Results 11 to 20 of about 130,824 (258)
Innate lymphoid cells in neuroinflammation
Frontiers in Cellular NeuroscienceInnate lymphoid cells (ILCs) are largely tissue-resident cells that participate in the maintenance of tissue homeostasis and react early to inflammatory events.
Daria Kveštak +4 more
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Epigenomic Views of Innate Lymphoid Cells [PDF]
Frontiers in Immunology, 2017 The discovery of innate lymphoid cells (ILCs) with selective production of cytokines typically attributed to subsets of T helper cells forces immunologists to reassess the mechanisms by which selective effector functions arise.
Giuseppe Sciumè +3 more
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Innate Lymphoid Cells in Intestinal Inflammation [PDF]
Frontiers in Immunology, 2017 Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine that encompasses Crohn’s disease (CD) and ulcerative colitis.
Alessandra Geremia +1 more
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The development of innate lymphoid cells. [PDF]
Nat ImmunolInnate lymphoid cells (ILCs) are a diverse group of immune cells that possess many effector functions of T cells but lack somatically generated receptors. They have crucial roles in early immune responses and in maintaining tissue integrity. We review ILC developmental pathways and progenitors in mice, with a particular focus on adult bone marrow but ...
Das A, Ding Y, Harly C, Bhandoola A.
europepmc +5 more sources
Human innate lymphoid cells [PDF]
Journal of Allergy and Clinical Immunology, 2016 Innate lymphoid cells (ILCs) are increasingly acknowledged as important mediators of immune homeostasis and pathology. ILCs act as early orchestrators of immunity, responding to epithelium-derived signals by expressing an array of cytokines and cell-surface receptors, which shape subsequent immune responses.
Jenny Mjösberg, Hergen Spits
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Innate Lymphoid Cell Immunometabolism [PDF]
Journal of Molecular Biology, 2017 Innate lymphoid cells (ILCs) are tissue-resident "first responders" of the immune system that function to protect epithelial barriers against pathogens and maintain tissue homeostasis. However, because ILCs are finely tuned to perturbations within tissue microenvironments, they can also contribute to host pathology when upstream activating signals are ...
Timothy E, O'Sullivan, Joseph C, Sun
openaire +2 more sources
Innate lymphoid cells and the skin [PDF]
BMC Dermatology, 2014 Innate lymphoid cells are an emerging family of effector cells that contribute to lymphoid organogenesis, metabolism, tissue remodelling and protection against infections. They maintain homeostatic immunity at barrier surfaces such as lung, skin and gut (Nature 464:1367-1371, 2010, Nat Rev Immunol 13: 145-149, 2013).
Salimi, Maryam, Ogg, Graham
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The evolution of innate lymphoid cells [PDF]
Nature Immunology, 2016 Innate lymphoid cells (ILCs) are the most recently discovered group of immune cells. Understanding their biology poses many challenges. We discuss here the current knowledge on the appearance of ILC subsets during evolution and propose how the connection between ILCs and T cells contributes to the robustness of immunity and hence to the fitness of the ...
Vivier, Eric +3 more
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Innate lymphoid cell memory [PDF]
Cellular & Molecular Immunology, 2019 Innate lymphoid cells (ILCs), including natural killer (NK) cells, ILC1s, ILC2s, ILC3s, and lymphoid tissue inducer (LTi) cells, comprise the first line of innate immune defense against pathogens and tumors. Over the past decade, accumulating evidence has demonstrated immunological memory in ILC subsets: for example, NK cells recall haptens, viruses ...
Xianwei, Wang, Hui, Peng, Zhigang, Tian
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Innate lymphoid cells and cancer
Nature Immunology, 2022 The innate lymphoid cell (ILC) family is composed of natural killer (NK) cells, ILC1, ILC2 and ILC3, which participate in immune responses to virus, bacteria, parasites and transformed cells. ILC1, ILC2 and ILC3 subsets are mostly tissue-resident, and are profoundly imprinted by their organ of residence.
Jacquelot, Nicolas +3 more
openaire +5 more sources