Results 51 to 60 of about 130,824 (258)

Innate lymphoid cells in secondary lymphoid organs

Immunological Reviews, 2016
SummaryThe family of innate lymphoid cells (ILCs) has attracted attention in recent years as its members are important regulators of immunity, while they can also cause pathology. In both mouse and man, ILCs were initially discovered in developing lymph nodes as lymphoid tissue inducer (LTi) cells.
Bar-Ephraïm, JE, Mebius, Reina E.
openaire   +3 more sources

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Innate Lymphoid Cells in Crohn’s Disease

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a large family of cells of the immune system that performs various functions in immune defense, inflammation, and tissue remodeling. As a part of the innate immune system, ILCs are a distinct form of lymphocytes different
Ying Wu, Jun Shen
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

From Cells to Microphysiological Systems: 3D Cell Cultures and Organ-on-Chip Systems for Studying cAMP and cGMP Signaling

Organoids
Cyclic adenosine monophosphate and cyclic guanosine monophosphate are key regulators of cellular physiology and tissue homeostasis. Conventional experimental models have provided fundamental insights into cyclic nucleotide pathways; however, they often ...
Maria Rita Assenza, Nicole Bertani, Martina Pinna, Federica Campolo   +3 more
doaj   +1 more source

Immunoregulatory functions of innate lymphoid cells

Journal for ImmunoTherapy of Cancer, 2018
Innate lymphoid cells (ILCs) are increasingly being recognized for their ability to impact both innate and adaptive immune cells in diverse contexts. ILCs have been observed in all secondary lymphoid tissues, in addition to being tissue-resident innate ...
Sarah Q. Crome, Pamela S. Ohashi
doaj   +1 more source

Innate lymphoid cells in inflammatory arthritis

Arthritis Research & Therapy, 2020
Aberrant activation and dysregulation of immune system is a common feature of many forms of inflammatory arthritis. Since their identification as a distinctive population of leukocytes, innate lymphoid cells (ILCs) have been considered crucial in ...
Weiting Fang, Yuanyuan Zhang, Zhu Chen
doaj   +1 more source

Innate Lymphoid Cells in Inflammation and Immunity [PDF]

Immunity, 2014
Innate lymphoid cells (ILCs) were first described as playing important roles in the development of lymphoid tissues and more recently in the initiation of inflammation at barrier surfaces in response to infection or tissue damage. It has now become apparent that ILCs play more complex roles throughout the duration of immune responses, participating in ...
Mckenzie, Andrew N.J., Spits, Hergen, Eberl, Gerard   +2 more
openaire   +2 more sources

Intracerebral Hemorrhage Induces Monocyte TNF Signaling in Patients That Is Suppressed by BAF312

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Intracerebral hemorrhage (ICH) causes high morbidity and mortality, with neurotoxic inflammation driven by infiltrating monocytes. This study is an in‐depth longitudinal examination of the immune response during the first week of ICH in the presence and absence of the immunomodulatory drug BAF312 (Siponimod).
Jonathan Howard DeLong, Sebastian Díaz‐Pérez, Kevin Navin Sheth, Jang‐Ho Cha, C. J. Malanga, Patricia G. M. Wagner, Nicole Pezous, Aurelie Hanin, Kyle B. Walsh, H. E. Hinson, Lauren Hachmann Sansing   +10 more
wiley   +1 more source

The transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15Rα chain

Frontiers in Immunology
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells ...
Sergio Forcelloni, Julien Giron-Michel, Piero Del Boccio, Piero Del Boccio, Maria Concetta Cufaro, Maria Concetta Cufaro, Alice Di Sebastiano, Alice Di Sebastiano, Francesca Romana Mariotti, Cecilia Ciancaglini, Salem Chouaib, Salem Chouaib, Mael Padelli, Mael Padelli, Simone Vespa, Giang Dang Mac, Stefan Ebert, Stéphanie Buart, Enrico Maggi, Lorenzo Moretta, Paola Vacca, Nicola Tumino, Linda Quatrini, Ignazio Caruana, Bruno Azzarone, Silvia Santopolo   +25 more
doaj   +1 more source