Results 41 to 50 of about 131,532 (293)
Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 Innate lymphoid cells (ILCs) represent a novel family of developmentally related hematopoietic effectors with central roles in innate immune responses to infections, lymphoid organogenesis, intestinal homeostasis, and wound healing.1 The prototypes of the ILC family are natural killer cells and lymphoid tissue–inducer cells.
Alain, Tedgui, Hafid, Ait-Oufella
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The Role of TOX in the Development of Innate Lymphoid Cells
Mediators of Inflammation, 2015 TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system.
Corey R. Seehus, Jonathan Kaye
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Role of the ITAM-Bearing Receptors Expressed by Natural Killer Cells in Cancer
, 2022 Natural Killer (NK) cells are innate lymphoid cells (ILCs) capable of recognizing and directly killing tumor cells. They also secrete cytokines and chemokines, which participate in the shaping of the adaptive response.
Vivier, Eric +3 more
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OncoImmunologyInterleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina +7 more
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Phenotypic and functional alterations of innate lymphoid cells in hematological malignancies: potential clinical application [PDF]
Exploration of ImmunologyInnate lymphoid cells are lymphocytes that are neither T cells nor B cells. They are relatively rare in lymphoid tissues and peripheral blood and are distinguished by their absence of an adaptive antigen receptor.
Mario Di Gioacchino +6 more
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Tissue localization of natural killer cells dictates surveillance of lung metastasis
Nature CommunicationsThe lung is a common metastatic site for various cancer types. Successful immune surveillance of lung metastasis depends on Natural Killer (NK) cells, but the underlying mechanisms are elusive.
Marijne Vermeer +14 more
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Frontiers in ImmunologyInnate immunity is the first line of defense against infections, including the detection and response to SARS-CoV-2. Cells of the innate system are usually activated within hours after pathogen exposure and do not generate conventional immunological ...
Enrico Maggi +7 more
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Innate Lymphoid Cells and Intestinal Inflammatory Disorders
, 2022 Innate lymphoid cells (ILCs) are a population of lymphoid cells that do not express T cell or B cell antigen-specific receptors. They are largely tissue-resident and enriched at mucosal sites to play a protective role against pathogens.
Mingzhu Zheng, Jinfang Zhu
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma
Frontiers in ImmunologyNeuroblastoma (NB) is an immunologically “cold” tumor with poor or no inflamed substrates as most of solid pediatric tumors (SPT). Consistent data indicate that NB tumor microenvironment (TME) is dominated by myeloid cells, with little (but variable) T ...
Enrico Maggi +7 more
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