Results 1 to 10 of about 297,440 (273)

Innate-like T cells in children with sickle cell disease.

PLoS ONE, 2019
BACKGROUND:The implication of lymphocytes in sickle cell disease pathogenesis is supported by a number of recent reports. These studies provided evidence for the activation of invariant natural killer T (iNKT) cells in adult patients, but did not ...
Slimane Allali, Céline Dietrich, François Machavoine, Rachel Rignault-Bricard, Valentine Brousse, Mariane de Montalembert, Olivier Hermine, Thiago Trovati Maciel, Maria Leite-de-Moraes   +8 more
doaj   +6 more sources

Cytotoxic FCER1G+ innate-like T cells: new potential for tumour immunotherapy

Signal Transduction and Targeted Therapy, 2022
In a recent study published in Nature , Chou and colleagues fi ne a new evolutionarily conserved class of tumour-elicited immune response mediated by a distinct population of T cell receptor (TCR)-positive FCER1G-expressing innate-like T cells with high ...
Emma Morrish, Jürgen Ruland
doaj   +4 more sources

It Takes “Guts” to Cause Joint Inflammation: Role of Innate-Like T Cells [PDF]

Frontiers in Immunology, 2018
Innate-like T cells such as invariant natural killer T (iNKT) cells and mucosal-associated T (MAIT) cells, characterized by a semi-invariant T cell receptor and restriction toward MHC-like molecules (CD1 and MR1 respectively), are a unique unconventional
Céline Mortier, Céline Mortier, Srinath Govindarajan, Srinath Govindarajan, Koen Venken, Koen Venken, Dirk Elewaut, Dirk Elewaut   +7 more
doaj   +5 more sources

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells [PDF]

Cell, 2016
Summary Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remain obscure.
Saida Dadi, Sagar Chhangawala, Chong Luo   +2 more
exaly   +4 more sources

Distinct Dysfunctional States of Circulating Innate-Like T Cells in Metabolic Disease [PDF]

Frontiers in Immunology, 2020
The immune system plays a significant role in controlling systemic metabolism. Innate-like T (ILT) cells in particular, such as mucosal-associated invariant T (MAIT) cells, invariant natural killer T (iNKT) cells and γδ T cell receptor expressing cells ...
Yanyan Li, Katherine Woods, Amber Parry-Strong, Regan J. Anderson, Celina Capistrano, Aurelie Gestin, Gavin F. Painter, Ian F. Hermans, Jeremy Krebs, Olivier Gasser, Olivier Gasser   +10 more
doaj   +4 more sources

NK Cells and Innate-Like T Cells After Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis

Frontiers in Immunology, 2021
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, in which autoreactive T and B cells play important roles. Other lymphocytes such as NK cells and innate-like T cells appear to be involved as well.
Josefine Ruder, Jordan Rex, Simon Obahor, María José Docampo, Antonia M. S. Müller, Urs Schanz, Ilijas Jelcic, Roland Martin   +7 more
doaj   +2 more sources

Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]

Nature Reviews Immunology, 2013
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Andrea Cerutti, Montserrat Cols, Irène Puga   +2 more
exaly   +2 more sources

Innate-like T lymphocytes in chronic liver disease

Frontiers in Immunology, 2023
In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis.
Maria Papanastasatou, Mihalis Verykokakis   +1 more
doaj   +2 more sources

The distinct MHC‐unrestricted immunobiology of innate‐like and adaptive‐like human γδ T cell subsets—Nature's CAR‐T cells

Immunological Reviews, 2020
Distinct innate‐like and adaptive‐like immunobiological paradigms are emerging for human γδ T cells, supported by a combination of immunophenotypic, T cell receptor (TCR) repertoire, functional, and transcriptomic data.
Carrie R Willcox, Fiyaz Mohammed, Benjamin E Willcox   +2 more
exaly   +2 more sources

Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness

Nature Immunology, 2014
The subclassification of immunology into innate and adaptive immunity is challenged by innate-like T lymphocytes that use innate receptors to respond rapidly to stress despite expressing T cell antigen receptors (TCRs), a hallmark of adaptive immunity ...
Melanie Wencker, Gleb Turchinovich, Livija Deban, Rafael Di Marco Barros, Turchinovich, Gleb, Adrian C Hayday, Cope, Andrew, Hayday, Adrian; id_orcid, Anett Jandke, Jandke, Anett, Wencker, Melanie, DiMarco Barros, Rafael, Andrew Cope, Deban, Livija   +13 more
core   +2 more sources