Results 1 to 10 of about 128,560 (293)

NFIL3 Orchestrates the Emergence of Common Helper Innate Lymphoid Cell Precursors

Cell Reports, 2015
Innate lymphoid cells (ILCs) are a family of effectors that originate from a common innate lymphoid cell progenitor. However, the transcriptional program that sets the identity of the ILC lineage remains elusive.
Wei Xu, Rita G. Domingues, Diogo Fonseca-Pereira, Manuela Ferreira, Hélder Ribeiro, Silvia Lopez-Lastra, Yasutaka Motomura, Lara Moreira-Santos, Franck Bihl, Véronique Braud, Barbara Kee, Hugh Brady, Mark C. Coles, Christian Vosshenrich, Masato Kubo, James P. Di Santo, Henrique Veiga-Fernandes   +16 more
doaj   +3 more sources

Sterile Inflammation-Do innate lymphoid cell subsets play a role?

Frontiers in Immunology, 2012
The recent identification of several novel innate lymphoid cell subsets (iLCs) has increased our understanding of the mechanisms which link the innate and adaptive immune systems.
Shane E Russell, Patrick T Walsh
doaj   +3 more sources

Replication of Influenza A Virus in Secondary Lymphatic Tissue Contributes to Innate Immune Activation

Pathogens, 2021
The replication of viruses in secondary lymphoid organs guarantees sufficient amounts of pattern-recognition receptor ligands and antigens to activate the innate and adaptive immune system.
Sarah-Kim Friedrich, Rosa Schmitz, Michael Bergerhausen, Judith Lang, Vikas Duhan, Cornelia Hardt, Matthias Tenbusch, Marco Prinz, Kenichi Asano, Hilal Bhat, Thamer A. Hamdan, Philipp Alexander Lang, Karl Sebastian Lang   +12 more
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Phenotypic and functional alterations of innate lymphoid cells in hematological malignancies: potential clinical application [PDF]

Exploration of Immunology
Innate lymphoid cells are lymphocytes that are neither T cells nor B cells. They are relatively rare in lymphoid tissues and peripheral blood and are distinguished by their absence of an adaptive antigen receptor.
Mario Di Gioacchino, Antonio Pagana, Giuseppe Mirabile, Loredana della Valle, Fabio Stagno, Sebastiano Gangemi, Alessandro Allegra   +6 more
doaj   +1 more source

Distinct Waves from the Hemogenic Endothelium Give Rise to Layered Lymphoid Tissue Inducer Cell Ontogeny

Cell Reports, 2020
Summary: During embryogenesis, lymphoid tissue inducer (LTi) cells are essential for lymph node organogenesis. These cells are part of the innate lymphoid cell (ILC) family.
Milesa Simic, Iris Manosalva, Lionel Spinelli, Rebecca Gentek, Raheleh R. Shayan, Carole Siret, Mathilde Girard-Madoux, Shuaiwei Wang, Lauriane de Fabritus, Janneke Verschoor, Yann M. Kerdiles, Marc Bajenoff, Ralf Stumm, Rachel Golub, Serge A. van de Pavert   +14 more
doaj   +1 more source

Distinct subsets of innate lymphoid cells in nasal polyp

Allergology International, 2023
Background: Group 2 innate lymphoid cells (ILC2s) contribute to the pathogenesis of eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNPs).
Dong Hyun Kim, Ji Youn Lim, Jung Yeon Jang, Jangwook Gwak, Hye Ah Joo, Sungseok Ryu, Ji Heui Kim   +6 more
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Functional Differences Between Human NKp44— and NKp44+ RORC+ Innate Lymphoid Cells

Frontiers in Immunology, 2012
Human RORC+ lymphoid tissue inducer cells are part of a rapidly expanding family of innate lymphoid cells (ILC) that participate in innate and adaptive immune responses as well as in lymphoid tissue (re) modeling.
Kerim eHoorweg, Ferry eCornelissen, Patricia eAparicio-Domingo, Natalie ePapazian, Geert eKazemier, Hergen eSpits, Tom eCupedo   +6 more
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TLR2/4 are novel activating receptors for SARS-CoV-2 spike protein on NK cells

Frontiers in Immunology
BackgroundIn early infected or severe coronavirus disease 2019 (COVID-19) patients, circulating NK cells are consistently reduced, despite being highly activated or exhausted.
Nadine Landolina, Biancamaria Ricci, Irene Veneziani, Claudia Alicata, Francesca Romana Mariotti, Andrea Pelosi, Linda Quatrini, Eva Piano Mortari, Rita Carsetti, Paola Vacca, Nicola Tumino, Bruno Azzarone, Lorenzo Moretta, Enrico Maggi   +13 more
doaj   +1 more source

Deciphering the Innate Lymphoid Cell Transcriptional Program

Cell Reports, 2016
Innate lymphoid cells (ILCs) are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages.
Cyril Seillet, Lisa A. Mielke, Daniela B. Amann-Zalcenstein, Shian Su, Jerry Gao, Francisca F. Almeida, Wei Shi, Matthew E. Ritchie, Shalin H. Naik, Nicholas D. Huntington, Sebastian Carotta, Gabrielle T. Belz   +11 more
doaj   +1 more source

PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation

BMC Immunology, 2021
Background Phosphoinositide-3-kinase-delta (PI3Kδ) inhibition is a promising therapeutic approach for inflammatory conditions due to its role in leucocyte proliferation, migration and activation.
Sorif Uddin, Augustin Amour, David J. Lewis, Chris D. Edwards, Matthew G. Williamson, Simon Hall, Lisa A. Lione, Edith M. Hessel   +7 more
doaj   +1 more source