Results 11 to 20 of about 502,944 (241)

Innate-like T cells: A promising asset in anti-cancer immunity. [PDF]

Cancer Cell, 2022
In Nature, Chou et al. identify a subset of innate-like αβ T cells with high cytotoxic potential that accumulate in tumors and elicit an anti-tumor response. Given their capacity to maintain an activation state without undergoing exhaustion, these innate-like T cells may represent effective therapeutic agents for cell-based approaches.
Molgora M, Colonna M.
europepmc   +3 more sources

Self-reactive, innate-like T cells enhance cytotoxicity and immunosurveillance. [PDF]

Trends Cancer, 2022
Checkpoint blockade and adoptive T cell therapy are efficacious in some patients, but many do not respond to these immunotherapies. Chou et al. recently elucidated the characteristics of a new cell population with greater cytotoxicity, improved tumor homing, and reduced exhaustion compared to conventional cytotoxic T cells.
Barton BE, Chau CH, Figg WD.
europepmc   +3 more sources

Targeting Innate-Like T Cells in Tuberculosis. [PDF]

Front Immunol, 2016
Peptide-specific conventional T cells have been major targets for designing most antimycobacterial vaccines. Immune responses mediated by conventional T cells exhibit a delayed onset upon primary infection and are highly variable in different human populations. In contrast, innate-like T cells quickly respond to pathogens and display effector functions
Huang S.
europepmc   +4 more sources

Polymorphic KIR3DL3 expression modulates tissue-resident and innate-like T cells. [PDF]

Sci Immunol, 2023
Most human killer cell immunoglobulin-like receptors (KIR) are expressed by natural killer (NK) cells and recognize HLA class I molecules as ligands. KIR3DL3 is a conserved but polymorphic inhibitory KIR recognizing a B7 family ligand, HHLA2, and is implicated for immune checkpoint targeting.
Palmer WH, Leaton LA, Campos Codo A, Crute B, Roest J, Zhu S, Petersen J, Tobin RP, Hume PS, Stone M, van Bokhoven A, Gerich ME, McCarter MD, Zhu Y, Janssen WJ, Vivian JP, Trowsdale J, Getahun A, Rossjohn J, Cambier J, Loh L, Norman PJ.   +21 more
europepmc   +4 more sources

PLZF play as an indirect facilitator of thymic retention for the innate-like T-cells to aquire innate-like functions. [PDF]

Cell Death Dis, 2018
Cao X, Ma XX, Xue YJ, Zeng Y, Zhang XY, Lu Y, Du JL, Ma P, Chang QY, Li LJ, Zhou XY, Cai KZ, Kovalovsky D, Ma ZR.   +13 more
europepmc   +4 more sources

Thymic Epithelial Cell-Derived IL-15 and IL-15 Receptor α Chain Foster Local Environment for Type 1 Innate Like T Cell Development

Frontiers in Immunology, 2021
Expression of tissue-restricted antigens (TRAs) in thymic epithelial cells (TECs) ensures negative selection of highly self-reactive T cells to establish central tolerance.
Huishan Tao, Lei Li, Nan-Shih Liao, Kimberly S. Schluns, Shirley Luckhart, John W. Sleasman, Xiao-Ping Zhong, Xiao-Ping Zhong, Xiao-Ping Zhong   +8 more
doaj   +1 more source

MAITs and their mates: “Innate-like” behaviors in conventional and unconventional T cells

Clinical and Experimental Immunology, 2023
Summary Most CD4 and CD8 T cells are restricted by conventional major histocompatibility complex (MHC) molecules and mount TCR-dependent adaptive immune responses. In contrast, MAIT, iNKT, and certain γδ TCR bearing cells are characterized by their abilities to recognize antigens presented by unconventional antigen-presenting molecules ...
Hackstein, C-P, Klenerman, P
openaire   +2 more sources

The changing immune landscape of innate-like T cells and other innate cells throughout life. [PDF]

Immunol Cell Biol
Abstract Spectral flow cytometry is an advanced immunological tool that can enable comprehensive analysis of the immune system by simultaneously comparing innate and adaptive immune cells. Here, using a 40‐color antibody panel, we advance our knowledge of innate‐like cells by investigating chemokine receptors and ...
Taheri M, Menne C, Anderson J, Perriman L, Li S, Berzins SP, Licciardi PV, Ashhurst TM, Jalali S, Pellicci DG.   +9 more
europepmc   +3 more sources

Innate-like T lymphocytes in chronic liver disease

Frontiers in Immunology, 2023
In addition to its metabolic activities, it is now clear that the liver hosts a number of diverse immune cell types that control tissue homeostasis.
Maria Papanastasatou, Mihalis Verykokakis   +1 more
doaj   +1 more source

Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells. [PDF]

Cell, 2016
Abstract Malignancy can be suppressed by the immune system in a process termed immunosurveillance. However, to what extent immunosurveillance occurs in spontaneous cancers and the composition of participating cell types remain obscure.
Dadi S, Chhangawala S, Whitlock BM, Franklin RA, Luo CT, Oh SA, Toure A, Pritykin Y, Huse M, Leslie CS, Li MO.   +10 more
europepmc   +4 more sources