Chronic stress physically spares but functionally impairs innate-like invariant T cells [PDF]
Cell Reports, 2021 Summary: The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear.
Patrick T. Rudak +12 more
doaj +5 more sources
Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance. [PDF]
Trends Cancer, 2022 Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells.
Barton BE, Chau CH, Figg WD.
europepmc +3 more sources
Innate-like T cells: A promising asset in anti-cancer immunity. [PDF]
Cancer Cell, 2022 In Nature, Chou et al. identify a subset of innate-like αβ T cells with high cytotoxic potential that accumulate in tumors and elicit an anti-tumor response. Given their capacity to maintain an activation state without undergoing exhaustion, these innate-like T cells may represent effective therapeutic agents for cell-based approaches.
Molgora M, Colonna M.
europepmc +3 more sources
Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. [PDF]
Sci Immunol, 2023 Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but polymorphic inhibitory KIR recognizing a B7 family ligand, HHLA2, and is implicated for immune checkpoint targeting.
Palmer WH +21 more
europepmc +5 more sources
Targeting Innate-Like T Cells in Tuberculosis. [PDF]
Front Immunol, 2016 Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human populations. In contrast, innate-like T cells quickly respond to pathogens and display effector functions
Huang S.
europepmc +4 more sources
Distal Lck Promoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells. [PDF]
Immunohorizons, 2021 Abstract Innate-like T cells, including invariant NKT cells, mucosal-associated invariant T (MAIT) cells, and γ δ T (γδT) cells, are groups of unconventional T lymphocytes. They play important roles in the immune system. Because of the lack of Cre recombinase lines that are specific for innate-like T cells, pan–T cell Cre lines are often
Figueroa MG, Parker LM, Krol K, Zhao M.
europepmc +5 more sources
Normality sensing licenses local T cells for innate-like tissue surveillance [PDF]
Nature Immunology, 2022 Abstract The increasing implication of lymphocytes in general physiology and immune surveillance outside of infection poses the question of how their antigen receptors might be involved. Here, we show that macromolecular aggregates of intraepidermal γδ T cell antigen receptors (TCRs) in the mouse skin aligned with and depended on ...
Duncan R. McKenzie +6 more
openaire +4 more sources
Small Molecule Targeting Immune Cells: A Novel Approach for Cancer Treatment
Biomedicines, 2023 Conventional and cancer immunotherapies encompass diverse strategies to address various cancer types and stages. However, combining these approaches often encounters limitations such as non-specific targeting, resistance development, and high toxicity ...
Shilpi Singh +6 more
doaj +1 more source
Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. [PDF]
Cell, 2016 Abstract Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remain obscure.
Dadi S +10 more
europepmc +4 more sources
Innate-like T Cells: Connecting the Dots Linking Microscopic Intestinal Inflammation to Spondyloarthritis. [PDF]
Arthritis Rheumatol, 2023 Zhao M, Kronenberg M.
europepmc +3 more sources