Results 41 to 50 of about 130,824 (258)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Frontiers in Immunology
BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted.
Nadine Landolina, Biancamaria Ricci, Irene Veneziani, Claudia Alicata, Francesca Romana Mariotti, Andrea Pelosi, Linda Quatrini, Eva Piano Mortari, Rita Carsetti, Paola Vacca, Nicola Tumino, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +13 more
doaj   +1 more source

Innate Lymphoid Cells in Human Pregnancy

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ...
João Mendes, João Mendes, João Mendes, João Mendes, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Manuel Santos-Rosa, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto   +18 more
doaj   +1 more source

Innate lymphoid cells: More than just immune cells

Frontiers in Immunology, 2022
Since their discovery, innate lymphoid cells (ILCs) have been described as the innate counterpart of the T cells. Indeed, ILCs and T cells share many features including their common progenitors, transcriptional regulation, and effector cytokine secretion.
Le Xiong, Le Xiong, Stephen L. Nutt, Stephen L. Nutt, Cyril Seillet, Cyril Seillet   +5 more
doaj   +1 more source

Lymphoid microenvironments and innate lymphoid cells in the gut

Trends in Immunology, 2012
Gut-associated lymphoid tissue (GALT) is a sensor region for luminal content and plays an important role in lymphoid maturation, activation and differentiation. It comprises isolated and aggregated lymphoid follicles, cryptopatches (CPs) and tertiary lymphoid tissue. Innate lymphoid cells (ILCs) play a central role within GALT.
Pearson, C, Uhlig, H, Powrie, F
openaire   +4 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response

OncoImmunology
IL-37 is a member of the IL-1 superfamily exerting anti-inflammatory functions in a number of diseases. Extracellular IL-37 triggers the inhibitory receptor IL-1R8 that is known to regulate different NK cell pathways and functional activities including ...
Nadine Landolina, Francesca Romana Mariotti, Andrea Pelosi, Valentina D’Oria, Tiziano Ingegnere, Claudia Alicata, Paola Vacca, Lorenzo Moretta, Enrico Maggi   +8 more
doaj   +1 more source

Innate Lymphoid Cells in Mucosal Immunity

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are innate counterparts of T cells that contribute to immune responses by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells.
Santosh K. Panda, Marco Colonna
doaj   +1 more source

Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency is associated with more severe asthma. Objective: We aimed to assess the immunoregulatory effects of VitD3 food supplementation on asthma manifestation, with
Janina C. Grund, Susanne Krammer, RPh, Zuqin Yang, MSc, Hannah Mitländer, Manfred Rauh, PhD, Sabine Zirlik, MD, Alexander Kiefer, MD, Theodor Zimmermann, MD, Ralf J. Rieker, MD, Carol I. Geppert, MD, Nikolaos G. Papadopoulos, MD, Susetta Finotto, PhD   +11 more
doaj   +1 more source