Results 21 to 30 of about 15,260 (267)
The Role Of Invariant Natural Killer T Cells In Cancer [PDF]
International Blood Research & Reviews, 2013 Invariant natural killer T (iNKT) cells are a unique subset of T lymphocytes that recognize glycolipid antigens presented by the class I-like non-polymorphic histocompatibility complex (MHC) molecule, CD1d. They express both innate and adaptive immune cells’ surface receptors, but act more like cells of the innate immune system.
Nur, Haneen +4 more
core +5 more sources
Lineage Differentiation Program of Invariant Natural Killer T Cells [PDF]
Immune Network, 2017 Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages. Promyelocytic leukemia zinc finger (PLZF) modulates this process, and PLZFhigh, PLZFintermediate, and PLZFlow iNKT cells are ...
Dong-il Kwon, You Jeong Lee
openaire +5 more sources
Deficiency of invariant natural killer T cells in coeliac disease [PDF]
Gut, 2006 Background: Immunoregulatory invariant natural killer (iNK) T cells rapidly produce interleukin (IL)-4 and other cytokines that suppress a Th1 response and are deficient in some autoimmune diseases. Aim: The aim of this study was to ...
Grose, R., Cummins, A., Thompson, F.
openaire +4 more sources
Invariant natural killer T cells and mucosal-associated invariant T cells in multiple sclerosis
Immunology Letters, 2017 Multiple sclerosis (MS) is a chronic progressive inflammatory demyelinating disorder of the central nervous system, and in several countries is a leading cause of permanent neurological disability in young adults, particularly women. MS is considered an autoimmune disease, caused by an aberrant immune response to environmental triggers in genetically ...
Elena, Bianchini +6 more
openaire +3 more sources
Invariant natural killer T cells in hematopoietic stem cell transplantation: killer choice for natural suppression [PDF]
Bone Marrow Transplantation, 2016 Invariant natural killer T cells (iNKTs) are innate-like lipid-reactive T lymphocytes that express an invariant T-cell receptor (TCR). Following engagement of the iTCR, iNKTs rapidly secrete copious amounts of Th1 and Th2 cytokines and promote the functions of several immune cells including NK, T, B and dendritic cells.
P Guan +4 more
openaire +3 more sources
Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections [PDF]
Frontiers in Immunology, 2018 The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein +6 more
doaj +4 more sources
Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. Upon activation, iNKT cells are capable of
Melissa Bedard +2 more
doaj +4 more sources
The interaction between invariant Natural Killer
Immunology, 2018 SummaryThe surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal microbiota is tightly controlled and regulated.
Fatma Zehra Hapil, Gerhard Wingender
openaire +5 more sources
Metabolism in Invariant Natural Killer T Cells: An Overview. [PDF]
Immunometabolism, 2021 Abstract Cellular metabolism is critical for generating energy and macromolecules for cell growth and survival. In recent years, the importance of metabolism in mediating T cell differentiation, proliferation, and function has been a hot topic of investigation.
Yarosz EL, Chang CH, Kumar A.
europepmc +3 more sources
Invariant Natural Killer T cells coordinate removal of senescent cells. [PDF]
Med, 2021 The failure of immune surveillance to remove senescent cells drive age-related diseases. Here, we target an endogenous immune surveillance mechanism that can promote elimination of senescent cells and reverse disease progression.We identify a class of lipid-activated T cells, invariant natural killer T cells (iNKTs) are involved in the removal of ...
Arora S +11 more
europepmc +5 more sources