Invariant Natural Killer T and Mucosal-Associated Invariant T Cells in Asthmatic Patients [PDF]
Frontiers in Immunology, 2018 Recent studies have highlighted the heterogeneity of asthma. Distinct patient phenotypes (symptoms, age at onset, atopy, and lung function) may result from different pathogenic mechanisms, including airway inflammation, remodeling, and immune and ...
Guillaume Lezmi +4 more
doaj +3 more sources
Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin-granzyme pathway. [PDF]
Mol Oncol, 2021 Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor immunity.
Díaz-Basabe A +7 more
europepmc +2 more sources
Re-programming mouse liver-resident invariant natural killer T cells for suppressing hepatic and diabetogenic autoimmunity [PDF]
Nature Communications, 2022 Invariant natural killer T (iNKT) cells are tissue-resident immune cells recognizing lipid antigens. Here the authors find that liver, but not lung nor spleen, iNKT cells alter their transcriptome upon systemic treatment of lipid nanoparticles for the ...
Channakeshava Sokke Umeshappa +14 more
doaj +2 more sources
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]
Nature Communications, 2018 Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ...
Meng Zhao +10 more
doaj +5 more sources
Invariant natural killer T cells recognize lipid self-antigen induced by microbial danger signals
Nature Immunology, 2011 Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other inflammatory processes, and these cells can be activated through their T cell antigen receptors by microbial lipid antigens. However, increasing evidence shows
P. Brennan +9 more
semanticscholar +3 more sources
RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients [PDF]
Nature Communications, 2019 The role of innate T cell subsets in the pathogenesis of spondyloarthritis (SpA) is not well understood. Here, the authors examine the role of invariant natural killer T (iNKT) and γδ-T cells in SpA and show that disease-derived iNKT and γδ-T cells have ...
Koen Venken +27 more
doaj +4 more sources
Journal of Experimental Medicine, 2006 Glycolipid ligands for invariant natural killer T cells (iNKT cells) are loaded onto CD1d molecules in the late endosome/lysosome. Accumulation of glycosphingolipids (GSLs) in lysosomal storage diseases could potentially influence endogenous and ...
S. Gadola +9 more
semanticscholar +3 more sources
Immunity, 2012 Summary B cells perform many immunological functions, including presenting lipid antigen to CD1d-restricted invariant natural killer T (iNKT) cells, known to contribute to maintaining tolerance in autoimmunity.
A. Bosma +4 more
semanticscholar +3 more sources
Invariant natural killer T cells are functionally impaired in patients with systemic sclerosis [PDF]
Arthritis Research & Therapy, 2019 Background Systemic sclerosis (SSc) is a potentially fatal autoimmune disease that leads to extensive fibrosis of the skin and internal organs. Invariant natural killer T (iNKT) cells are potent immunoregulatory T lymphocytes being able to orchestrate ...
Ann-Christin Pecher +12 more
doaj +2 more sources
Harnessing the Power of Invariant Natural Killer T Cells in Cancer Immunotherapy
Frontiers in Immunology, 2017 Invariant natural killer T (iNKT) cells are a distinct subset of innate-like lymphocytes bearing an invariant T-cell receptor, through which they recognize lipid antigens presented by monomorphic CD1d molecules. Upon activation, iNKT cells are capable of
Melissa Bedard +2 more
doaj +2 more sources