Results 11 to 20 of about 297,440 (273)
Chronic stress physically spares but functionally impairs innate-like invariant T cells [PDF]
Cell Reports, 2021 Summary: The deleterious effects of psychological stress on mainstream T lymphocytes are well documented. However, how stress impacts innate-like T cells is unclear.
Patrick T. Rudak +12 more
doaj +6 more sources
Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes [PDF]
Immunology, 2018 New data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions.
Ayako Kurioka +2 more
exaly +4 more sources
A Transient Developmental Hematopoietic Stem Cell Gives Rise to Innate-like B and T Cells
Cell Stem Cell, 2016 SUMMARY The generation of distinct hematopoietic cell types, including tissue-resident immune cells, distinguishes fetal from adult hematopoiesis. However, the mechanisms underlying differential cell production to generate a layered immune system during ...
Anna E Beaudin +2 more
exaly +6 more sources
Innate-like T cells: a promising asset in anti-cancer immunity
Cancer Cell, 2022 In Nature, Chou et al. identify a subset of innate-like αβ T cells with high cytotoxic potential that accumulate in tumors and elicit an anti-tumor response. Given their capacity to maintain an activation state without undergoing exhaustion, these innate-
Martina Molgora, M. Colonna
semanticscholar +3 more sources
Innate-like T cells in liver disease.
Trends in ImmunologyMammalian innate-like T cells (ILTCs), including mucosal-associated invariant T (MAIT), natural killer T (NKT), and γδ T cells, are abundant tissue-resident lymphocytes that have recently emerged as orchestrators of hepatic inflammation, tissue repair ...
Albert Ying-Po Yang +3 more
semanticscholar +4 more sources
MAITs and their mates: “Innate-like” behaviors in conventional and unconventional T cells
Clinical and Experimental Immunology, 2023 Summary Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses.
C. Hackstein, P. Klenerman
semanticscholar +3 more sources
Targeting Innate-Like T Cells in Tuberculosis [PDF]
Frontiers in Immunology, 2016 Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human ...
Shouxiong Huang
semanticscholar +3 more sources
bioRxiv, 2023 The “innate-like” T cell compartment, known as Tinn, represents a diverse group of T cells that straddle the boundary between innate and adaptive immunity, having the ability to mount rapid responses following activation.
Liyen Loh +12 more
semanticscholar +3 more sources
Normality sensing licenses local T cells for innate-like tissue surveillance [PDF]
Nature Immunology, 2022 The increasing implication of lymphocytes in general physiology and immune surveillance outside of infection poses the question of how their antigen receptors might be involved.
Duncan R. McKenzie +6 more
semanticscholar +5 more sources
Blood, 2022 T cells expressing chimeric antigen receptors (CARs) have achieved major clinical successes in patients with hematologic malignancies. However, these treatments remain largely ineffective in solid cancers and require significant time and resources to ...
Amy N. Courtney +2 more
semanticscholar +3 more sources