Results 51 to 60 of about 128,560 (293)

The divergence between T cell and innate lymphoid cell fates controlled by E and Id proteins

Frontiers in Immunology, 2022
T cells develop in the thymus from lymphoid primed multipotent progenitors or common lymphoid progenitors into αβ and γδ subsets. The basic helix-loop-helix transcription factors, E proteins, play pivotal roles at multiple stages from T cell commitment ...
Aneta Pankow, Aneta Pankow, Xiao-Hong Sun, Xiao-Hong Sun, Xiao-Hong Sun   +4 more
doaj   +1 more source

Tissue localization of natural killer cells dictates surveillance of lung metastasis

Nature Communications
The lung is a common metastatic site for various cancer types. Successful immune surveillance of lung metastasis depends on Natural Killer (NK) cells, but the underlying mechanisms are elusive.
Marijne Vermeer, Colin Sparano, Nicolò Coianiz, Maud Mayoux, Gioana Litscher, André Fonseca, Stanislav Dergun, Caroline Mussak, Lukas Rindlisbacher, Philipp Häne, Laura Ducimetière, Tobias Wertheimer, Burkhard Becher, Lothar C. Dieterich, Sònia Tugues   +14 more
doaj   +1 more source

The transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15Rα chain

Frontiers in Immunology
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells ...
Sergio Forcelloni, Julien Giron-Michel, Piero Del Boccio, Piero Del Boccio, Maria Concetta Cufaro, Maria Concetta Cufaro, Alice Di Sebastiano, Alice Di Sebastiano, Francesca Romana Mariotti, Cecilia Ciancaglini, Salem Chouaib, Salem Chouaib, Mael Padelli, Mael Padelli, Simone Vespa, Giang Dang Mac, Stefan Ebert, Stéphanie Buart, Enrico Maggi, Lorenzo Moretta, Paola Vacca, Nicola Tumino, Linda Quatrini, Ignazio Caruana, Bruno Azzarone, Silvia Santopolo   +25 more
doaj   +1 more source

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

, 2017
Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity.
Bruchard, Melanie, Bianca Blom, Spits, Hergen,, Melanie Bruchard, Anne S. Cornelissen, Mebius, Reina E.,, Mjösberg, Jenny, Erjefält, Jonas S., Ros, Xavier Romero,, Shikhagaie, Medya Mara,, Cornelissen, Anne S.,, Jenny Mjösberg, Mori, Michiko,, Björklund, Åsa K., Cornelissen, Anne S, Bal, Suzanne M, Shikhagaie, Medya Mara, Björklund, Åsa K, Spits, Hergen, Medya Mara Shikhagaie, Mebius, Reina E, Koning, Jasper J.,, Ros, Xavier Romero, Michiko Mori, Jasper J. Koning, Xavier Romero Ros, Blom, Bianca,, Reina E. Mebius, Åsa K. Björklund, Mori, Michiko, Bruchard, Melanie,, Cornelissen, Anne S., Mjösberg, Jenny,, Björklund, Åsa K.,, Koning, Jasper J, Erjefält, Jonas S, Bal, Suzanne M., Erjefält, Jonas S.,, Jonas S. Erjefält, Hergen Spits, Bal, Suzanne M.,, Koning, Jasper J., Lund University., Mebius, Reina E., Blom, Bianca, Suzanne M. Bal   +45 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Group 2 innate lymphoid cells are key in lipid transfer protein allergy pathogenesis

Frontiers in Immunology
BackgroundImmunopathology in food allergy is characterized by an uncontrolled type 2 immune response and specific-IgE production. Recent studies have determined that group 2 innate lymphoid cells (ILC2) participate in the food allergy pathogenic ...
Francisca Palomares, Natalia Pérez-Sánchez, Natalia Pérez-Sánchez, Nazaret Nieto, Rafael Núñez, José Antonio Cañas, María del Carmen Martín-Astorga, María del Carmen Martín-Astorga, Anyith Cruz-Amaya, María José Torres, María José Torres, María José Torres, Ibon Eguíluz-Gracia, Ibon Eguíluz-Gracia, Cristobalina Mayorga, Cristobalina Mayorga, Francisca Gómez, Francisca Gómez   +17 more
doaj   +1 more source

Transcriptional regulators dictate innate lymphoid cell fates

Protein & Cell, 2017
Research on innate lymphoid cells (ILC) has recently been a fast paced topic of immunological research. As ILCs are able to produce signature Th cytokine, ILCs have garnered considerable attention and have been described to represent the innate ...
Chao Zhong, Jinfang Zhu
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metabolic Control of Innate Lymphoid Cell Migration

Frontiers in Immunology, 2019
Innate lymphoid cells (ILCs) are specialized immune cells that rapidly respond to environmental challenges, such as infection and tissue damage. ILCs play an important role in organ homeostasis, tissue repair, and host defense in the mucosal tissues ...
Tim Willinger
doaj   +1 more source

Modulation by luminal factors on the functions and migration of intestinal innate immunity

Frontiers in Immunology, 2023
Luminal antigens, nutrients, metabolites from commensal bacteria, bile acids, or neuropeptides influence the function and trafficking of immune cells in the intestine.
Masaaki Higashiyama, Soichiro Miura, Ryota Hokari   +2 more
doaj   +1 more source