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Innate lymphoid cell recovery and occurrence of GvHD after hematopoietic stem cell transplantation
International audienceLymphocytes are essential for microbial immunity, tumor surveillance, and tissue homeostasis. However, the in vivo development and function of helper-like innate lymphoid cells (ILCs) in humans remain much less well understood than ...
Barlogis, Vincent +13 more
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SnapShot: Innate Lymphoid Cells
ILC1 α4β7+ α4β7SnapShot: Innate Lymphoid Cells Gregory F. Sonnenberg,1,3 Jenny Mjosberg,4 Hergen Spits,5 and David Artis2,3 1Departments of Medicine and 2Microbiology, 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 4Karolinska University Hospital Huddinge, Karolinska Institutet, Sweden 5Tytgat Institute for Liver ...
Sonnenberg, Gregory F. +3 more
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Innate Lymphoid Cell Immunometabolism [PDF]
Innate lymphoid cells (ILCs) are tissue-resident "first responders" of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are ...
Timothy E, O'Sullivan, Joseph C, Sun
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Marginal zone B cells: virtues of innate-like antibody-producing lymphocytes [PDF]
Protective responses to microorganisms involve the nonspecific but rapid defence mechanisms of the innate immune system, followed by the specific but slow defence mechanisms of the adaptive immune system. Located as sentinels at the interface between the
Cols, M +5 more
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HiJAKing Innate Lymphoid Cells? [PDF]
The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells. Cytokines acting through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways are key players in both Th and ILC biology.
SCIUME', GIUSEPPE +2 more
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Innate lymphoid cells type 3 in cancer
Cancer is a multifactorial chronic illness caused by a combination of genetic and environmental factors. A tumor is more than just a collection of cancer cells, it also contains infiltrating and resident host cells that are constantly interacting with it.
Valle-Noguera, Ana +8 more
core +1 more source
Innate lymphoid cell memory [PDF]
Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, NK cells recall haptens, viruses ...
Xianwei, Wang, Hui, Peng, Zhigang, Tian
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Innate lymphoid cells in asthma: cannabinoids on the balance. [PDF]
The network of cells and soluble mediators implicated in the pathogenesis of asthma and allergic disorders is complex. Deciphering details of the crosstalk between its components is essential for the identification of novel drug targets and for advances ...
S. von Gunten +3 more
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Innate immunity against HIV: a priority target for HIV prevention research. [PDF]
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W +35 more
core +1 more source
The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation.Innate lymphoid cells encompass several novel cell types whose wide-ranging roles in the ...
David R, Withers +2 more
openaire +2 more sources

