Results 1 to 10 of about 2,013 (70)

Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells

Frontiers in Immunology, 2023
NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory checkpoints, such as
Francesca Romana Mariotti, Tiziano Ingegnere, Nadine Landolina, Nadine Landolina, Paola Vacca, Enrico Munari, Lorenzo Moretta   +6 more
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Exploiting autophagy balance in T and NK cells as a new strategy to implement adoptive cell therapies

Molecular Cancer, 2023
Autophagy is an essential cellular homeostasis pathway initiated by multiple stimuli ranging from nutrient deprivation to viral infection, playing a key role in human health and disease.
Manuela Giansanti, Tobias Theinert, Sarah Katharina Boeing, Dorothee Haas, Paul-Gerhardt Schlegel, Paola Vacca, Francesca Nazio, Ignazio Caruana   +7 more
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MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells

OncoImmunology, 2023
Natural Killer (NK) cells are important components of the immune system in the defense against tumor growth and metastasis. They release exosomes containing proteins and nucleic acids, including microRNAs (miRNAs).
Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca, Lorenzo Moretta   +8 more
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Innate Lymphoid Cells in the Central Nervous System

Frontiers in Immunology, 2022
Immune cells are present within the central nervous system and play important roles in neurological inflammation and disease. As relatively new described immune cell population, Innate Lymphoid Cells are now increasingly recognized within the central ...
Shuaiwei Wang, Serge A. van de Pavert
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New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Co-infected Patients. [PDF]

PLoS Neglected Tropical Diseases, 2015
Leprosy control is achieved through a fine-tuning of TH1 and TH2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M.
Pedro Henrique Papotto, Solange Maeda, Jane Tomimori, Marília Brasil Xavier, Luiz Vicente Rizzo, Esper Georges Kallas, Karina Inácio Carvalho   +6 more
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A Shared Regulatory Element Controls the Initiation of Tcf7 Expression During Early T Cell and Innate Lymphoid Cell Developments

Frontiers in Immunology, 2020
The transcription factor TCF-1 (encoded by Tcf7) plays critical roles in several lineages of hematopoietic cells. In this study, we examined the molecular basis for Tcf7 regulation in T cells, innate lymphoid cells, and migratory conventional dendritic ...
Christelle Harly, Christelle Harly, Christelle Harly, Devin Kenney, Yueqiang Wang, Yueqiang Wang, Yi Ding, Yongge Zhao, Parirokh Awasthi, Avinash Bhandoola   +9 more
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Innate Lymphoid Cells in Autoimmune Diseases

Frontiers in Immunology, 2022
Innate lymphoid cells (ILC) are a heterogeneous group of immune cells characterized by lymphoid morphology and cytokine profile similar to T cells but which do not express clonally distributed diverse antigen receptors.
Aurelie S. Clottu, Morgane Humbel, Natalia Fluder, Maria P. Karampetsou, Denis Comte   +4 more
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Innate Lymphoid Cells and Myocardial Infarction

Frontiers in Immunology, 2021
Myocardial infarction results from obstruction of a coronary artery that causes insufficient blood supply to the myocardium and leads to ischemic necrosis.
Wenling Yang, Jibin Lin, Jin Zhou, Yuqi Zheng, Shijiu Jiang, Shaolin He, Dazhu Li   +6 more
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Functional Differences Between Human NKp44— and NKp44+ RORC+ Innate Lymphoid Cells

Frontiers in Immunology, 2012
Human RORC+ lymphoid tissue inducer cells are part of a rapidly expanding family of innate lymphoid cells (ILC) that participate in innate and adaptive immune responses as well as in lymphoid tissue (re) modeling.
Kerim eHoorweg, Ferry eCornelissen, Patricia eAparicio-Domingo, Natalie ePapazian, Geert eKazemier, Hergen eSpits, Tom eCupedo   +6 more
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Innate Lymphoid Cells in Renal Inflammation

Frontiers in Immunology, 2020
Since their identification as a separate family of leukocytes, Innate lymphoid cells (ILCs) have been shown to play crucial roles in immune-mediated diseases and repair mechanisms that restore tissue integrity after injury.
Martina Becker, Ann-Christin Gnirck, Jan-Eric Turner   +2 more
doaj   +1 more source