Results 71 to 80 of about 131,532 (293)

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

The transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15Rα chain

Frontiers in Immunology
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells ...
Sergio Forcelloni, Julien Giron-Michel, Piero Del Boccio, Piero Del Boccio, Maria Concetta Cufaro, Maria Concetta Cufaro, Alice Di Sebastiano, Alice Di Sebastiano, Francesca Romana Mariotti, Cecilia Ciancaglini, Salem Chouaib, Salem Chouaib, Mael Padelli, Mael Padelli, Simone Vespa, Giang Dang Mac, Stefan Ebert, Stéphanie Buart, Enrico Maggi, Lorenzo Moretta, Paola Vacca, Nicola Tumino, Linda Quatrini, Ignazio Caruana, Bruno Azzarone, Silvia Santopolo   +25 more
doaj   +1 more source

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

, 2019
International audienceInterleukin (IL)-2 is a pleiotropic cytokine that is necessary to prevent chronic inflammation in the gastrointestinal tract 1-4. The protective effects of IL-2 involve the generation, maintenance and function of regulatory T (T reg)
Kabata, Hiroki, Endi K. Santosa, Eric Vivier, Goc, Jeremy, Putzel, Gregory, G, Eberl, Gérard, Gregory F. Sonnenberg, Kendall A. Smith, Teng, Fei, Gérard Eberl, Baldassano, Robert, N, Santosa, Endi, K, Sockolow, Robbyn, E, Robert N. Baldassano, Bessman, Nicholas, J, Hiroki Kabata, Gregory G. Putzel, Chu, Coco, Shah, Manish, A, Lei Zhou, Sonnenberg, Gregory, F, Smith, Kendall, A, Vivier, Eric, Coco Chu, Nicholas J. Bessman, Zhou, Lei, Kelsen, Judith, R, Jeremy Goc, Judith R. Kelsen, Robbyn E. Sockolow, Fei Teng, Manish A. Shah   +31 more
core   +1 more source

Why Innate Lymphoid Cells? [PDF]

, 2018
Innate lymphoid cells (ILCs) are positioned in tissues perinatally, constitutively express receptors responsive to their organ microenvironments, and perform an arsenal of effector functions that overlap those of adaptive CD4+ T cells.
Locksley, Richard M, Kotas, Maya E
core   +1 more source

Innate lymphoid cells in secondary lymphoid organs

Immunological Reviews, 2016
SummaryThe family of innate lymphoid cells (ILCs) has attracted attention in recent years as its members are important regulators of immunity, while they can also cause pathology. In both mouse and man, ILCs were initially discovered in developing lymph nodes as lymphoid tissue inducer (LTi) cells.
Bar-Ephraïm, JE, Mebius, Reina E.
openaire   +3 more sources

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source

Overview of the development, characterization, and function of human types 1, 2, and 3 innate lymphoid cells [PDF]

Einstein (São Paulo)
Hematopoiesis is characterized by the differentiation and maturation of multipotent stem cells into hematopoietic cells. Common lymphoid progenitor cells differentiate into B and T lymphocytes; natural killer cells can also originate from common lymphoid
Laiz Cameirão Bento, Nydia Strachman Bacal, Luciana Cavalheiro Marti   +2 more
doaj   +1 more source

DataSheet_1_GATA2 haploinsufficient patients lack innate lymphoid cells that arise after hematopoietic cell transplantation.pdf [PDF]

, 2022
Innate lymphoid cells (ILC) are important barrier tissue immune regulators. They play a pivotal role in early non-specific protection against infiltrating pathogens, regulation of epithelial integrity, suppression of pro-inflammatory immune responses and
H. Spits (13902258), Zeerleder, S. S., Haverkate, N J E, Blom, B., van Lier, Y F, Hazenberg, M. D., Rutten, C E, Krabbendam, L, L. Krabbendam (13902243), B. Blom (13902255), Zeerleder, S S, Blom, B, M. D. Hazenberg (13902261), Krabbendam, L., C. E. Rutten (13902252), S. S. Zeerleder (13902249), Spits, H, N. J. E. Haverkate (13902246), Haverkate, N. J. E., van Lier, Y. F., Spits, H., Rutten, C. E., Hazenberg, M D, Y. F. van Lier (13902240)   +23 more
core   +1 more source

Intrinsic Photoactive Star ZnPc–Poly(glutamate) Nanoplatforms for Multimodal Glioblastoma Therapy and Brain‐Targeted Delivery

Advanced Functional Materials, EarlyView.
An intrinsic photoactive star‐shaped zinc phtalocyanine‐poly(L‐glutamic acid) (ZnPc‐PGA) nanoplatform for multimodal glioblastoma (GBM) therapy and brain‐targeted elivery. A ZnPc‐PGA‐based multifunctional theranostic nanocarrier platform enables image‐guided, multimodal GBM therapy. ZnPc‐PGA nanocarriers support the integration of fluorescence imaging,
Amina Benaicha‐Fernández, Teodora Ranđelović, Ana Armiñán, Víctor Sebastián, Manuel Fuentes, Cristián Huck‐Iriart, Esther Masiá, Paula Carrascosa‐Marco, Pablo Juanes‐Velasco, Snežana Đorđević, Clara Bayona, Ignacio Ochoa, Maria Medel, Inmaculada Conejos‐Sánchez, María J. Vicent   +14 more
wiley   +1 more source

Physiological Regulation of Innate Lymphoid Cells

Frontiers in Immunology, 2019
Discovery of innate lymphoid cells (ILCs) have provoked a paradigm shift in our understanding of the immune protection. Their constitutive presence and activity at the body's barrier surfaces ensure the maintenance of the tissue homeostasis and immune ...
Nicolas Jacquelot, Nicolas Jacquelot, Kylie Luong, Cyril Seillet, Cyril Seillet   +4 more
doaj   +1 more source