Results 51 to 60 of about 131,532 (293)

Neuroendocrine regulation of innate lymphoid cells

, 2018
International audienceThe activities of the immune system in repairing tissue injury and combating pathogens were long thought to be independent of the nervous system.
Vivier, Eric, Linda Quatrini, Quatrini, Linda, Sophie Ugolini, Eric Vivier, Ugolini, Sophie   +5 more
core   +1 more source

Shaping Innate Lymphoid Cell Diversity [PDF]

Frontiers in Immunology, 2017
Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation.
Qiutong Huang, Qiutong Huang, Cyril Seillet, Cyril Seillet, Gabrielle T. Belz, Gabrielle T. Belz   +5 more
openaire   +6 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Innate Lymphoid Cells in Human Pregnancy

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a new set of cells considered to be a part of the innate immune system. ILCs are classified into five subsets (according to their transcription factors and cytokine profile) as natural killer cells (NK cells), group 1 ...
João Mendes, João Mendes, João Mendes, João Mendes, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Ana Luísa Areia, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Paulo Rodrigues-Santos, Manuel Santos-Rosa, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto, Anabela Mota-Pinto   +18 more
doaj   +1 more source

Innate lymphoid cells: More than just immune cells

Frontiers in Immunology, 2022
Since their discovery, innate lymphoid cells (ILCs) have been described as the innate counterpart of the T cells. Indeed, ILCs and T cells share many features including their common progenitors, transcriptional regulation, and effector cytokine secretion.
Le Xiong, Le Xiong, Stephen L. Nutt, Stephen L. Nutt, Cyril Seillet, Cyril Seillet   +5 more
doaj   +1 more source

Metabolic features of innate lymphoid cells

Journal of Experimental Medicine, 2022
Innate and adaptive immune cells are found in distinct tissue niches where they orchestrate immune responses. This requires intrinsic and temporal metabolic adaptability to coordinately activate the immune response cascade. Dysregulation of this program is a key feature of immunosuppression.
Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz   +2 more
openaire   +5 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Frontiers in Immunology
BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted.
Nadine Landolina, Biancamaria Ricci, Irene Veneziani, Claudia Alicata, Francesca Romana Mariotti, Andrea Pelosi, Linda Quatrini, Eva Piano Mortari, Rita Carsetti, Paola Vacca, Nicola Tumino, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +13 more
doaj   +1 more source

Innate sensing of HIV-infected cells

, 2011
Cell-free HIV-1 virions are poor stimulators of type I interferon (IFN) production. We examined here how HIV-infected cells are recognized by plasmacytoid dendritic cells (pDCs) and by other cells.
Richard E. Randall, Randall, Richard E, Mustapha Si-Tahar, Helen K W Law, Julien Pothlichet, Plumas, Joel, Lepelley, Alice, Mammano, Fabrizio, Helen K. W. Law, Richard E Randall, Schwartz, Olivier, Albert, Matthew L, Albert, Matthew L., Louis, Stephanie, Laurence Chaperot, Chaperot, Laurence, Stéphanie Louis, Pothlichet, Julien, Olivier Schwartz, Si-Tahar, Mustapha, Sourisseau, Marion, Schilte, Clementine, Law, Helen K. W., Law, Helen K W, Marion Sourisseau, Joël Plumas, Alice Lepelley, Clémentine Schilte, Fabrizio Mammano, Matthew L Albert, Matthew L. Albert, Randall, Richard Edward   +31 more
core   +1 more source

Vitamin D3 resolved human and experimental asthma via B lymphocyte–induced maturation protein 1 in T cells and innate lymphoid cells

Journal of Allergy and Clinical Immunology: Global, 2023
Background: Vitamin D3 (VitD3) is known to have immunomodulatory functions, and VitD3 deficiency is associated with more severe asthma. Objective: We aimed to assess the immunoregulatory effects of VitD3 food supplementation on asthma manifestation, with
Janina C. Grund, Susanne Krammer, RPh, Zuqin Yang, MSc, Hannah Mitländer, Manfred Rauh, PhD, Sabine Zirlik, MD, Alexander Kiefer, MD, Theodor Zimmermann, MD, Ralf J. Rieker, MD, Carol I. Geppert, MD, Nikolaos G. Papadopoulos, MD, Susetta Finotto, PhD   +11 more
doaj   +1 more source