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The two faces of invariant natural killer T cells
Biomedical Journal, 2015 In this issue of the Biomedical Journal, we take a look at some of the immune system's most peculiar cells, invariant natural killer T cells, which have features of both innate and adaptive cells.
Emma L. Walton
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Unraveling Natural Killer T-Cells Development
Frontiers in Immunology, 2018 Natural killer T-cells are a subset of innate-like T-cells with the ability to bridge innate and adaptive immunity. There is great interest in harnessing these cells to improve tumor therapy; however, greater understanding of invariant NKT (iNKT) cell ...
Sabrina Bianca Bennstein
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Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
Nature Communications, 2020 Innate-like T cells such as invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells both develop in the thymus. Here the authors use single-cell RNA sequencing to show that mouse iNKT and MAIT share components of developmental ...
S. Harsha Krovi +6 more
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Frontiers in Immunology, 2018 Mucosal-associated invariant T (MAIT) cells and invariant natural killer T (iNKT) cells are innate-like T cells that function at the interface between innate and adaptive immunity.
Lucy C. Garner +3 more
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Natural killer T cell and pathophysiology of asthma [PDF]
Korean Journal of Pediatrics, 2010 Natural killer T (NKT) cell is a special type of T lymphocytes that has both receptor of natural killer (NK) cell (NK1.1, CD161c) and T cell (TCR) and express a conserved or invariant T cell receptor called V?#7284;J?#7288; in mice or Va24 in humans ...
Gwang Cheon Jang
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Therapeutic Potential of Invariant Natural Killer T Cells in Autoimmunity
Frontiers in Immunology, 2018 Tolerance against self-antigens is regulated by a variety of cell types with immunoregulatory properties, such as CD1d-restricted invariant natural killer T (iNKT) cells.
Luc Van Kaer, Lan Wu
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Frontiers in Immunology, 2017 Natural killer T cells carrying a highly conserved, semi-invariant T cell receptor (TCR) [invariant natural killer T (iNKT) cells] are a subset of unconventional T lymphocytes that recognize glycolipids presented by CD1d molecules.
Christian W. Keller +3 more
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The Roles of Liver-Resident Lymphocytes in Liver Diseases
Frontiers in Immunology, 2019 Tissue-resident lymphocytes usually reside in barrier sites and are involved in innate and adaptive immunity. In recent years, many studies have shown that multiple types of lymphocytes are resident in the liver, including memory CD8+ T (TRM) cells ...
Yanan Wang, Cai Zhang
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Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells
Nature Communications, 2020 Thymus is a unique environment hosting the development of many T cell subsets with distinct functions. Here the authors show that medullary thymic epithelial cells (mTEC) are functionally diverse, with LTβR signaling serving differential regulation of ...
Beth Lucas +9 more
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CD1d expression and invariant NKT cell responses in herpesvirus infections
Frontiers in Immunology, 2015 Invariant natural killer T (iNKT) cells are a highly conserved subset of unconventional T lymphocytes that express a canonical, semi-invariant T cell receptor (TCR) and surface markers shared with the natural killer cell lineage.
Rusung eTan
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