Research, 2015 Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function.
Jennie B. Altman +3 more
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Allogeneic CAR Invariant Natural Killer T Cells Exert Potent Antitumor Effects through Host CD8 T-Cell Cross-Priming. [PDF]
Clin Cancer Res, 2021 Purpose: The development of allogeneic chimeric antigen receptor (CAR) T-cell therapies for off-the-shelf use is a major goal that faces two main immunologic challenges, namely the risk of graft-versus-host disease (GvHD) induction by the transferred ...
Simonetta F +11 more
europepmc +2 more sources
Antigen specificity of invariant natural killer T-cells [PDF]
Biomedical Journal, 2015 Natural killer T-cells, with an invariant T-cell antigen receptor α-chain (iNKT cells), are unique and conserved subset of lymphocytes capable of altering the immune system through their rapid and potent cytokine responses.
Alysia M. Birkholz, Mitchell Kronenberg
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Adoptive Transfer of Autologous Invariant Natural Killer T Cells as Immunotherapy for Advanced Hepatocellular Carcinoma: A Phase I Clinical Trial. [PDF]
Oncologist, 2021 Lessons Learned Administration of autologous invariant natural killer T (iNKT) cells was safe and well‐tolerated in patients with hepatocellular carcinoma (Barcelona Clinic Liver Cancer stage B/C).
Gao Y +8 more
europepmc +2 more sources
Invariant natural killer T cells minimally influence gut microbiota composition in mice [PDF]
Gut Microbes, 2022 Invariant Natural Killer T (iNKT) cells are unconventional T cells that respond to glycolipid antigens found in microbes in a CD1d-dependent manner. iNKT cells exert innate-like functions and produce copious amounts of cytokines, chemokines and cytotoxic
Qiaochu Lin +10 more
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The two faces of invariant natural killer T cells
Biomedical Journal, 2015 In this issue of the Biomedical Journal, we take a look at some of the immune system's most peculiar cells, invariant natural killer T cells, which have features of both innate and adaptive cells.
Emma L. Walton
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