Results 31 to 40 of about 130,824 (258)

Plasticity of Innate Lymphoid Cells in Cancer

Frontiers in Immunology, 2022
Innate lymphoid cells (ILCs) are a heterogenous population of the innate immune system, enriched at mucosal surfaces and are pivotal regulators of immune homeostasis. ILCs are the innate counterpart of T cells. Like T cells, ILC subsets are highly plastic with their composition and function controlled by alterations in their microenvironment.
Bernd Heinrich, Bernd Heinrich, Firouzeh Korangy   +2 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multifunctional-engineered NK cells overcome tumor immunosuppression by combining PD-L1 and HLA-E targeting and endogenous IL15 production

Signal Transduction and Targeted Therapy
The immunosuppressive tumor microenvironment (TME) poses a significant challenge to effective cancer immunotherapy, as it enables tumor escape through redundant checkpoint pathways, metabolic constraints, and direct inhibition of effector cells.
Piera Filomena Fiore, Sergio Forcelloni, Lorenzo Moretta, Maria Rita Assenza, Paola Orecchia, Maria Teresa Bilotta, Markus Machwirth, Ted Shpati, Lokossou William Sanvi, Dorothee Haas, Simone Vitozzi, Manuela Giansanti, Francesca Nazio, Nicola Tumino, Ignazio Caruana, Paola Vacca   +15 more
doaj   +1 more source

IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells

OncoImmunology
Interleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina, Francesca Romana Mariotti, Enrico Munari, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +7 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy supports the storage of lytic granules in human NK cells

Cell Death and Disease
Natural Killer (NK) cells are innate lymphoid cells that play an important role in immune defense against pathogens and tumors. Understanding the mechanisms that enhance NK cell effector functions could significantly improve current NK cell-based ...
Piera Filomena Fiore, Sergio Forcelloni, Simone Vitozzi, Nicola Tumino, Tobias Theinert, Lokossou William Sanvi, Francesca Nazio, Valentina D’Oria, Stefania Martini, Maximilian Reichert, Lorenzo Moretta, Ignazio Caruana, Paola Vacca   +12 more
doaj   +1 more source

The innate immune response in SARS-CoV2 infection: focus on toll-like receptor 4 in severe disease outcomes

Frontiers in Immunology
Innate immunity is the first line of defense against infections, including the detection and response to SARS-CoV-2. Cells of the innate system are usually activated within hours after pathogen exposure and do not generate conventional immunological ...
Enrico Maggi, Nadine Landolina, Francesca Romana Mariotti, Enrico Munari, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta   +7 more
doaj   +1 more source

Phenotypic and functional alterations of innate lymphoid cells in hematological malignancies: potential clinical application [PDF]

Exploration of Immunology
Innate lymphoid cells are lymphocytes that are neither T cells nor B cells. They are relatively rare in lymphoid tissues and peripheral blood and are distinguished by their absence of an adaptive antigen receptor.
Mario Di Gioacchino, Antonio Pagana, Giuseppe Mirabile, Loredana della Valle, Fabio Stagno, Sebastiano Gangemi, Alessandro Allegra   +6 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma

Frontiers in Immunology
Neuroblastoma (NB) is an immunologically “cold” tumor with poor or no inflamed substrates as most of solid pediatric tumors (SPT). Consistent data indicate that NB tumor microenvironment (TME) is dominated by myeloid cells, with little (but variable) T ...
Enrico Maggi, Nadine Landolina, Enrico Munari, Francesca Romana Mariotti, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta   +7 more
doaj   +1 more source