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Medecine sciences : M/S, 2017 Innate Lymphoid Cells (ILC) are tissue-resident effector lymphocytes that differ from the B and T lymphocytes subsets since they lack specific antigen receptors derived from gene rearrangements. They can be divided into two groups, cytotoxic ILC (NK cells) which are dependent on the transcription factors Eomes and T-bet and produce IFN-γ, and helper ...
Crinier, Adeline +3 more
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SnapShot: Innate Lymphoid Cells
Immunity, 2013 ILC1 α4β7+ α4β7SnapShot: Innate Lymphoid Cells Gregory F. Sonnenberg,1,3 Jenny Mjosberg,4 Hergen Spits,5 and David Artis2,3 1Departments of Medicine and 2Microbiology, 3Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA 4Karolinska University Hospital Huddinge, Karolinska Institutet, Sweden 5Tytgat Institute for Liver ...
Sonnenberg, Gregory F. +3 more
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HiJAKing Innate Lymphoid Cells? [PDF]
Frontiers in Immunology, 2017 The family of innate lymphoid cells (ILCs) consists of a heterogeneous group of cytokine-producing cells that have features in common with adaptive T helper (Th) cells. Cytokines acting through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathways are key players in both Th and ILC biology.
SCIUME', GIUSEPPE +2 more
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Innate lymphoid cells in the airways [PDF]
European Journal of Immunology, 2012 The airways, similar to other mucosal surfaces, are continuously exposed to the outside environment and a barrage of antigens, allergens, and microorganisms. Of critical importance therefore is the ability to mount rapid and effective immune responses to control commensal and pathogenic microbes, while simultaneously limiting the extent of these ...
Jennifer A, Walker, Andrew, McKenzie
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Current Opinion in Organ Transplantation, 2015 The purpose of this article is to review recent advances in our understanding of innate lymphoid cell function and to speculate on how these cells may become activated and influence the immune response to allogeneic tissues and cells following transplantation.Innate lymphoid cells encompass several novel cell types whose wide-ranging roles in the ...
David R, Withers +2 more
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Innate Lymphoid Cells in the Skin [PDF]
Journal of Investigative Dermatology, 2015 Innate lymphoid cells (ILCs) are part of a heterogeneous family of innate immune cells with newly identified roles in mediating immunity, tissue homeostasis, and pathologic inflammation. Here, we review recent studies delineating the roles of ILCs in the pathogenesis of multiple inflammatory skin disorders and their unique effector functions.
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Shaping Innate Lymphoid Cell Diversity [PDF]
Frontiers in Immunology, 2017 Innate lymphoid cells (ILCs) are a key cell type that are enriched at mucosal surfaces and within tissues. Our understanding of these cells is growing rapidly. Paradoxically, these cells play a role in maintaining tissue integrity but they also function as key drivers of allergy and inflammation.
Qiutong Huang +5 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2013 Innate lymphoid cells (ILCs) represent a novel family of developmentally related hematopoietic effectors with central roles in innate immune responses to infections, lymphoid organogenesis, intestinal homeostasis, and wound healing.1 The prototypes of the ILC family are natural killer cells and lymphoid tissue–inducer cells.
Alain, Tedgui, Hafid, Ait-Oufella
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Tissue localization of natural killer cells dictates surveillance of lung metastasis
Nature CommunicationsThe lung is a common metastatic site for various cancer types. Successful immune surveillance of lung metastasis depends on Natural Killer (NK) cells, but the underlying mechanisms are elusive.
Marijne Vermeer +14 more
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The Role of TOX in the Development of Innate Lymphoid Cells
Mediators of Inflammation, 2015 TOX, an evolutionarily conserved member of the HMG-box family of proteins, is essential for the development of various cells of both the innate and adaptive immune system.
Corey R. Seehus, Jonathan Kaye
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