Results 41 to 50 of about 128,560 (293)

Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cells

Life Science Alliance, 2022
Single-cell RNA sequencing of porcine ileal lymphocytes reveals similarities to human cells and discovery of porcine intestinal innate lymphoid cells. Lymphocytes can heavily influence intestinal health, but resolving intestinal lymphocyte function is ...
Jayne E Wiarda, Julian M Trachsel, Sathesh K Sivasankaran, Christopher K Tuggle, Crystal L Loving   +4 more
doaj   +1 more source

Innate immunity against HIV: a priority target for HIV prevention research. [PDF]

, 2010
This review summarizes recent advances and current gaps in understanding of innate immunity to human immunodeficiency virus (HIV) infection, and identifies key scientific priorities to enable application of this knowledge to the development of novel ...
PAXTON W, ROMARIS M, LINDBLAD E, DONCEL G, BORROW P, Persephone Borrow, Borrow, P, LEHNER T, DE MAGISTRIS MT, Shattock, Robin J., MEDAGLINI, DONATA, Vyakarnam, Annapurna, PATTERSON S, Annapurna Vyakarnam, POLI G, EUROPRISE WORKING GROUP BOGERS W, KIRCHHOFF F, KELLY C, TOWERS G, SILVESTRI G, DEBRE P, Robin J Shattock, Shattock, RJ, SHATTOCK RJ, Vyakarnam Annapurna, Borrow, Persephone, Borrow Persephone, GOODIER M, null null, SPECK R, EUROPRISE Working Group, GEIJTENBEEK T, Vyakarnam, A, Shattock Robin J, WAGNER H., VYAKARNAM A   +35 more
core   +1 more source

Organoids capture tissue-specific innate lymphoid cell development in mice and humans

, 2022
Organoid-based models of murine and human innate lymphoid cell precursor (ILCP) maturation are presented. First, murine intestinal and pulmonary organoids are harnessed to demonstrate that the epithelial niche is sufficient to drive tissue-specific ...
Trieu, Tung-Jui, Graham M. Lord, Michael A. Curtis, Niazi, Umar, Lord, Graham, Gentleman, Eileen, Read, Emily, Joana F. Neves, Marta Vilà González, Rita Reis, Neves, Joana F., Tomasz Zabinski, Roberts, Luke; id_orcid, Davide Danovi, Luke B. Roberts, Curtis, Michael A., Danovi, Davide, Lord, Graham M., Jowett, Geraldine M, Vilà González, Marta, Emily Read, Umar Niazi, Roberts, Luke B., Eileen Gentleman, Coman, Diana, Zabinski, Tomas, Jowett, Geraldine M., Diana Coman, Reis, Rita, Geraldine M. Jowett, Ludovic Vallier, Vallier, Ludovic, Tung-Jui Trieu, Zabinski, Tomasz, Neves, Joana F   +34 more
core   +1 more source

Epigenomic Views of Innate Lymphoid Cells [PDF]

Frontiers in Immunology, 2017
The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise. The parallelism between ILCs and T cells extends beyond these two cell types and comprises other innate-like T lymphocytes ...
Sciume G, Shih HY, Mikami Y, O'Shea J.J.
openaire   +3 more sources

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality [PDF]

, 2016
Innate lymphoid cells (ILCs) play key roles in host defense, barrier integrity, and homeostasis and mirror adaptive CD4(+) T helper (Th) cell subtypes in both usage of effector molecules and transcription factors.
Mikami, Yohei, Sun, Hong-Wei, Davis, Fred P., Shih, Han-Yu, O'Shea, John J., Sciumè, Giuseppe, Kanno, Yuka, Guo, Liying, Brooks, Stephen R., Urban, Joseph F.   +9 more
core   +1 more source

Innate Lymphoid Cells in Intestinal Inflammation [PDF]

Frontiers in Immunology, 2017
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn's disease (CD) and ulcerative colitis. The cause of IBD is unknown, but the evidence suggests that an aberrant immune response toward the commensal bacterial flora is responsible for disease in genetically susceptible individuals.
Geremia, A, Arancibia-Cárcamo, C
openaire   +4 more sources

Innate lymphoid cells [PDF]

Current Opinion in Organ Transplantation, 2015
The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation.Innate lymphoid cells encompass several novel cell types whose wide-ranging roles in the ...
David R, Withers, Emma C, Mackley, Nick D, Jones   +2 more
openaire   +2 more sources

Tissue-specific transcriptional profiles and heterogeneity of natural killer cells and group 1 innate lymphoid cells

, 2022
International audienceNatural killer (NK) cells and type 1 innate lymphoid cells (ILC1s) are populations of non-T, non-B lymphocytes in peripheral tissues.
Vivier, Eric, Kerdiles, Yann M., Galluso, Justine, Escalière, Bertrand, Carpentier, Sabrina, Kerdiles, Yann, Lopes, Noella   +6 more
core   +1 more source

Innate Lymphoid Cells [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2013
Innate lymphoid cells (ILCs) represent a novel family of developmentally related hematopoietic effectors with central roles in innate immune responses to infections, lymphoid organogenesis, intestinal homeostasis, and wound healing.1 The prototypes of the ILC family are natural killer cells and lymphoid tissue–inducer cells.
Alain, Tedgui, Hafid, Ait-Oufella
openaire   +2 more sources

Innate Lymphoid Cells in Crohn’s Disease [PDF]

Frontiers in Immunology, 2020
Innate lymphoid cells (ILCs) are a large family of cells of the immune system that performs various functions in immune defense, inflammation, and tissue remodeling. As a part of the innate immune system, ILCs are a distinct form of lymphocytes different from T and B cells.
Ying Wu, Jun Shen
openaire   +3 more sources