Results 61 to 70 of about 128,560 (293)

Innate Lymphoid Cell Relations

, 2010
A common progenitor cell gives rise to distinct lineages of innate lymphoid cells in the gastrointestinal tract.
David R. Withers, Veldhoen, M, Withers, David, Marc Veldhoen   +3 more
core   +1 more source

Metabolic features of innate lymphoid cells

Journal of Experimental Medicine, 2022
Innate and adaptive immune cells are found in distinct tissue niches where they orchestrate immune responses. This requires intrinsic and temporal metabolic adaptability to coordinately activate the immune response cascade. Dysregulation of this program is a key feature of immunosuppression.
Huiyang Yu, Nicolas Jacquelot, Gabrielle T. Belz   +2 more
openaire   +5 more sources

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

The development of innate lymphoid cells

Nature Immunology
Innate lymphoid cells (ILCs) are a diverse group of immune cells that possess many effector functions of T cells but lack somatically generated receptors. They have crucial roles in early immune responses and in maintaining tissue integrity. We review ILC developmental pathways and progenitors in mice, with a particular focus on adult bone marrow but ...
Arundhoti Das, Yi Ding, Christelle Harly, Avinash Bhandoola   +3 more
openaire   +3 more sources

Innate Lymphoid Cells in the Skin [PDF]

Journal of Investigative Dermatology, 2015
Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions.
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Lymphedema in patients with X-linked severe combined immunodeficiency

Journal of Allergy and Clinical Immunology: Global
Background: IL2RG and JAK3 mutations cause T-cell–negative, B-cell–positive, natural killer cell–negative severe combined immunodeficiency (SCID). Cell therapies such as hematopoietic stem cell transplantation (or gene therapy for IL2RG deficiency) can ...
Filippo Consonni, MD, Suk See De Ravin, MD, PhD, Stephane Vignes, MD, Virginie Courteille, PhD, Marina Cavazzana, MD, PhD, Laureline Berteloot, MD, PhD, Alain Fischer, MD, PhD, Bénédicte Neven, MD, PhD   +7 more
doaj   +1 more source

Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence

, 2016
Group 3 innate lymphoid cells (ILC3) are major regulators of inflammation and infection at mucosal barriers1. ILC3 development is thought to be programmed1, but how ILC3 perceive, integrate and respond to local environmental signals remains unclear. Here
Luís Almeida, García Cassani, Bethania, Bethania García-Cassani, Tânia Carvalho, Misic, Ana M., Bartow McKenney, Casey, Ribeiro, Hélder, Eberl, Gérard, Veiga Fernandes, Henrique, Marques, Rute, Denise M. Larson, Gérard Eberl, Rute Marques, Henrique Veiga-Fernandes, Larson, Denise M., Pavan, William J., Carvalho, Tânia, Sales Ibiza, Hélder Ribeiro, Casey Bartow-McKenney, William J. Pavan, Ibiza Martinez, Sales, Almeida, Luís, Grice, Elizabeth A., Ana M. Misic, Elizabeth A. Grice   +25 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Type 1 Innate Lymphoid Cells Limit the Antitumoral Immune Response [PDF]

, 2021
International audienceNatural killer (NK) cells are known to be able to kill established tumor cell lines, but important caveats remain regarding their roles in the detection and elimination of developing primary tumors.
Justine Galluso, Vienne, Margaux, Sophie Guia, Escalière, Bertrand, Etiennot, Marion, Spinelli, Lionel, Fenis, Aurore, Lionel Spinelli, Eric Vivier, Kerdiles, Yann, M, Guia, Sophie, Bertrand Escalière, Marion Etiennot, Vivier, Eric, Galluso, Justine, Margaux Vienne, Aurore Fenis, Yann M. Kerdiles   +17 more
core   +1 more source