Results 11 to 20 of about 13,860 (111)
Invariant Natural Killer T Cells
Antibodies, 2013 Invariant Natural killer T cell (iNKT cells) are a subset of T cells, which are narrowly defined as a T cell lineage expressing a semi-invariant CD1d-restricted T cell Receptors (TCRs) composed by Vα24-Jα18/Vβ11 in human, and Vα14-Jα18/Vβ8,Vβ7, and Vβ2 ...
Antonella Cianferoni
doaj +1 more source
Haematologica, 2013 Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove +4 more
doaj +1 more source
Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients
Frontiers in Immunology, 2018 Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi +4 more
doaj +1 more source
Immunometabolic Activation of Invariant Natural Killer T Cells
Frontiers in Immunology, 2018 Invariant natural killer T (iNKT) cells are lipid-reactive T cells with profound immunomodulatory potential. They are unique in their restriction to lipid antigens presented in CD1d molecules, which underlies their role in lipid-driven disorders such as ...
Francesca A. Ververs +7 more
doaj +1 more source
BMC Cancer, 2018 Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita +7 more
doaj +1 more source
Antigen specificity of invariant natural killer T-cells
Biomedical Journal, 2015 Natural killer T-cells, with an invariant T-cell antigen receptor α-chain (iNKT cells), are unique and conserved subset of lymphocytes capable of altering the immune system through their rapid and potent cytokine responses.
Alysia M. Birkholz, Mitchell Kronenberg
doaj +1 more source
Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections
Frontiers in Immunology, 2018 The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein +6 more
doaj +1 more source
Homeostatic regulation of marginal zone B cells by invariant natural killer T cells. [PDF]
PLoS ONE, 2011 Marginal zone B cells (MZB) mount a rapid antibody response, potently activate naïve T cells, and are enriched in autoreactive B cells. MZBs express high levels of CD1d, the restriction element for invariant natural killer T cells (iNKT).
Xiangshu Wen +3 more
doaj +1 more source
Activation mechanisms of invariant natural killer T cells (iNKTs)
Iatreia, 2016 A great amount of knowledge on natural killer T cells (iNKTs) is now available, but a consensus about their activation mechanisms has not been reached. These cells recognize different glycolipid antigens through the CD1d molecule.
Baena, Andrés +2 more
doaj +1 more source
Antitumor Responses of Invariant Natural Killer T Cells
Journal of Immunology Research, 2015 Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function.
Jennie B. Altman +3 more
doaj +1 more source